Connected Process with Resolute® BioSC Platform
Moving From a Chromatography Skid to Connected Downstream Processing
Connected or semi-connected downstream processing provides substantial improvements to productivity, cost, timelines, and facility footprint. Our flexible portfolio lets you choose an intensification strategy that aligns with your unique process goals.
Resolute® BioSC Pilot is a multi-step chromatography system that can continuously operate three chromatography separations (in batch or multi-column mode), including viral inactivation and in-line buffer preparation. The chaining of multiple unit operations together results in a compact and intensified process.
Simple orchestration of multiple steps by one system.
One system can replace multiple standalone units, thereby reducing footprint.
Large range of processes and flow path configurations available to design your own multi-step system.
Choose the Right Connected Configuration
Multi-Step Chromatography System
The Resolute® BioSC platform is a highly modular multi-step chromatography system designed to purify biologics (such as mAbs, recombinant proteins, blood factors, etc.). The platform can be configured to design your own multi-step process.
Resolute® BioSC Pilot | |
|---|---|
Scale | Clinical | Commercial Manufacturing |
Process Type | Continuous and intensified downstream including chromatography and virus inactivation |
Number of Columns | 1 to 6 |
Flow Rate Range | 4.98-150 L/hr (83-2500 mL/min) |
Virtual Demo of Resolute® BioSC Platform
Connected Downstream Process
Resolute® BioSC Pilot
Resolute® BioSC Pilot can connect multiple steps such as chromatography, viral inactivation and in-line buffer preparation. The chaining of multiple processes results in a streamlined and intensified process.
- Connected DSP
Allows simultaneous and continuous operation of up to three chromatography separations. These can be part of a batch and/or multi-column process - Integrated Viral Inactivation (VI)
Enables full automation and integration of the VI, as well as chromatography process management with a single skid - In-line buffer preparation
Automatically prepares buffer solutions with the right combination of pH, conductivity, and concentration from stock solutions. These three parameters are continuously monitored and controlled by a dedicated algorithm to guarantee accuracy and fast response.
Resolute® BioSC Predict
Resolute® BioSC Predict is an exclusive simulation and optimization software for the development of intensified chromatography processes, enabling scientists to easily switch from batch to a streamlined continuous process, without any prior expert knowledge.
- User-friendly software provides fast simulation results
- Automatic recipe generation for multi-column processes
- Works with Resolute® BioSC Plarform
Related Assets
Re-Imagining Chromatography - Building Efficient, Connected Downstream Processes
PDF | 2.4 MB
Integrated | Connected Downstream Processing of mAbs With Resolute® BioSC for Improved Productivity, Cost, Footprint, and Facility Utilization
PDF | 524.3 KB
