High-Performance, High-Pressure Liquid Chromatography (HPLC) Systems
From Clinical to Commercial and Industrial HPLC Processes
The growing complexity and diversity of drug pipelines are driving new manufacturing requirements. These include:
- High-temperature processing for complex molecules like oligonucleotides
- Flexible and easy-to-clean equipment for multi-product facilities
- Compact equipment for small batch sizes
Preparative HPLC Systems Portfolio
Find the Right Preparative HPLC System
The Hipersep® Flowdrive Platform is a family of preparative HPLC systems designed for the purification of peptides, oligonucleotides, insulin, and other small molecules. It offers highly sophisticated, easy-to-use equipment with a unique, compact design controlled by the Hipersep® SC software.
| Hipersep® Flowdrive Pilot | Hipersep® Flowdrive Process M | Hipersep® Flowdrive Process L | Hipersep® Flowdrive XXL | |
|---|---|---|---|---|
| Scale | Clinical manufacturing | Clinical | commercial manufacturing | Clinical | commercial manufacturing | Commercial manufacturing |
| Flow Rate Range | 6-90 L/h | 60-500 L/h or 20-200 L/h (low-flow version) | 300-1,600 L/h | 1,000-2,500 L/h |
| Max Pressure | 100 bar | 100 bar | 100 bar | 70 bar |
| Typical Column Diameter | 5 | 80 | 110 |150 mm | 110 | 150 | 200 | 300 | 450 mm | 300 | 450 | 590 | 800 mm | 800 | 1000 mm |
| Sanitary Design* | No | Yes | Yes | No |
| Certification and Explosion Protection | CE certified, with optional ATEX Zone 2 compliance | |||
| ||||
Sanitary design*: To minimize risk of cross contamination, fittings have been used that eliminate retention volume, all the wetted surface has a surface finishing (Ra 0.5), and systems have low point drains to drain liquid in all parts.
Supporting Products & Services
Learn More About Preparative HPLC Systems
Highlight Asset
Broad Experience Supplying HPLC Systems
Sartorius has extensive experience supplying HPLC systems to the global market. We have significant installations in established modalities like antibody drug conjugates (ADC) and insulin, plus a very good installed base in the newer oligonucleotide and GLP-1 processes.
Our installed base numbers are greater than 1,500 units across systems and columns with many repeat customers, scaling from process development to large-scale commercial production.
Frequently Asked Questions
This is an additional system that boosts the inlet pressure to a main HPLC system. This ensures that the high-pressure pumps operate under optimum conditions to deliver the best gradient function possible. The booster pump module connects fluidically and electronically to the main skid to be controlled centrally from the HPLC system HMI.
The process versions of the Hipersep® range are capable of processing at higher temperatures, feature an improved sanitary design, and are available in a finer surface finish to better process oligonucleotides and other newer modalities.
Please contact your local sales representative for a competitive quote. We are in the process of finalizing the Hipersep Process XXL design in line with the rest of the range and can easily offer process upgrades. As a reminder, the process versions of the Hipersep® range can process at higher temperatures, feature an improved sanitary design, and are available in a finer surface finish to better process oligonucleotides and other newer modalities.
Typically, our systems can achieve a gradient accuracy of 1% of the set point in the pump optimal range, at lower flow rates the accuracy can be around 2%.
