Preparative HPLC Chromatography Systems
From Process Development to Manufacturing
Changes in the pharmaceutical industry are driving new manufacturing requirements, meaning that facilities must provide for:
- High temperature processes
- Complex molecules, multiple products and smaller batch sizes
- Flexible, easy to clean and compact equipment
From development to commercial phase, the Hipersep® Flowdrive Platform is a preparative HPLC system designed for the purification of peptides, oligonucleotides, insulin and other small molecules.
Hipersep® Flowdrive Platform
Find the Right Preparative HPLC System
The Hipersep® Flowdrive Platform offers highly sophisticated, easy-to-use equipment with a unique, compact design controlled by the HiperSep® SC software.
- Highly flexible configuration
- Sanitary, easy-to-clean system
- Compact and ergonomic design
- Large flowrate range
- Fully automated system
| Hipersep® Flowdrive Pilot | Hipersep® Flowdrive Process M | Hipersep® Flowdrive L | Hipersep® Flowdrive XL | Hipersep® Flowdrive XXL | |
|---|---|---|---|---|---|
Scale | Process Development/ Clinical | Clinical / Commercial Manufacturing | Clinical / Commercial Manufacturing | Commercial Manufacturing | Commercial Manufacturing |
Flow Rate Range | 6-90 L/hr | 60-500 L/hr or | 300-1000 L/hr | 500-1600 L/hr | 1000-2500 L/hr |
Max Pressure | 100 bars | 100 bars | 100 bars | 100 bars | 70 bars |
Typical Column Diameter | 50/80/110/150 mm | 110/150/200/300/450 mm | 450/590 mm | 590/800 mm | 800/1000 mm |
Certification and Explosion proof | CE certification with optional ATEX Zone 2 | ||||
Hipersep® Flowdrive Pilot
The Hipersep® Flowdrive Pilot is a modular, compact and ergonomic system designed to minimize cross-contamination risk.
- Build in flexibility with over 1,000 possible configurations that integrate with columns from 50 to 150 mm ID
- Minimize risk of cross contamination with a sanitary, easy-to-clean concept
- Save facility space with a compact and ergonomic design
Hipersep® Flowdrive Process M
This innovative system has a pressure capacity of up to 100 bars and is compatible with high-temperature purification processes (up to 85°C), allowing for unmatched performance levels while meeting the stringent challenges of new pharmaceutical applications such as oligonucleotides.
- Guaranteed and repeatable performance
- Scale-up flexibility
- Fast and easy cleaning validation
Hipersep® Varicol Multi-Column and Continuous HPLC Chromatography
Hipersep® Varicol is a multi-column continuous chromatography concept particularly well-suited to large-scale separation of binary mixtures (e.g., enantiomers) and fractionation of complex mixtures. This technology is designed to adapt seamlessly to users’ specific requirements.
- A robust continuous process
- Cost-effective and highly productive
- Up to 99.97% of solvent recycled at commercial scale
