Resource overview:
Traditional toxicity screening methods are limited in scope and speed—especially when it comes to capturing complex organ interactions. In this scientific poster, explore how a newly developed Multi-Organ Tox Plate (MOTP) paired with automated live-cell imaging and analysis is redefining how researchers approach in vitro toxicity testing.
What you’ll learn:
- How 3D tissue models representing the intestine, liver, and kidney are integrated into a 96-well plate format
- How real-time toxicity measurements are captured using Cytotox Green Dye and Incucyte® live-cell analysis
- Insights from dose-response experiments using Cisplatin, Fialuridine, and Troglitazone
- Automated EC₅₀ calculations that streamline your workflow
- Why this approach is a scalable, cost-effective alternative to animal models
Key results include:
- Drug-specific organ toxicity trends validated across multiple tissues
- Real-time barrier integrity monitoring via TEER measurements
- High-throughput, reproducible toxicity assessments with reduced manual intervention
