eBook: Upstream, Downstream & Analytics for Lentiviral Vector Applications
Last updated: June 2023
Overview
Lentiviral vectors (LVs) are typically derived from HIV and are able to infect both dividing and non-dividing cells, making them useful tools to deliver therapeutic genes to treat genetic disorders or diseases. LVs have been used in numerous cell and gene therapy clinical trials and six therapies based on LVs have been approved by the FDA to date.
Overall, LV production is a complex and challenging process that requires a careful balance between virus yield, purity, and safety. The state of the art continues to evolve, with new technologies and methods being developed to improve the efficiency and safety of LV-based cell and gene therapies.
This eBook features chapters on upstream production, downstream processes, quality control assays and analytics.
- Document type: eBook
- Page count: 22
- Read time: 30 minutes
Key Takeaways:
- Benefits of continuous live-cell analysis in immunology
- Utilizing more precise instruments that meet strict compliance regulations to study ligand binding
- Quantifying antibody-dependent cellular phagocytosis using advanced flow cytometry
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Lentiviral Vector Applications eBook
