Cell Therapy Research and Development Resources

Gain expert insight on cell therapy strategic approaches, best practices and critical considerations to advance your next breakthrough treatment from discovery to the clinic in this curated, on-demand collection.

Infographic

Challenges and Solutions in CAR-T Discovery and Development

Download this infographic to learn how CAR-T therapy works, the CAR-T therapy discovery and development steps and more

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characterization and optimization of induced pluripotent stem cell culture using advanced flow cytometry and live-cell analysis

Application Note

Selecting Optimal iPSCs Using a Combined Workflow

Understand methods for the characterization, maintenance, scale up, and selection of ideal iPSCs in a combined workflow approach

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Application Guides

Application Guide

Fully Automated Image-Based Single Cell and Colony Picking

Stem cells play an important role in the field of regenerative medicine for a wide range of biomedical and pharmaceutical research applications

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Application Guide

Label-free to Decipher CRISPR/Cas Mechanisms

Octet^® BLI to measure and characterize CRISPR/Cas mediated binding and Gene activation

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Application Notes

Application Note

Optimization of Human iPSC-derived Neuronal Mono- and Co-cultures with...

Learn how to maintain iPSC-derived neuronal & microglial models and a method for non-invasive, continuous monitoring of culture health.

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CGI representing advanced cell models, DNA, organoids

Application Note

iPSC Cultures with High Quality Growth Factors & Cytokines

Discover a simplified and robust method for differentiating iPSCs into hepatic organoids using Sartorius RUO Growth Factors and Cytokines.

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Application Note

Quantifying Organoid Growth with Live-cell Analysis and RUO Growth Fac...

Gain in-depth insights into the impact of growth factors and cytokines on organoid development, alongside real-time data analysis using the Incucyte^®...

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Induced Pluripotent Stem Cells iPSC Cell Therapy

Application Note

Optimizing iPSC Culture Protocol with Growth Factors & Cytokines

Effectively use growth factors & cytokines with iPSC media to preserve pluripotency, support growth & increase time between feedings.

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Application Note

Protein Domain Mapping Chemokines & SARS-CoV-2 Nucleocapsid

This application note discusses and characterizes of the interaction between the SARS-CoV-2 Nucleocapsid (N) protein and human chemokines.

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Application Note

Optimization of SH-SY5Y Differentiation Using Growth Factors and Cytok...

Translational In Vitro Models for Studying Human Development & Disease

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Application Note

Solutions for Culturing, Maintaining and Characterizing iPSCs

Learn about an accelerated and streamlined workflow approach for the culture, monitoring and characterization of iPSCs.

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Application Note

Selecting Optimal iPSCs Using a Combined Workflow

Understand methods for the characterization, maintenance, scale up, and selection of ideal iPSCs in a combined workflow approach

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utilizing advanced flow cytometry and live-cell imaging to evaluate iPSC pluripotency During Cell Line Selection

Application Note

iPSC Pluripotency During Cell Line Selection and Differentiation

Combined iQue^® 3 and Incucyte^® live-cell analysis workflow approach for evaluating iPSC pluripotency and differentiation.

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Benchmarking of Two Mycolplasma Real-time PCR Kits suitable for Release Testing According EP 2.6.7

Application Note

Benchmarking of the Microsart^® AMP Mycoplasma Kit

This application note presents a benchmark study comparing the capabilities of two different qPCR kits for the detection of Mycoplasma.

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Application Note

Combining Live-Cell Analysis and High-Throughput Flow Cytometry

To Gain Additional Insights into the Mechanisms of Immune Cell Killing of Tumor Cells

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Quantitative Live-Cell Analysis for Optimization of Culture Conditions and Evaluation of Cell Health

Application Note

Quantitative Live-Cell Analysis for iPSC Optimization

Quantitative live-cell analysis for optimization of culture conditions and evaluation of cell health in human iPSC-derived neurons.

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AI-Drivien Label-Free Quantification of Cell Viability Using Live-Cell Analysis

Application Note

AI-Driven Label-Free Quantification of Cell Viability

Using Live Cell Analysis

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Application Note

Best Pipetting Practices for Incucyte^® Lentivirus Titer Assay

Pipetting practices can greatly affect the reproducibility of sample prep or the outcome of cell assays. Learn best practices here.

