Preparative HPLC Chromatography Systems
From Process Development to Manufacturing
Changes in the pharmaceutical industry are driving new manufacturing requirements, meaning that facilities must provide for:
- High temperature processes
- Complex molecules, multiple products and smaller batch sizes
- Flexible, easy to clean and compact equipment
From development to commercial phase, the Hipersep® platform is a preparative HPLC system designed for the purification of peptides, oligonucleotides, insulin and other small molecules.
Hipersep® Platform
Find the Right Preparative HPLC System
The Hipersep® platform offers highly sophisticated, easy-to-use equipment with a unique, compact design controlled by the Hipersep® SC software.
- Highly flexible configuration
- Sanitary, easy-to-clean system
- Compact and ergonomic design
- Large flowrate range
- Fully automated system
| Hipersep® Pilot | Hipersep® Process M | Hipersep® L | Hipersep® XL | Hipersep® XXL | |
|---|---|---|---|---|---|
Scale | PD / Clinical | Clinical / Commercial Manufacturing | Clinical / Commercial Manufacturing | Commercial Manufacturing | Commercial Manufacturing |
Flow Rate Range | 6-90 L/hr | 60-500 L/hr or | 300-1000 L/hr | 500-1600 L/hr | 1000-2500 L/hr |
Max Pressure | 100 bars | 100 bars | 100 bars | 100 bars | 70 bars |
Typical Column Diameter | 50/80/110/150 mm | 110/150/200/300/450 mm | 450/590 mm | 590/800 mm | 800/1000 mm |
Certification and Explosion proof | CE certification with optional ATEX Zone 2 | ||||
Hipersep® Pilot
The Hipersep® Pilot is a modular, compact and ergonomic system designed to minimize cross-contamination risk.
- Build in flexibility with over 1,000 possible configurations that integrate with columns from 50 to 150 mm ID
- Minimize risk of cross contamination with a sanitary, easy-to-clean concept
- Save facility space with a compact and ergonomic design
Hipersep® Process M
This innovative system has a pressure capacity of up to 100 bars and is compatible with high-temperature purification processes (up to 85°C), allowing for unmatched performance levels while meeting the stringent challenges of new pharmaceutical applications such as oligonucleotides.
- Guaranteed and repeatable performance
- Scale-up flexibility
- Fast and easy cleaning validation
Varicol® Multi-Column and Continuous HPLC Chromatography
Varicol® is a multi-column continuous chromatography concept particularly well-suited to large-scale separation of binary mixtures (e.g., enantiomers) and fractionation of complex mixtures. This technology is designed to adapt seamlessly to users’ specific requirements.
- A robust continuous process
- Cost-effective and highly productive
- Up to 99.97% of solvent recycled at commercial scale
