Buffer Solutions to Optimize Downstream Conditions
A consistent supply of high-quality buffers is essential for downstream processing. Tailored buffers may increase yield and efficiency. Sartorius’ global manufacturing facilities are fully comply with the highest quality and regulatory standards and provide a reliable and uninterrupted supply of powder and liquid buffers in your preferred packaging. Whether you need a standard buffer or a customized solution, Sartorius has an experienced team to guide your selection across your process.
Downstream Buffer Solutions Portfolio
Ready-to-Use Liquid Buffers
- Broad variety of formulations and concentrations
- Primary packaging from 0,5L to 1 000L Flexsafe® bags
- Qualified raw materials in highest possible grade (EP | USP | JP when applicable)
- In-house WFI-quality water loop
- Compliant to relevant manufacturing and transportation regulations
- Returnable Palletank ® service for sustainable solution
- Stability study available on demand
Buffer Concentrates
Improve handling & reduce footprint
Buffer Concentrated formulations are used at specific downstream steps for a broad variety of applications in the bioprocessing environment. Compared to regular buffers there are several advantages to concentrated buffers:
- Reduce labor work
- Cost-effective and time-saving
- Reducing the footprint
Sterile-Filtered WFI-Quality Water for Laboratory & Manufacturing Use
Water For Injection (WFI)-Quality Water is aseptically processed from a validated WFI system that meets current USP and EP specifications.
- Increase capacity instantly: Ensure continuous access to compliant WFI-quality water
- Simplify validation: Supplied in Flexsafe® bags with Certificate of Analysis and samples for incoming goods testing
- Meet the highest quality standards: Manufactured under certified ISO 13485 and ISO 9001 and in accordance with cGMP guidelines
- Maintain stored supply: Two-year shelf-life
- For hydration of cell culture media and buffers, rinsing of equipment or surfaces, downstream processing steps such as clarification and chromatography
Strong Acids, Bases, Alcohols and Detergents
Sartorius offers off-the-shelf NaOH 1M in 20L Flexsafe® Bag for a wide variety of applications.
Strong Acids Bases, Alcohols and Detergents are critical in downstream processing:
- Used for Media & Buffer prepration, pH adjustement, Chromatography steps, Virus Clearance, Inactivation & Equipment cleaning.
- Proven chemical compatibility with Flexsafe® film
- Documentation for dangerous goods is available
Learn More About Buffer Solutions
Integrated Approach of Buffer Preparation
Simplify Sourcing and Logistics Thanks to a Comprehensive Offering
Buffer Solutions Across Downstream Processes
Media & Buffer Preparation
Sartorius powder media and buffers can be prepared and hydrated with WFI-quality water.
Media & Buffer Preparation with Flexsafe® Pro Mixer
The Flexsafe® Pro Mixer, pre-weighed powder buffers, and powder transfer bags ease buffer preparation for downstream processing.
Acids, Bases, Alcohols for DSP Steps
Strong acids, bases, alcohols and detergents support chromatography and purification steps in downstream process.
FAQs - Buffer Solutions
Buffer solutions can neutralize small amounts of added acid or base, maintaining the solution at a relatively stable pH. This is important for reactions and processes which require specific and stable pH ranges. For example, a change in pH disrupts hydrogen bonds, changing the shape of a protein and impacting the quality of the final product.
Water conductivity is used to measure the purity of bulk purified Water (PW) and Water for Injection (WFI) for the pharmaceutical industry. Conductivity measurements indicate the quantity of dissolved ions present in a water sample and can be used to determine water quality.
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Related Topics
Ensuring Buffer Quality
Meeting quality standards starts with approved raw materials obtained from qualified vendors.
- Super-quality materials with complete NAO (non-animal origin) traceability are used.
- Buffers, WFI-Quality Water & Dangerous Goods production systems meet both US and European Pharmacopoeia standards.
- Finished products undergo tests for sterility, osmolality, pH, and endotoxin content
Broad Capacities for Downstream Buffer Solutions
Buffer needs and volumes can become very large as processes grow and Sartorius is well-equipped to work with you on minimizing the burden associated with transport logistics by providing an extensive array of ready-to-use downstream processing buffers for protein and viral-based therapeutics.
Customized Solutions for Unique Needs
Sartorius’ production-focused buffer solutions are ideal for clients with known, desired media composition and outcome expectations. Sartorius established a global network of qualified suppliers. Customized packaging, buffers, WFI formats, dangerous goods formats, and release assays are available on request.