Cell Therapy Research and Development Resources

Gain expert insight on cell therapy strategic approaches, best practices and critical considerations to advance your next breakthrough treatment from discovery to the clinic in this curated, on-demand collection.

Featured Cell Therapy Resources

Compendium

Incucyte® Live-cell Analysis Applications: 3D Cell Culture Compendium

Download the Incucyte® 3D Cell Culture Compendium to explore real-time, label-free analysis of spheroids and organoids in live-cell research.

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Infographic

Challenges and Solutions in CAR-T Discovery and Development

Learn how new technologies are helping to overcome challenges in the discovery and development of CAR-T cell therapies.

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characterization and optimization of induced pluripotent stem cell culture using advanced flow cytometry and live-cell analysis
Application Note

Selecting Optimal iPSCs Using a Combined Workflow

Understand methods for the characterization, maintenance, scale up, and selection of ideal iPSCs in a combined workflow approach

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Application guides

Fully automated image-based single cell and colony picking for stem cells
Application Guide

Fully Automated Image-Based Single Cell and Colony Picking

Stem cells play an important role in the field of regenerative medicine for a wide range of biomedical and pharmaceutical research applications

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application guide thumbnail
Application Guide

Label-free to Decipher CRISPR/Cas Mechanisms

Octet® BLI to measure and characterize CRISPR/Cas mediated binding and Gene activation

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Application Notes

Application Note

Overcome the Challenges of Cerebral Organoid Research

Learn how to quantify iPSC-derived cerebral organoids using live-cell analysis and HTS. Download the full application note for details.

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Application Note

Quantify Cerebral Organoid Differentiation

Discover a workflow to monitor iPSC-derived brain organoids in real time using live-cell imaging and HTS for more reproducible, reliable research.

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A Comparative Study of the Effects of Media and Cytokines on Growth and Anti-Cancer Efficacy
Application Note

Optimizing T Cell Expansion and Anti-Cancer Efficacy

This study investigates the expansion of T cells by comparing the growth and anti-cancer effects of serum-free and serum-containing media.

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Neuron Cell Stock Image
Application Note

Optimization of Human iPSC-derived Neuronal Mono- and Co-cultures

Learn how to maintain iPSC-derived neuronal & microglial models and a method for non-invasive, continuous monitoring of culture health.

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Utilizing High-Quality Growth Factors and Cytokines in the Development of iPSC-Derived Hepatic Organoids
Application Note

iPSC Cultures with High Quality Growth Factors & Cytokines

Discover a simplified and robust method for differentiating iPSCs into hepatic organoids using Sartorius RUO Growth Factors and Cytokines.

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Organoids colored in pink, yellow, blue
Application Note

Quantifying Organoid Growth with Live-cell Analysis and RUO Growth Fac...

Gain in-depth insights into the impact of growth factors and cytokines on organoid development, alongside real-time data analysis using the Incucyte®...

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Induced Pluripotent Stem Cells iPSC Cell Therapy
Application Note

Optimizing iPSC Culture Protocol with Growth Factors & Cytokines

Effectively use growth factors & cytokines with iPSC media to preserve pluripotency, support growth & increase time between feedings.

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Application Note

Protein Domain Mapping Chemokines & SARS-CoV-2 Nucleocapsid

This application note discusses and characterizes of the interaction between the SARS-CoV-2 Nucleocapsid (N) protein and human chemokines.

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Application Note

Optimization of SH-SY5Y Differentiation Using Growth Factors and Cytok...

Translational In Vitro Models for Studying Human Development & Disease

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Solutions for Culturing, Maintaining and Characterizing iPSCs
Application Note

Solutions for Culturing, Maintaining and Characterizing iPSCs

Learn about an accelerated and streamlined workflow approach for the culture, monitoring and characterization of iPSCs.

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characterization and optimization of induced pluripotent stem cell culture using advanced flow cytometry and live-cell analysis
Application Note

Selecting Optimal iPSCs Using a Combined Workflow

Understand methods for the characterization, maintenance, scale up, and selection of ideal iPSCs in a combined workflow approach

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utilizing advanced flow cytometry and live-cell imaging to evaluate iPSC pluripotency During Cell Line Selection
Application Note

iPSC Pluripotency During Cell Line Selection and Differentiation

Combined iQue® 3 and Incucyte® live-cell analysis workflow approach for evaluating iPSC pluripotency and differentiation.

