Chromatography Membranes

Sartobind® Membrane Adsorbers – Trusted for More Than Two Decades in Commercial Processing

Sartobind® membranes transform chromatography steps into a highly productive process, from screening to production:

  • The high flow rates of these adsorptive membranes make them 150× faster than a traditional column
  • The capsule and cassette formats eliminate the need for packing hardware
  • The membrane can be sized to fit the impurity removal process based on capacity rather than flowrate
  • Single-use consumables eliminate the need for costly cleaning validation
  • Available in a variety of chemistries
Ease of use

Capsules can be handled like a filter, and cassettes can be installed in less than 10 minutes

Scalability

From 96-well plates to 5 L capsules and modular cassettes, Sartobind® offers a linear scale-up to all process scales

Speed

High flow rates (5 – 20 MV/min) reduce processing time, a dramatic contrast to columns  with 0.5 CV/min or slower flow rates

Footprint reduction

The capsule and cassette formats eliminate the need for column packing, reducing the required facility space

Lower COGS

Single-use consumables eliminate need for cleaning validation, while the fit based on capacity vs. flow rate reduces buffer consumption

Sartobind Membranes for All Process Scenarios

Sartobind® membranes are available for both flowthrough and bind/elute applications. 


Sartobind® Q

Sartobind STIC® PA

Sartobind® S

Sartobind® Phenyl

Ligand 

Quaternary ammonium 

Primary amine 

Sulfonic acid 

Phenyl 

Functionality

Strong AEX 

Salt-tolerant AEX 

Strong CEX 

Hydrophobic Interaction 

Bed height 

4 and 8 mm for flowthrough and Bind/Elute 

4 mm for Flowthrough only 

4 and 8 mm 

8 mm for bind/elute only 

Common uses 


Endotoxin/DNA/HCP removal 

Virus purification

Endotoxin/DNA/HCP/virus removal

HCP/Aggregate removal

Aggregate/HCP/virus/lipid/dye/endotoxin removal 

Nucleic acid purification

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Sartobind® IEX Membranes

High Speed IEX Capture/Polishing

Sartobind® IEX membranes enable rapid purification of various biomolecules.  Ready-to-use format minimizes set-up time and makes chromatography a simple and highly productive process step.


Sartobind® Q

Sartobind STIC® PA

Sartobind® S

Ligand

Quaternary ammonium

Primary amine

Sulfonic acid

IEX Type

Strong anion exchange

Salt-tolerant weak anion exchange

Strong cation exchange

Typical DBC at 10% breakthrough

BSA: 29 mg/mL

BSA: 50 mg/mL
DNA: 11 mg/mL

Lysozyme:25 mg/mL

pH stability

1-14

2-12

3-14

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Sartobind® Q

Sartobind® Q is highly flexible and used  in a wide variety of processes such as the removal of HCP, DNA, viruses, and endotoxins. It is also applied for virus and nucleic acid (DNA/RNA) purification.
As with all Sartobind® membranes, the large pore structure is particularly suited to large biomolecules.

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Sartobind STIC® PA

Sartobind STIC® PA can operate at high conductivity and can remove DNA at up to 1.5 M NaCl.  DNA removal is possible even in the presence of phosphate buffers, which offers some unique processing opportunities.

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Sartobind® S

Sartobind® S membrane adsorber is approved for use in drug manufacturing to remove host cell proteins at high flow rates. As a cation exchanger, Sartobind® S displays aggregate removal capabilities and typically achieves at least ten-fold higher binding capacity for viruses and virus-like-particles (VLP).

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Sartobind® Membranes in HIC

Sartobind® Phenyl – Easy Aggregate Removal

Sartobind® Phenyl is a hydrophobic interaction membrane with low ligand substitution. This allows for mild elution conditions for the purification of all biomolecules.

Sartobind® Phenyl membranes can be considered as a replacement to columns for polishing (flow-through) operations and a number of bind-and-elute applications, as they work at much higher flow rates, reduced complexity and without size exclusion effects when purifying large biomolecules.

The typical dynamic binding capacity (DBC) at 10 % breakthrough is:
•    9-13 mg/mL mAb
•    10 mg/mL BSA
•    23 mg/mL Lysozyme


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Affinity Membranes

Coming Soon: A Built-for-Purpose Membrane for Rapid Cycling Chromatography (RCC)

Rapid Cycling Chromatography in bioprocessing offers extremely high productivity compared to traditional and multi-column chromatography.

Implementing RCC requires the fine-tuned interaction of the appropriate devices, a supporting skid technology, and a purpose-designed membrane to provide high mass transfer combined with high permeability.

In addition to 10 to 15 times higher productivity, RCC allows process simplification, miniaturization and flexibility, bioburden risk mitigation and bound capital reduction.

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