Flexsafe® Pro Mixer Single-Use Mixer
Fast, Flexible, & Intelligent Single-Use Mixing From Lab to Large-Scale
When it comes to mixing operations in a bioprocessing environment, quality and efficiency are critical — and your choice of mixing equipment affects both. Choosing a fast and flexible single-use mixer gives you a competitive advantage by helping you maximize throughput and increase production.
We combined customer feedback with 20 years of single-use fluid management experience to design the Flexsafe® Pro Mixer.
New: Flexsafe® Pro Mixer 5 L | 10 L | 20 L
Flexsafe® Pro Mixer 5 L | 10 L | 20 L is a single-use benchtop mixer designed for small-scale mixing from 0.5 to 20 liters.
- Powerful and low-shear mixing to ensure quality
- Single-use mixing for regulatory compliance
- Versatility to support every step in your process
- Scalability to enable predictable performance
One Mixing Solution for All Mixing Steps in cGMP Bioprocessing
With the flexibility to accommodate both low-shear and rapid-mixing applications, Flexsafe® Pro Mixer brings single-use technology to a wide range of mixing steps in upstream and downstream processes.
- Reduces risk of operator error
- Supports in-line monitoring and control
- Protects shear-sensitive products
- Comes with fast installation and easy setup
From Small to Large-Scale Mixing
By using advanced, powerful, low-shear levitating technology, Flexsafe® Pro Mixer offers efficient and versatile mixing from 5 to 3000 liters. Its adaptable design ensures scalability, making it ideal for a wide range of mixing needs.
| Small Scale | Intermediate Scale | Large Scale | |
| Tank Volume | 5 to 20 L | 50 to 1000 L | 1500 to 3000 L |
| Mixing Volume Range | 0.5 to 23 L | 5 to 1050 L | 150 to 3050 L |
| Shape | Cubical shape Centered impeller | Cubical shape Centered impeller | Rectangular shape Off-centered impeller |
| Learn More | Learn More | Learn More |
Demonstrates high efficiency with buffers, media, aluminum gel, and viscous products
Optimizes product quality by combining a levitating impeller with limited shear work
Ensures consistent mixing from 5 to 1,000 liters, supporting seamless scale-up
Controls all critical mixing parameters essential for cGMP production
Installs within 5-10 minutes with easy-to-follow instructions
Flexsafe® Pro Mixer for Small Scale
Flexsafe® Pro Mixer 5 L | 10 L |20 L
Flexsafe® Pro Mixer is a single-use, benchtop mixer designed for small-scale mixing from 5 to 20 liters. It builds on advanced Pro Mixer technology and combines a high-torque motor with low-shear mixing capabilities.
It’s designed with the versatility needed to support all process stages and applications, including upstream, downstream, and final formulation.
Three Main Components
Flexsafe® Pro Mixer Bag - from 5 to 20 L
Built on 20 years of single-use fluid management experience, our predesigned solutions have supported process optimization across a variety of applications — from buffer and media preparation to downstream steps and final formulation.
With an ergonomic design, Flexsafe® Pro Mixer mixer offers rapid bag installation, expedites the mixing run, and enables bag handling throughout your process.
Predesigned single-use options provide simpler, safer, faster, and cheaper supply chain solutions.
Flexsafe® Pro Mixer Base Unit
The Base Unit incorporates a levitation mechanism to support contact-free mixing, and a compact design for easy installation. It offers versatile speed control and efficient line management.
Levitation and rotation mechanism for contact-free mixing
- Compact design fits easily on a bench or cart
- Adjustable speed range from 10 to 750 rpm for various process steps
- Includes tube holders for efficient line management
- Compatible with 5, 10, and 20 L Flexsafe® Pro Mixer Bag Holders
Flexsafe® Pro Mixer Bag Holders from 5 to 20 L
The Bag Holder is designed to be user-friendly while supporting intensive operations.
