Liquid Chromatography Systems Designed for Biopharma Excellence
From high-purity biomolecule isolation to large-scale purification, Sartorius delivers liquid chromatography and high-pressure liquid chromatography (HPLC) systems designed to maximize efficiency and cost-effectiveness.
- Flexibility: Liquid chromatography systems configured to your needs
- Higher Productivity: Up to 80% resin savings with continuous chromatography
- Purity and Recovery: High-resolution separation for any molecule
- Seamless Integration: Smart automation and advanced process control
Chromatography Systems Portfolio
Optimize Your Process With the Right Platform - Which Chromatography System Fits Your Goals?
- Liquid chromatography, continuous chromatography, or preparative HPLC— Sartorius makes it easy to choose the right system for your process
- Browse our high-performing solutions and find the right chromatography system for your bioprocess
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| Type of Chromatography Process | Batch liquid chromatography process for soft beads resins and membranes | Continuous or multi-column chromatography | Batch and continuous chromatography for low-pressure chromatography resins or membranes | Batch HPLC for high-pressure chromatography resin |
| Wetted Parts | Multi-use or disposable | Multi-use or disposable | Multi-use | Multi-use |
| Application | mAbs, vaccines, recombinant proteins, and gene therapy | mAbs, vaccines, and recombinant proteins | mAbs, vaccines. recombinant proteins, and gene therapy | Insulin, peptides, oligonucleotides, GLP-1, etc. |
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Supporting Products & Services
Learn More About Chromatography Systems
Empowering Bioprocesses with Proven Liquid Chromatography Solutions
Sartorius delivers advanced liquid chromatography systems for batch, continuous, and preparative HPLC. Designed for precision and scalability, our solutions enable high-efficiency separation and purification of both small and large molecules.
Whether you're running batch processes or moving toward continuous chromatography for greater productivity, Sartorius systems combine robust performance with regulatory compliance. Proven in GMP environments, they simplify complex workflows and accelerate process development.
Frequently Asked Questions
There are several types of chromatography systems, each tailored to specific separation requirements, pressure ranges, and application needs, particularly in biotechnology and pharmaceutical processes.
Low-Pressure Liquid Chromatography (LPLC): Typically operates below 6 bar.
High-Pressure Liquid Chromatography (HPLC): Operates in the 30–100 bar range.
Each system can be designed to match different processing scales and flow rates ranging from analytical and preparative to full manufacturing scale. They may be configured to run single or multiple columns depending on process complexity and throughput needs.
Continuous chromatography delivers significant efficiency gains across bioprocessing workflows:
- Increased productivity through uninterrupted processing
- Up to 80% resin savings compared to traditional batch chromatography
- Faster separation and real-time monitoring reduce overall process time
- Seamless scalability from pilot to commercial scale with consistent yield and quality
- Improved resource efficiency (by minimizing buffer and reagent consumption) and lowering operational costs
Preparative HPLC is ideal for high-resolution separations and is commonly used for purifying small molecules, peptides, and biologics such as GLP-1 and insulin. Key benefits include:
- Exceptional purity and recovery of target molecules
- Precise control over separation parameters for specific applications
- Scalability from research to large-scale manufacturing
- Versatility to handle a wide range of feedstocks, from low-volume development to high-throughput production
Sartorius provides advanced automation features that streamline liquid chromatography:
- Real-time monitoring and control to reduce variability and ensure consistent results
- Automated method development to accelerate setup and improve process reliability
- Integrated upstream and downstream processes for seamless, end-to-end efficiency
- Scalable automation that minimizes human error and maximizes overall productivity
Our chromatography systems are optimized for both large molecules (such as mAbs, vaccines, and viral vectors) and small molecules (such as insulin, GLP-1, peptides, and oligonucleotides. This allows us to support a wide spectrum of bioprocessing applications.