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Benchmarking of Two Mycolplasma Real-time PCR Kits suitable for Release Testing According EP 2.6.7
Application Note

Benchmarking of the Microsart® AMP Mycoplasma Kit

This application note presents a benchmark study comparing the capabilities of two different qPCR kits for the detection of Mycoplasma.

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cytokine app note
Application Note

Combining Live-Cell Analysis and High-Throughput Flow Cytometry

To Gain Additional Insights into the Mechanisms of Immune Cell Killing of Tumor Cells

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Quantitative Live-Cell Analysis for Optimization of Culture Conditions and Evaluation of Cell Health
Application Note

Quantitative Live-Cell Analysis for iPSC Optimization

Quantitative live-cell analysis for optimization of culture conditions and evaluation of cell health in human iPSC-derived neurons.

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AI-Drivien Label-Free Quantification of Cell Viability Using Live-Cell Analysis
Application Note

AI-Driven Label-Free Quantification of Cell Viability

Using Live Cell Analysis

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Application Note

Best Pipetting Practices for Incucyte® Lentivirus Titer Assay

Pipetting practices can greatly affect the reproducibility of sample prep or the outcome of cell assays. Learn best practices here.

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Application Note

Lab-Scale Harvest and Clarification of Lentiviral Vectors

Sartolab®️ RF50, Sartoclear Dynamics®️ Lab V50, and other manufacturers’ filters were evaluated for clarification of lentiviral vectors.

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Label-Free, Real-Time Live-Cell Analysis of Lentiviral Titer Determination
Application Note

Real-Time Live-Cell Analysis of Lentiviral Titer Determination

Learn a real-time, image-based method to quantify the infectious titer of anti-CD19 CAR lentiviral vectors using the Incucyte® Live-Cell Analysis Syst...

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Quantifying T Cell Response in 3D Tumor Spheroids Using Advanced Flow Cytometry Workflows
Application Note

Quantifying T Cell Response in 3D Tumor Spheroids

Two High-Throughput Screening by Cytometry solutions to address problems with traditional methods for measuring T cell response in 3D models

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Centrifuge Free Clarification and Harvest of Adeno-associated Viruses
Application Note

Centrifuge Free Clarification and Harvest of Adeno-associated Viruses

Learn how Sartoclear Dynamics® Lab filtration is a viable approach to clarifying AAV crude cell lysates.

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An Optimized, Multiplexed Assay for Screening Ex Vivo Conditions which Increase Memory T Cell Frequency
Application Note

An Optimized, Multiplexed Assay for Screening Ex Vivo Conditions which...

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Articles

Article

Unlock the Secrets of AAV Quantification Across Multiple Serotypes

Discover faster, high-throughput methods to quantify AAV serotypes with greater accuracy and less hands-on time.

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Article

Finding the Perfect Recipe for Cell Culture

Optimize cell culture protocols with high-quality reagents and supplements to craft the perfect recipe for reliable results and happy cells.

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Article

Advanced Screening Solutions for Efficient CAR-T Development Workflows

Learn how BLI is used in the characterization and analysis of antibodies and their fragments in the development of CAR constructs.

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Unlocking the Potential of CAR-T Therapies for Solid Tumors
Article

Unlocking the Potential of CAR-T Therapies for Solid Tumors

Learn about the progress researchers are making in developing off-the-shelf immunotherapies for the treatment of solid tumor malignancies.

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Blogs

Cell Analysis
Apr 19, 2023 | 5 min read

The Transformative Power of Advanced Flow Cytometry in Cell and Gene Therapy

Cell and gene therapy is one of the most promising areas of biomedical research. In this post, we will focus on the role of advanced flow cytometry in CAR-T cell development.

Measure critical quality attributes blog illustration
Cell Analysis
Mar 09, 2023 | 10 min read

Therapeutics Development: Keeping Critical Quality Attribute (CQA) Analysis Simple and Data-rich

Learn about the importance of CQAs, the challenge of selecting the right ones and how the right equipment can simplify the process.

Cell Analysis
Aug 16, 2022 | 3 min read

How to Go from Cell Image to Insight, with Multivariate Analysis

Biologists spend huge amounts of time studying cells under the microscope. But how can we derive quantitative insights from complex cell morphology data?