- Enables simple installation and easy access for filling, sampling, and draining with a specially designed front door
- Ensures maximum product recovery and avoids manual bag handling with a sloped bottom plate
- Supports visual monitoring throughout mixing by incorporating windows on the door and sides
Flexsafe® Pro Mixer for Intermediate and Large Scales
Flexsafe® Pro Mixer from 50 L to 3000 L
The Flexsafe® Pro Mixer is an advanced single-use mixer that supports a wide range of mixing steps in both upstream and downstream processes.
Three Main Components
Flexsafe® Pro Mixer Bag
Built on 20 years of single-use fluid management experience, our predesigned solutions have supported processes optimization across a variety of applications — from buffer and media preparation to downstream steps and final formulation.
With an ergonomic design, Flexsafe® Pro Mixer mixer offers rapid bag installation, expedites the mixing run, and enables bag handling throughout your process.
Predesigned single-use options provide simpler, safer, faster, and cheaper supply chain solutions.
Flexsafe® Pro Mixer Drive Unit
The Pro Mixer drive unit levitates and rotates the single-use magnetic impeller in the mixing bag with no surface contact. It’s flexible, mobile, cart-mounted, and designed to interface with all types and volumes of Palletank® for Mixing units.
The Pro Mixer drive unit enables automated control of mixing parameters, integrates a user-friendly touchscreen interface, and can manage multiple Palletank® for Mixing units.
Palletank® for Mixing
Palletank® for Mixing is a stainless-steel container designed for use with the Flexsafe® Pro Mixer bag and drive unit. The front doors make it easy to install the mixing bag, and the front port gate simplifies tubing line and sensor installation, as well as handling during filling, sampling, and draining.
With rapid setup with a pre-installed mixing bag, you can begin mixing operations in just a few minutes. Additionally, you can integrate volume and temperature control with options for weighing functions and heat exchange jackets.
Assurance of Single-Use System Integrity
Supplier Integrity Test
To provide integrity assurance for critical applications, we offer supplier integrity testing performed at our manufacturing sites. This is available for the complete bag and line assemblies for Flexsafe® Pro Mixer Bags up to 650 liters.
- Improves patient safety
- Supports regulatory compliance
Point-Of-Use Leak Test
For critical process steps, you can opt for a 100% point-of-use leak test to avoid the risk of losing your high-value product, and enhance patient and operator safety by ensuring that no damage occurred during shipping, storage, and handling of your single-use Flexsafe® Pro Mixer bags.
Learn More About Flexsafe® Pro Mixer
Flexsafe® Pro Mixer in Different Applications
Optimized media formulation can have a significant impact across upstream operations. The Flexsafe® Pro Mixer combines speed and efficiency to deliver high performance mixing during media powder dissolution.
Optimized buffer formulation can have a significant impact across downstream operations. The Flexsafe® Pro Mixer combines speed and efficiency to deliver high performance mixing, preparing solution from liquid buffer concentrates and dissolving buffer powders even in worse-case conditions such as high volume and high concentration, making the buffer preparation step quick and easy to perform.
Flexsafe® Pro Mixer technology allows low shear mixing to preserve the drug during viral inactivation. The single-use sensors are integrated for safe and reliable use across the process steps. Drain valves are available to avoid hold up volumes into the tubes.
Drug substance purification is a critical process step due to the risk of impurities being introduced either during the process or with the products used in biomanufacturing – but the integrity of the drug substance can also be at risk. The Flexsafe® Pro Mixer features a levitating impeller to preserve the drug substance during low shear blending applications and a design that supports taking off-line samples for other quality control tests prior to sterile filtration.
Blending of Viscous Solutions With the Flexsafe® Pro Mixer 5 L | 10 L | 20 L
PDF | 1.2 MB
Maximizing Scale and Speed with Intensified Single-Use Tangential Flow Filtration (SUTFF)
PDF | 1.1 MB
Preserving the drug product during the final formulation is critical, not just from a quality standpoint, but also to prevent the risk of significant waste. The Flexsafe® Pro Mixer, designed with its levitating impeller, ensures the integrity of the drug product during sterile and aseptic operations. Pre-designed Solutions (PDS) for either sterile or aseptic connections and disconnections, with options of single-use or integrated sensors, ensure safe and reliable use throughout the final formulation process.
