Automated Chromatography Columns

Column preparation operations, particularly packing, are regarded as high risk clean room events. These risks include human error, packing failure, and absence of experienced operators; they can result in plant downtime, loss of product or separation media and inefficient use of resources. The Resolute AutoPak software was developed in direct response to this industry need for packing consistency by fully automated operations. 

Resolute Linear Columns

The Resolute Linear column range offers a unique combination of active multi-axis piston control, precision linear actuation and fully automated unit operations. This removes the need for a separate packing skid. 

  • Fully automated, reliable, time-efficient packing 

  • Reduced operator activity and human error 

  • Safe, clean, quiet operation 

  • Reduction of additional equipment and cleanroom size 

  • Configurable to suit a wide range of processes

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The Resolute Linear column range offers a unique combination of active multi-axis piston control, precision linear actuation and fully automated unit operations

  • Fully automated, reliable, time-efficient packing
  • Reduced operator activity and human error
  • Safe, clean, quiet operation
  • Reduction of additional equipment and cleanroom size
  • Configurable to suit a wide range of processes

Resolute Linear chromatography columns are designed for large scale pilot and production use. They are available from 350 mm to 2000 mm internal diameter (ID), in all common sizes. The columns utilize the proven Resolute wetted flowpath providing low pressure drop and high-resolution chromatography over a wide range of normal operating flow rates. The typical flow ranges from 30 to 800 cm/h.

Pack-in-place nozzles are used, with identical remote controlled three position nozzles at the top and bottom of the column. This technology allows packing and unpacking without opening the column. Resolute Linear columns include Resolute AutoPak software enabling fully automated packing, unpacking, and cleaning-in-place (CIP) of the column at the touch of a button. This removes the need for a packing skid.

The column valves and piston can also be controlled manually, meaning that traditional fixed or variable geometry pack in place methods can still be performed if required.

A range of material options and accessories is available to configure Resolute Linear columns to your requirements. A standard Resolute Linear column is configured with the Resolute AutoPak system, 20 μm polyethylene sinters, an acrylic tube, 3 barg operating pressure and 50 –550mm packed bed height capability.

The automated sequences enable total media usage and ‘re-pack in place’, saving valuable chromatography separation media and removing the need to store excess separation media when not packing the column. When using expensive separation media, this results in significant cost savings over other products that are not fully automated.

The Resolute AutoPak system was developed in direct response to an industry need for fully automated operations. Often key column preparation operations, particularly packing, are regarded as high risk clean room events. These risks include human error, packing failure, and absence of experienced operators; they can result in plant downtime, loss of product or sorbent and inefficient use of resources.

By adopting a fully automated approach, the Resolute AutoPak system greatly simplifies operation, effectively eliminates operator error and reduces the burden on key operators. The automated sequences assure that reproducible and consistent operation is the norm. Plus the ability to utilise all chromatography sorbent during packing results in cost savings and less financial variance.

Resolute® AutoPak - Fully automated column packing, unpacking and clean-in-place (CIP) at the touch of a button

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Resolute® Linear Chromatography Columns - Automated chromatography columns for pilot and process scale

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