Cell Analysis
Mar 07, 2022 | 10 min read

Plotting the Next Move in Immuno-Oncology

Cancers have a way of outmaneuvering I-O therapies. To win, scientists are using data-rich tools to understand the complex relationship between cancer and immune cells.

cell line development honeycomb well
Cell Line Development
Mar 07, 2023 | 10 min read

Finding the Holy Grail of Cell Line Development: Viable, Monoclonal Cells

When it comes to laborious manual protocols, single-cell isolation is a top contender. Learn how one automated single-cell selection and retrieval platform is changing the game.

Cell Line Development
Jan 27, 2023 | 10 min read

Why Automation is Outpacing Traditional Methods for Single-Cell Cloning

While fluorescence-activated cell sorting (FACS) and limiting dilution have traditionally been used for single cell cloning, many are turning to automated, image-based solutions.

Cell Culture Media
Dec 09, 2022 | 5 min read

Culturing Mesenchymal Stem Cells for Therapeutic Grade Exosomes

Mesenchymal stem cells secrete tiny extracellular vesicles with big potential for therapeutic applications but choosing the right media to support their production is essential.

Brochures

Brochure

Lentiviral Vector Lab-Scale Production, From Research to the Clinic

Discover innovative solutions for both upstream and downstream workflows for lentivirus production.

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Brochure

Innovative Solutions for Next-Generation Cell Therapies

Simplify lab-scale cell therapy R&D workflows with our full ensemble of state-of-the-art solutions

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Brochure

Research Use Only (RUO) Growth Factors & Cytokines

Discover more about our range of high-quality, animal-derived component-free RUO Growth Factors & Cytokines

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eBooks

eBook

Exploring the Versatility of Using 3D Spheroid Models in Research

Discover how 3D spheroid models and live-cell analysis enhance drug discovery, model relevance, and data quality in this expert-led eBook.

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eBook

Advancing Pipetting Techniques for 3DCell Culture Innovation

Optimize pipetting techniques to enhance reproducibility, avoid contamination, and accelerate scientific progress in 3D cell cultures.

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Mesenchymal stem cell SEM stock image - pink cell on brown background
eBook

The Promise of Regeneration

MSCs and Exosomes in Modern Medicine.

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eBook

The Future of 3D Cell Analysis: From Isolation to Insight eBook

Learn methods to enhance the reproducibility, efficiency, and physiological relevance of 3D cell models and accelerate R&D breakthroughs.

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Induced Pluripotent Stem Cells iPSC Cell Therapy
eBook

Mastering Cell Cultures with Superior Media & Live-Cell Insights

Learn the importance of meticulous cell culture practices and how top-tier media and technology can drive advancements in R&D.

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CGI showing disease modeling using organoids
eBook

The Progress and Promise of iPSCs in Disease Modeling

Learn best practices for using iPSCs in disease modeling as well as tips and solutions for streamlined R&D workflows for advanced cell models.

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eBook

Lentiviral Vector Applications eBook

This eBook features chapters on upstream production, downstream processes, quality control assays and analytics for lentiviral vectors.

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eBook

CAR-T Therapies for Solid Tumors

Gaining Critical Characterization Insights for Development of CAR-T Therapies for Solid Tumors

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eBook

iQue® 3 Next-Gen CAR-T Development App Compendium

Discover how cytometry enables you to expedite CAR-T discovery.

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eBook

Harnessing the Power of T Cells

This eBook focuses on the use of advanced flow cytometry and live-cell analysis in CAR-T development

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A guide to high quality laboratory water ebook cover
eBook

A Guide to High-Quality Laboratory Water

This Sartorius eBook is an informative guide for choosing the right water purification system for your laboratory.

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Rapid Sterility Solutions: Microsart®️ ATMP Sterile Release
Flyer

Rapid Sterility Solutions: Microsart® ATMP Sterile Release

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Rapid Solutions: Microsart®️ ATMP Bacteria, Fungi and Mycoplasma flyer cover
Flyer

Rapid Solutions: Microsart®️ ATMP Bacteria, Fungi and Mycoplasma 

PDF | 759.1 KB
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Rapid Mycoplasma Detection: Microsart®️ AMP Extraction and Microsart®️ ATMP Mycoplasma
Flyer

Rapid Mycoplasma Detection: Microsart®️ AMP Extraction and Microsart®️ ATMP Mycoplasma

PDF | 815.3 KB
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Infographics

DNA vs. mRNA Transfection Infographic Preview
Infographic

DNA vs. mRNA Transfection: Pros, Cons, and Tips

DNA and mRNA transfection introduce genetic material into cells differently. Learn about each method, pros and cons of each, and top tips.

