Preparative HPLC Chromatography Systems

From Process Development to Manufacturing

Changes in the pharmaceutical industry are driving new manufacturing requirements, meaning that facilities must provide for:

  • High temperature processes 
  • Complex molecules, multiple products and smaller batch sizes 
  • Flexible, easy to clean and compact equipment

From development to commercial phase, the Hipersep® platform  is a preparative HPLC system designed for the purification of peptides, oligonucleotides, insulin and other small molecules.

Hipersep® Platform

Find the Right Preparative HPLC System

The Hipersep® platform offers highly sophisticated, easy-to-use equipment with a unique, compact design controlled by the Hipersep® SC software.

  • Highly flexible configuration
  • Sanitary, easy-to-clean system
  • Compact and ergonomic design
  • Large flowrate range
  • Fully automated system


Hipersep® Pilot

Hipersep® Process M

Hipersep® L

Hipersep® XLHipersep® XXL

Scale

PD / Clinical

Clinical / Commercial Manufacturing

Clinical / Commercial Manufacturing

Commercial Manufacturing

Commercial Manufacturing

Flow Rate Range

6-90 L/hr

60-500 L/hr or
20-200 L/hr (Low Flow Version)

300-1000 L/hr

500-1600 L/hr

1000-2500 L/hr

Max Pressure

100 bars

100 bars

100 bars

100 bars

70 bars

Typical Column Diameter

50/80/110/150 mm

110/150/200/300/450 mm

450/590 mm

590/800 mm

800/1000 mm

Certification and Explosion proof

CE certification with optional ATEX Zone 2
UL certification with optional Class I Division 2

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Hipersep® Pilot

The Hipersep® Pilot is a modular, compact and ergonomic system designed to minimize cross-contamination risk.

  • Build in flexibility with over 1,000 possible configurations that integrate with columns from 50 to 150 mm ID
  • Minimize risk of cross contamination with a sanitary, easy-to-clean concept
  • Save facility space with a compact and ergonomic design

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Hipersep® Process M

This innovative system has a pressure capacity of up to 100 bars and is compatible with high-temperature purification processes (up to 85°C), allowing for unmatched performance levels while meeting the stringent challenges of new pharmaceutical applications such as oligonucleotides.

  • Guaranteed and repeatable performance
  • Scale-up flexibility
  • Fast and easy cleaning validation

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Varicol® Multi-Column and Continuous HPLC Chromatography

Varicol® is a multi-column continuous chromatography concept particularly well-suited to large-scale separation of binary mixtures (e.g., enantiomers) and fractionation of complex mixtures. This technology is designed to adapt seamlessly to users’ specific requirements.

  • A robust continuous process
  • Cost-effective and highly productive
  • Up to 99.97% of solvent recycled at commercial scale

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Learn More About HPLC Chromatography Systems

Featured Assets

Application Note

Hipersep® Pilot System and Cyclojet Process Enables Intensified HPLC

PDF 2.5 MB
Application Note

Successful Cannabinoid Purification and Scale-up on Hipersep® Pilot

PDF 3.2 MB

Related Assets

Brochure

Hipersep® Pilot

PDF | 1.2 MB
Brochure

Hipersep® Process M

PDF | 4.3 MB
Brochure

Hipersep® HPLC Chromatography Systems

PDF | 832.2 KB
Brochure

Prochrom® HPLC Chromatography Columns

PDF | 2.2 MB

Consult Our Experts

Consult Our Experts