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Application Note

Lab-Scale Harvest and Clarification of Lentiviral Vectors

Sartolab^®️ RF50, Sartoclear Dynamics^®️ Lab V50, and other manufacturers’ filters were evaluated for clarification of lentiviral vectors.

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Application Note

Real-Time Live-Cell Analysis of Lentiviral Titer Determination

Learn a real-time, image-based method to quantify the infectious titer of anti-CD19 CAR lentiviral vectors using the Incucyte^® Live-Cell Analysis Syst...

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Application Note

Quantifying T Cell Response in 3D Tumor Spheroids

Two Advanced Flow Cytometry Platform-based solutions to address problems with traditional methods of measuring T cell response in 3D models.

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Application Note

Centrifuge Free Clarification and Harvest of Adeno-associated Viruses

Learn how Sartoclear Dynamics^® Lab filtration is a viable approach to clarifying AAV crude cell lysates.

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Application Note

An Optimized, Multiplexed Assay for Screening Ex Vivo Conditions which...

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Articles

Article

Unlocking the Potential of CAR-T Therapies for Solid Tumors

The recent FDA approval of the very first CAR-T therapy marks a significant milestone in the field of cell and gene therapy

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Blogs

Cell Analysis

Apr 19, 2023 | 5 min read

The Transformative Power of Advanced Flow Cytometry in Cell and Gene Therapy

Cell and gene therapy is one of the most promising areas of biomedical research. In this post, we will focus on the role of advanced flow cytometry in CAR-T cell development.

Measure critical quality attributes blog illustration

Cell Analysis

Mar 09, 2023 | 10 min read

Therapeutics Development: Keeping Critical Quality Attribute (CQA) Analysis Simple and Data-rich

Learn about the importance of CQAs, the challenge of selecting the right ones and how the right equipment can simplify the process.

Cell Analysis

Aug 16, 2022 | 3 min read

How to Go from Cell Image to Insight, with Multivariate Analysis

Biologists spend huge amounts of time studying cells under the microscope. But how can we derive quantitative insights from complex cell morphology data?

Cell Analysis

Mar 07, 2022 | 10 min read

Plotting the Next Move in Immuno-Oncology

Cancers have a way of outmaneuvering I-O therapies. To win, scientists are using data-rich tools to understand the complex relationship between cancer and immune cells.

Cell Line Development

Mar 07, 2023 | 10 min read

Finding the Holy Grail of Cell Line Development: Viable, Monoclonal Cells

When it comes to laborious manual protocols, single-cell isolation is a top contender. Learn how one automated single-cell selection and retrieval platform is changing the game.

Cell Line Development

Jan 27, 2023 | 10 min read

Why Automation is Outpacing Traditional Methods for Single-Cell Cloning

While fluorescence-activated cell sorting (FACS) and limiting dilution have traditionally been used for single cell cloning, many are turning to automated, image-based solutions.

Cell Culture Media

Dec 09, 2022 | 5 min read

Culturing Mesenchymal Stem Cells for Therapeutic Grade Exosomes

Mesenchymal stem cells secrete tiny extracellular vesicles with big potential for therapeutic applications but choosing the right media to support their production is essential.

Brochures

Brochure

Lentiviral Vector Lab-Scale Production, From Research to the Clinic

Discover innovative solutions for both upstream and downstream workflows for lentivirus production.

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Brochure

Innovative Solutions for Next-Generation Cell Therapies

Simplify lab-scale cell therapy R&D workflows with our full ensemble of state-of-the-art solutions

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Brochure

Research Use Only (RUO) Growth Factors & Cytokines

Discover more about our range of high-quality, animal-derived component-free RUO Growth Factors & Cytokines

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eBooks

eBook

Lentiviral Vector Applications eBook

This eBook features chapters on upstream production, downstream processes, quality control assays and analytics for lentiviral vectors.

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eBook

CAR-T Therapies for Solid Tumors

Gaining Critical Characterization Insights for Development of CAR-T Therapies for Solid Tumors

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eBook

iQue^® 3 Next-Gen CAR-T Development App Compendium

Discover how cytometry enables you to expedite CAR-T discovery.