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Infographic

The Critical Role of Growth Factors and Cytokines in Advancing R&D

Discover the transformative role of growth factors and cytokines in biomedical research in this free infographic.

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Induced Pluripotent Stem Cells iPSC Cell Therapy
Infographic

Top Tips for Success in iPSC-Derived Cell Therapy Development

Learn key tips for effectively and efficiently developing novel cell therapies with a maximized chance of clinical success.

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How to Prevent Mycoplasma Contamination in Cell Cultures infographic preview
Infographic

How to Prevent Mycoplasma Contamination in Cell Cultures

Learn five tips for preventing mycoplasma contamination in the cell cultures in this easy-to-understand infographic.

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Infographic

Challenges and Solutions in CAR-T Discovery and Development

Learn how new technologies are helping to overcome challenges in the discovery and development of CAR-T cell therapies.

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cell based therapies: be on the safe side
Infographic

Cell-Based Therapies: Be on the Safe Side

Ensure the highest patient safety with real-time PCR-based rapid sterility testing. Learn more in this infographic.

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Posters

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Poster

Integrated 3D Multi-Organ Plate for Real-Time Drug Toxicity Analysis

Explore a new 3D multi-organ tox plate with real-time analysis for faster, scalable, and animal-free drug toxicity testing.

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preview of poster
Poster

In vitro reconstructed model of human epidermis for studying skin pigm...

Discover a 3D human epidermis model with melanocytes for studying pigmentation, phototype differences, and skin-lightening efficacy.

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Poster

Steric exclusion chromatography for purifying lentiviral vectors

Learn an optimized purification protocol for achieving LV particle recovery of 86% and infectious recovery of 88%.

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Poster

Enhancing Human T-cell mRNA Transfection

This study uses live-cell analysis and high-throughput screening to optimize T-cell transfection for proliferation and function.

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Poster

Automating Robust and Reproducible 3D Culture Model Systems

Explore a simple, standardized, and robust workflow to identify, select, monitor, and assess 3D cell models for further development.

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Scientific Poster
Poster

96-Well Live-Cell Assays for Immune Cell Killing of 3D Tumour Spheroid...

Here we describe image-based, immune cell-killing assays of 3D tumour spheroids, geared for assessing the efficacy of novel immune-modulators.

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Impact of Pipetting Errors on Reproducibility of Cell-Based Assays
Poster

Impact of Pipetting Errors on Reproducibility of Cell-Based Assays

Download the scientific poster to learn more about how to reduce the variance with best sample preparation practices to provide more reliable and repr...

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Rapid, High Capacity Monitoring of T-Cell Activation for Adoptive Cell Therapy
Poster

Rapid, High Capacity Monitoring of T-Cell Activation for Adoptive Cell...

This study highlights the power of the iQue® Screener PLUS platform to rapidly characterize multiple endpoints and the ForeCyt® Software to...

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Screening Ex Vivo Conditions that Increase Memory T Cell Frequency
Poster

Screening Ex Vivo Conditions that Increase Memory T Cell Frequency

Using High Throughput Flow Cytometry and an Optimized Multiplexed Assay

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First Final Release Test of ATMPs Prior to Treatment Validation of a qPCR-Based Rapid Sterility Test
Poster

Rapid Sterility Testing for Cell Therapy Quality Control Poster

In this poster, a validation study was designed to evaluate bacterial and fungal detection capability.

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Technical Notes

Technical Note

Efficient Transfection of Lymphocytes with mRNA Using jetMESSENGER®

This study demonstrates the transfection efficiency of jetMESSENGER® for delivering mRNA into T lymphocytes, B lymphocytes, and NK cells.

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Webinars

Webinar

Advanced Strategies for Effective mRNA Transfection in T Cells

On-demand webinar: Learn advanced mRNA transfection strategies to optimize T cell engineering for cell therapy development.

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Webinar

Mastering Cell Cultures

Tailored media and supplements can assist scale-up for industrial applications and better mimic in vivo conditions for translational R&D.

