Process Intensification for Chromatography

Increasing diversity of modalities, demands for low product volumes and the push to lower drug prices as well as cost of goods are major factors driving the industry towards process intensification. Advancements and increased adoption of upstream process intensification strategies has led to higher titers making the handling of these titers downstream challenging. Reducing downstream bottlenecks as well as increasing flexibility to switch easily and quickly from one campaign to another are major drivers for chromatography process intensification. Benefits of intensified and continuous chromatography include:

  • Increased productivity of the chromatography step(s)
  • Reduced footprint (fewer or smaller intermediate tanks)
  • Reduced consumable and buffer consumption
  • Reduced media costs (especially applicable to expensive affinity resins)

Choose the Right Solution

Find the Right System

We offer several chromatography intensification strategies such as:

  1. Intensified Batch Chromatography: Batch chromatography can be intensified using Rapid Cycling Chromatography (RCC). RCC is a process that runs several short cycles on the same membranes at higher flowrates that result in higher productivity.
  2. Multi-Column Chromatography (MCC): A process where one large column is replaced with multiple small columns that are processed simultaneously delivering a faster and vastly more efficient purification.
  3. Multi-Step Chromatography: A connected process where multiple process steps are consolidated within one system and these steps are run simultaneously.

Each of these options is fully scalable for your manufacturing requirements. These are supported by a global field application services team with experts who can provide installation and application support.

Intensified Batch

Multi-Column Chromatography

Multi-Step Chromatography

Step Type

Intensified, standalone unit operation

Intensified, standalone unit operation

Connected unit operations
(intensified or not)


Simplicity (no column handling), higher productivity and speed to clinic

Higher productivity, lower resin volumes and cost, and lower buffer consumption

One system can replace multiple standalone units leading to savings in CAPEX, time and footprint

Typical Applications

RCC: Affinity
Membranes: Affinity, ion exchange


Affinity, ion exchange and flow through


Resolute® Flowdrive SU,
Resolute® RCC MU

Resolute® BioSMBResolute® BioSC

Single-Use or Multi-Use Systems




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Intensified Batch Chromatography

Intensified chromatography using Rapid Cycling offers extremely high productivity compared to traditional batch chromatography, optimal media utilization, elimination of column handling and associated labor-intensive as well as contamination-prone processes.

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Multi-Column Chromatography

Multi-Column Chromatography using Resolute® BioSMB platform enables higher productivity compared to traditional batch chromatography, significant reduction in resin volumes and thus lower resin costs. It can be applied to both a DSP batch and a DSP continuous process

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Multi-Step Chromatography

Multi-Step Chromatography using the Resolute® BioSC platform allows a connected process, consolidating multiple unit operations  (chromatography, virus inactivation and inline buffer preparation) within one system, enabling significantly lower CAPEX, time, and footprint.

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Related Webinars

Want to Remove the mAb Capture Bottleneck?

See first-hand how Sartobind® Rapid A delivers a tenfold increase in productivity with Sartorius’ new chromatography membrane. Learn more about the product’s scalability, from PD to commercial, and how to remove the mAb capture bottleneck in this webinar.

Watch Now

The Medicine Maker Webinar: Downstream Process Intensification

Join Sartorius as we explore solutions for downstream process intensification. Our experts will discuss key technologies such as chromatography.

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Related Assets


(Re)Defining Process Intensification

PDF | 343.7 KB

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