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eBook

Harnessing the Power of T Cells

This eBook focuses on the use of advanced flow cytometry and live-cell analysis in CAR-T development

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eBook

A Guide to High-Quality Laboratory Water

This Sartorius eBook is an informative guide for choosing the right water purification system for your laboratory.

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Flyers

Flyer

Rapid Sterility Solutions: Microsart^® ATMP Sterile Release

PDF | 932.6 KB

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Flyer

Rapid Solutions: Microsart^®️ ATMP Bacteria, Fungi and Mycoplasma

PDF | 759.1 KB | June 16, 2023

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Flyer

Rapid Mycoplasma Detection: Microsart^®️ AMP Extraction and Microsart^®️ ATMP Mycoplasma

PDF | 815.3 KB

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Infographics

Infographic

Top Tips for Success in iPSC-Derived Cell Therapy Development

Learn key tips for effectively and efficiently developing novel cell therapies with a maximized chance of clinical success.

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Infographic

How to Prevent Mycoplasma Contamination in Cell Cultures

Learn five tips for preventing mycoplasma contamination in the cell cultures in this easy-to-understand infographic.

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Infographic

Challenges and Solutions in CAR-T Discovery and Development

Download this infographic to learn how CAR-T therapy works, the CAR-T therapy discovery and development steps and more

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Infographic

Cell-Based Therapies: Be on the Safe Side

Ensure the highest patient safety with real-time PCR-based rapid sterility testing. Learn more in this infographic.

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Posters

Poster

96-Well Live-Cell Assays for Immune Cell Killing of 3D Tumour Spheroid...

Here we describe image-based, immune cell-killing assays of 3D tumour spheroids, geared for assessing the efficacy of novel immune-modulators.

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Poster

Impact of Pipetting Errors on Reproducibility of Cell-Based Assays

Download the scientific poster to learn more about how to reduce the variance with best sample preparation practices to provide more reliable and repr...

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Poster

Rapid, High Capacity Monitoring of T-Cell Activation for Adoptive Cell...

This study highlights the power of the iQue^® Screener PLUS platform to rapidly characterize multiple endpoints and the ForeCyt^® Software to...

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Poster

Screening Ex Vivo Conditions that Increase Memory T Cell Frequency

Using High Throughput Flow Cytometry and an Optimized Multiplexed Assay

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First Final Release Test of ATMPs Prior to Treatment Validation of a qPCR-Based Rapid Sterility Test

Poster

Rapid Sterility Testing for Cell Therapy Quality Control Poster

In this poster, a validation study was designed to evaluate bacterial and fungal detection capability.

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Webinars

Webinar

Webinar: Retaining Cell Viability and Morphology in iPSCs

Learn how to monitor, maintain and culture stem cells consistently and reliably while retaining high levels of cell health in this webinar.

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Webinar

Ensuring Regulatory Compliance in Cell Therapies from Lab to Bedside

This webinar explores Sartorius solutions for cell therapy workflows, focusing on 21 CFR Part 11 software for compliance simplification.

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Standalone filtration of cell culture with Sartolab RF 500

Webinar

Robust and Swift: Efficient One-Step Clarification Methods for AAV &am...

Watch this on-demand webinar to explore how body feed filtration can improve your clarification processes.

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Webinar

Enhancing Survival: Novel Methods for Stem Cell Colony Selection and R...

Human induced pluripotent stem cells (hiPSCs) are an invaluable resource in the field of regenerative medicine, with hiPSC reprogramming providing a p...

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Webinar

Disrupting the Solid Tumor Environment Using CAR T Therapies

In this webinar, Prasad Adusumilli, Stephen Gottschalk, and Leonid Metelitsa discuss the challenges of targeting CAR T and related ACT platforms to th...

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Webinar

Gene-Modulation Technologies in the Development of Cell-Based Therapie...

An overview of gene-modulation technologies and functional genomic screens

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Webinar

CAR T-Cell Therapy and Bispecific Antibodies

For a closer look at the design, development, and success of CAR T-cell therapy and bispecific antibodies, a panel of experts come together to discuss...

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