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Floating Pink Spheroids on a dark background
Webinar

3D Culture Workflows: Automating the Generation of Clonal Spheroids&nb...

Discover a robust and automated workflow for the generation of monoclonal iPSC spheroid structures from a single cell.

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Red pheroid organoids floating together in space.
Webinar

From iPSCs to Organoids: Streamlining Hepatic Differentiation

Discover a simple, standardized, and robust workflow to generate functional hepatic cells and organoids from iPSCs. 

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Webinar

Optimizing CAR-T Characterization with a Streamlined Workflow

Gain dynamic insights into CAR-T cell behavior, learn tools for characterization, and methods for optimizing expansion conditions.

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Induced Pluripotent Stem Cells iPSC Cell Therapy
Webinar

Webinar: Retaining Cell Viability and Morphology in iPSCs

Learn how to monitor, maintain and culture stem cells consistently and reliably while retaining high levels of cell health in this webinar.

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woman in hospital with IV bag
Webinar

Ensuring Regulatory Compliance in Cell Therapies from Lab to Bedside

This webinar explores Sartorius solutions for cell therapy workflows, focusing on 21 CFR Part 11 software for compliance simplification.

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Standalone filtration of cell culture with Sartolab RF 500
Webinar

Robust and Swift: Efficient One-Step Clarification Methods for AAV &am...

Watch this on-demand webinar to explore how body feed filtration can improve your clarification processes.

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Webinar

Enhancing Survival: Novel Methods for Stem Cell Colony Selection and R...

Human induced pluripotent stem cells (hiPSCs) are an invaluable resource in the field of regenerative medicine, with hiPSC reprogramming providing a p...

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Webinar

Disrupting the Solid Tumor Environment Using CAR T Therapies

Experts discuss the challenges of targeting CAR T and related ACT platforms to the solid tumor environment and strategies for disruption.

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Webinar

Gene-Modulation Technologies in the Development of Cell-Based Therapie...

An overview of gene-modulation technologies and functional genomic screens

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Webinar

CAR T-Cell Therapy and Bispecific Antibodies

For a closer look at the design, development, and success of CAR T-cell therapy and bispecific antibodies, a panel of experts come together to discuss...

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Webinar

Organoids, iPSCs, and Advanced Cell Models

Understand the importance of advanced cell models for development of novel treatments and personalized medicine in this expert panel webinar.

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Webinar

T Cell Characterization Combining Advanced Flow Cytometry with Live Ce...

This webinar provides an overview of advanced cell analysis techniques and details how to combine them, for maximum insight into T cell biology.

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Webinar

Reduce Cycle Times for AAV Quantification

See the Octet® AAVX Biosensor in comparison to an in-house assay on the Octet BLI platform.

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White Papers

White Paper

Live-Cell Monitoring: Optimizing Workflows for Advanced Cell Models

Explore how real-time live-cell analysis allows scientists to optimize every phase of their assay development—from culture to manipulation to readout.

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CGI showing disease modeling using organoids
White Paper

Pluripotent Stem Cells, the Building Blocks of Organoids

Read about PSCs, their role in developing organoids, and the many emerging and exciting applications for organoids.

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White Paper

Optimized Aliquoting for Robust CGT Processes

Learn about challenges with liquid handling in cell and gene therapy processes and novel solutions that simplify aliquoting.

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White Paper

Continuous Live-Cell Analysis of the Immune-Tumor Axis

Driving Biological Insight and Productivity With Real-Time Non-Invasive Phenotypic Assays

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Phenotypic and Functional Characterization of CAR-T Cells white paper
White Paper

Phenotypic and Functional Characterization of CAR-T Cells

Learn about streamlined in vitro assays used for phenotyping and functional assessment of modified CAR-T cells, with three case studies.

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White Paper

Streamlining Affinity Analysis for Accelerated Lead Screening

Antibody and other protein therapeutics are a major focus in drug discovery pipelines today. 

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Live Cell Analysis for Neuroscientists
White Paper

Live-Cell Analysis for Neuroscientists

Neurobiology applications using live-cell analysis for studies in both human induced pluripotent stem cells (iPSCs) and primary cell models.

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Explore Sartorius

Cell Therapy CAR-T cell attacking cancer cell

Discovery, Development, and Manufacturing of Cell Therapies

Cell-based therapies provide new opportunities to treat disease and offer hope to patients in need.

Explore Cell Therapy