Plug. Play. Change the Game. Sartobind® Rapid A for mAb Capture

Sartobind® Rapid A: A Scalable, Disposable, Ready-To-Use mAb Capture Membrane

Replace Columns With A Scalable, Ready-To-Use & Disposable Alternative

Resin-based packed bed chromatography for mAb capture hampers downstream processing with low productivity, laborious cleaning requirements, and high costs. Sartobind® Rapid A is a game-changing, disposable "plug and play" alternative that uses a one-batch, one-membrane approach through rapid cycling. Its advantages over resin-based batch operations include:

  • 10x increased productivity
  • Reduced bioburden risk
  • Lower CoGs
  • Fully proven scalable solution from PD to commercial scale

Sartobind® Rapid A - Plug and Play mAb Capture 

Traditional mAb capture methods are inefficient and costly. Sartobind® Rapid A from Sartorius changes the game with a one-batch, one-membrane alternative that cuts time, risks, and costs associated with resin-based batch operations.

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Eliminate Costly Column Activities

No more column handling or risky consumable reuse — Sartobind® Rapid A removes the need for resin.

Cut Cost of Bulk Resin|Underutilization

Sartobind® Rapid A cuts costs using less chromatographic material per batch which will be fully utilized.

Accelerate Speed to Clinic

Rapid cycling and high binding capacity boost productivity 10x. Perform lifetime studies in one day.

Adopt a Fully Proven Scalable Solution

Scale up based on binding capacity with constant residence time, productivity, and operating pressures.

Cut Risk of Bioburden Linked to Columns

Using a new membrane for each batch eliminates the risk of bioburden.

Scale Up Faster With Zero Columns

Adopt a Fully Proven Scalable Solution From PD to Commercial Scale

Sartobind® Rapid A is the first portfolio to cover PD, clinical and commercial scales. A constant bed height over different device sizes allows easy scale-up based on binding capacity, preserving productivity, flow rates, and quality.

  • Scale up seamlessly
  • Simplify linear scalability with modular cassette format
  • Benefit from short cycle times, high productivity, and operating pressures <0.2 MPa

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Scale Up Easily With the Sartobind® Rapid A Portfolio

Sartobind® Rapid A is a fully proven scalable solution from PD to commercial scale. Devices include nano- and mini-sized solutions for benchtop systems, larger capsules for pilot testing, and modular cassettes for commercial manufacturing. The family of products eases the gradual expansion of rapid cycle chromatography across your operations.

  • Ligand: Protein A
  • Bed height: 4 mm


Attributes

Sartobind® Rapid A NanoSartobind® Rapid A Mini

Sartobind® Rapid A 75 mL

Sartobind® Rapid A 200 mL

Sartobind® Rapid A Cassette

Scale of Operation

Process Development

Process Development

Clinical Scale

Clinical Scale

Late Clinical to Commercial Scale

Membrane Volume

1.2 mL

10 mL

75 mL

200 mL

800 mL

Connector

Female luer

Female luer; sanitary ¾”, 25 mm

Sanitary ¾”, 25 mm

Sanitary 1 ½”, 50.5 mm

Via manifold accessory: sanitary 1 ½”, 50.5 mm

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Chromatography System Solutions Ideally Suited for Sartobind® Rapid A

Multi-Use Membrane Chromatography System: Resolute®️ MU RCC

Resolute®️ MU RCC is a dedicated membrane chromatography system that perfectly fits Sartobind®️ Rapid A 75 mL and 200 mL capsules.

Explore Resolute®️ RCC MU

Single-Use Batch Chromatography System: Resolute®️ Flowdrive SU

Resolute® Flowdrive SU with Sartobind® Rapid A supports single-use processes and fits 200 mL capsules and up to 3 cassettes.

Explore Resolute®️ Flowdrive SU

Save Time, Cut Costs and Reduce Risk With Sartobind® Rapid A

Rapid Cycling Yields Higher Productivity at Lower Cost With Less Risk

Sartobind® Rapid A’s one-batch, one-membrane approach minimizes bioburden risks, cuts unproductive activities, and saves on developing therapeutics by removing the high cost of bulk resin. Sartobind® Rapid A represents the next generation of mAb capture.

  • Cut 80% of non-productive column-use activities
  • Save up to 30% on process costs in clinical scale production
  • Minimize cross-contamination risk

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Traditional Batch vs. Rapid Cycling Chromatography

Break Through DSP Bottlenecks With Sartobind® Rapid A

Process intensification efforts on the upstream side have contributed to bottlenecks downstream. Typical batch approaches to mAb capture can lengthen process times. To break through this bottleneck in downstream processing, Sartorius developed a new technology. Rapid cycling chromatography with Sartobind® Rapid A improves productivity to accelerate speed to clinic.

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Rapid Cycling Chromatography

Rapid cycling chromatography purifies a batch over a large number of very short cycles. To make this possible, a new matrix was developed that allows comparable binding capacity at shorter residence time (higher flow rates).

  • One small device for mAb capture
  • One batch is purified over a large number of cycles
  • 10-15 minute cycles
  • Typical productivity of the mAb capture step: > 150 g/L*h
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Packed Bed Chromatography in Batch Approach

Packed bed chromatography in batch mode is often used to purify mAbs. One unit operation is completed at a time. A volume of mAbs is purified over a set number of cycles in a large column with a packed bed of protein A resin. The eluate from each batch is combined before virus inactivation.

  • 3-6 cycles per batch
  • Complete a single cycle in 2-4 hours
  • Protein A resin productivity: 10 – 20 g/L*h

The Next Generation of Chromatography

Conventional chromatographic matrices include, among others, resins and membranes. Mass transport in resins relies on diffusion, while in membranes, it uses convection. Both have drawbacks. Mass diffuses slowly through resins, causing low productivity. Membrane structures force users to accept a tradeoff of inversely related production factors. However, a new generation of chromatographic materials combines the structure of resins with the convection of membranes. This ensures productivity, robustness, scalability, and easy cleaning.

Learn More About Rapid A Chromatography

Featured Assets

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Frequently Asked Questions

Protein A chromatography is the most efficient stable affinity chromatography technique to concentrate and purify antibodies or Fc containing proteins in batch or continuous mode.

It is a proteinic ligand providing highly specific interaction with an antibody. It binds under mild conditions and elutes at lower pH enabling the removal of many product/process-related impurities.

It is a recombinant protein produced from mammalian cells (Chinese Hamster Ovary). It is secreted in the cell culture supernatant under perfusion or fed-batch conditions with titers up to 10 g/L.

It is a technique based on very high frequency of cycling of a quasi-flow rate independent chromatography consumable allowing much higher productivity and enabling a single-batch strategy.

Related Assets

Application Note

Sartobind® Rapid A:  High Binding Capacities at Short Residence Times

PDF | 763.0 KB
Application Note

Sartobind® Rapid A: Proven, Scalable New Membrane Platform for mAb Capture

PDF | 493.4 KB
Application Note

Sartobind® Rapid A: Comparable High Product Quality as Protein A Resins at High Productivity

PDF | 3.0 MB
Application Note

Sartobind® Rapid A:  Robust mAb Capture at High Productivity

PDF | 3.8 MB
Datasheet

Sartobind Rapid® A

PDF | 1.0 MB

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Consult Our Experts

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