Process Chromatography Solutions

Chromatography is the workhorse of downstream bioprocesses, but capture chromatography is one of the most expensive and rate-limiting steps. Low flow rates extend the processing time and limit the productivity of downstream production. Non-value-added activities – such as column packing and system cleaning – also strain resources and increase risk, operational area, and footprint.   

These chromatography challenges create broad opportunities for improving efficiency during downstream processes. It is time for the industry to collectively re-imagine chromatography to overcome these obstacles.

Imagine Being Ahead of the Curve 
Re-Imagine Chromatography

The industry is on the cusp of a paradigm shift in chromatography. By embracing more effective technologies and adopting process intensification strategies, you can pioneer these innovations and establish next-generation, streamlined purification processes.

Explore our range of systems specifically designed for intensification and chromatography media to start building an efficient downstream process tailored to your needs.

Start Your Downstream Intensification Journey

Downstream process intensification increases productivity and flexibility while decreasing COGs and timelines. Yet, knowing how to integrate strategies into your process can pose a challenge. 
Whether you want to boost the productivity of your capture step or intensify your entire downstream process. Find a system suitable for your purification needs.

Explore Our Sartobind® Membrane Toolbox

Explore Resolute® BioSMB

Explore Resolute® BioSC 

Achieve Robust Purification of Large Biomolecules

Next-generation therapies typically rely on large particles such as nucleic acids, viral particles, and exosomes.  These biomolecules challenge conventional chromatography techniques, which struggle to quickly yield high recoveries while also maintaining the required purity.

Adapt to the challenges of evolving therapeutics with next-generation solutions designed for the purification of large biomolecules.

Explore CIM® Monolithic Columns

Sartobind® Membrane Toolbox

Purify With Sartobind®

Are you ready to re-imagine your chromatography workflow? Membranes have an open structure that supports faster flow rates, accelerating process timelines and lowering the cost of goods.

Sartobind® Rapid A has several benefits compared to Protein A resins:

  • Up to 14x more productivity at capture using rapid cycling
  • No column-packing required, freeing up resources
  • Lifetime utilization is achieved in one batch, minimizing storage requirements

Our broader Sartobind® Membrane toolbox covers the entire workflow and offers up to 30x productivity gain during polishing in flowthrough mode.

Learn MoreRequest a Demo | Quote 

Resolute® BioSMB

Intensify with Resolute® BioSMB

Are you ready to re-imagine your chromatography workflow? Multi-column chromatography supports better resin utilization, meaning considerable savings, especially at the affinity capture step.

Intensify your capture chromatography with the Resolute® BioSMB multi-column chromatography system:

  • Up to 80% reduction in resin volumes and costs
  • Up to 5x increase in productivity
  • Reduced buffer consumption

Learn More Request a Demo | Quote 

Resolute® BioSC

Intensify with Resolute® BioSC

Are you ready to re-imagine your entire downstream process? Our multi-step chromatography solutions support the connected and continuous operation of multiple steps on a single system.

Intensify your downstream workflow with the Resolute® BioSC multi-step chromatography system.

  • Up to 3x reduction in footprint
  • Reduced CAPEX
  • Up to 40% reduction in batch time
  • Modular concept means you can configure the system to fit your process needs

Learn MoreRequest a Demo | Quote

CIM® Monoliths

Purify Nucleic Acids or Viral Vectors With Monoliths

Are you ready to re-imagine large biomolecule purification? Our chromatography monoliths are ideal for the purification of molecules commonly used in next-generation therapies (such as mRNA and viral particles).

Enhance the purification of your new modalities with CIM® monolithic chromatography.

  • High-resolution capabilities in combination with low shear flow properties for quality yields
  • Increased productivity thanks to improved yields and faster run times
  • Available in plug-and-play formats across a large range of chemistries and scales

Learn MoreRequest a Demo | Quote

Explore Our Wider Chromatography Portfolio

Learn More About Process Chromatography

White Paper

Re-Imagining Chromatography

Learn how to build efficient, connected downstream processes with our white paper.

Download Now

Webinar | Intensifying mAbs Processing for Robust Manufacturing

Connecting & intensifying your mAbs processing can improve productivity. See an example in action in this ondemand webinar.

Watch Webinar

Webinar | Imagine Seamless Scale up to Rapid Cycling

Learn how chromatography membranes offer advantages over protein A resins.

Learn More

Related Blog Articles

Mar 08, 2023 | 4 min read

Considerations for Transitioning to Multi-Column Chromatography

MCC can help you improve efficiency while achieving your desired QTPP. Learn what to consider when transitioning from single to multi-column chromatography.

Mar 29, 2023 | 4 min read

Cost-Effectivity Due to Improved Productivity in mAb Capture

It’s time to be practical about productivity in chromatography. Find out how to make your mAb capture more productive, and the additional benefits of switching from resins to membranes.

Jan 13, 2023 | 4 min read

Accelerate Scale-Up with Sartobind® Rapid A

Demand for higher output and flexible manufacturing of mAbs requires new solutions. Membrane chromatography offers several key advantages over columns for highly productive and scalable processes.

Related Assets

White Paper

Re-Imagining Chromatography - Building Efficient, Connected Downstream Processes

PDF | 2.4 MB

Implementing Chromatographic Methods for Evaluating Large-Scale Monolithic Columns for AAV Capsid Separation

PDF | 531.9 KB
Application Note

Integrated | Connected Downstream Processing of mAbs With Resolute® BioSC for Improved Productivity, Cost, Footprint, and Facility Utilization

PDF | 524.3 KB

Comparability Study of an Ion Exchange Monolith and Affinity Resin for the Purification of AAV8

PDF | 2.7 MB
Application Note

A New Way to Perform mAb Capture: Scaling Rapid Cycling Membrane Chromatography From Bench to Commercial Manufacturing

PDF | 492.4 KB
Application Note

Intensifying a mAb Polishing Platform — Targeting Time, Cost, and Space Efficiency

PDF | 972.3 KB
Success Story

How DISCOVER® Surveys Optimize End-to-End Processes to Reduce Costs and Improve Yields

PDF | 292.1 KB

Poster: Proof of Concept for MAbs Purification: From Batch to Intensified and Connected Process

PDF | 643.9 KB

Accelerate Downstream Processes With Membrane-Based mAb Purification 

PDF | 982.6 KB

Re-Imagining Chromatography - Navigating the Path to Downstream Intensification

PDF | 567.6 KB

Consult Our Experts

Consult Our Experts

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