Intensification Solutions for Process Development

Cell Line Development & Media Prep

Design a process intensification approach that accelerates development timelines, improves cell performance, and supports scalable, high-yield mAb production by combining optimized CHO lines with high-throughput screening and automation.

Highlight products:

CLD services: Speed up your time-to-clinic with our cell line development, protein characterization, cell bank manufacturing, and biosafety testing.

4Cell^® SmartCHO Media: Enable robust performance for batch and fed-batch processes in DG44, K1, S, and GS cell lines.

Media Testing Services: Get support from our media experts whether you’re adapting, developing, or optimizing your formulation.

Ambr^® 250 High Throughput Generation 2: Catalyze process intensification, cost optimization, and digital transformation.

StreamLink^® CC 15: Simplify mAb bioreactor sampling without compromising quality.

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Reduce resin use, buffer consumption, and processing time while streamlining scalability with process intensification. You can leverage real-time monitoring and process analytical technologies to enhance control and efficiency, helping ensure consistent product quality while streamlining downstream operations.

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Resolute^® BioSMB for MCC: Easily integrate from existing batch processes, improve resin use, and reduce costs by up to 80%.

Sartobind^® Rapid A Membrane: Cut up to 80% of non-productive column-use activities, and save more than 60% on process costs in clinical-scale production when compared to traditional resin chromatography.

Confidence^® Validation Services for Virus Clearance: Accelerate your path to LRV results with GLP virus clearance studies for any purification technology, as well as consultations with experts.

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Virus Filtration, Polishing & Ultrafiltration

Accelerate optimization and enable robust impurity clearance with advanced modeling, high-throughput screening, and real-time analytics. These strategies not only improve process efficiency and consistency, but also ensure compliance with regulatory expectations for viral safety and product quality.

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Single-Pass TFF: Reduce processing and setup time by 66%, system footprint up to 50%, and buffer usage by 15% — all while increasing efficiency by a magnitude of 1.5 compared to classic TFF methods.

Sartobind^® Chromatography Membranes: These adsorptive membranes transform your chromatography flow rates that are 150X faster than traditional columns.

HyperCel Mixed Mode Resins: Achieve higher selectivity and purity in a single step than traditional single-mode chromatography with multi-modal separation mechanisms like IEX and HIC.

Confidence^® Validation Services for virus clearance: Accelerate your path to LRV results with GLP virus clearance studies for any purification technology, as well as consultations with experts.

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Digital Solutions and Data Analytics 

Enhance efficiency, reduce development timelines, and lay the groundwork for smarter, more adaptive biomanufacturing processes by modernizing your facility with advanced IT solutions. 

Highlight products:

Biobrain^® Automation Platform: Benefit from reliable hardware and software that offers flexibility and configurability while maintaining full traceability. 

Biobrain^® Supervise: Enable flexible plug-and-play connectivity along with data acquisition and historization, comprehensive process monitoring, and advanced recipe control for all upstream and downstream processes.

Umetrics^® Digital Twin AI Ecosystem: Access powerful, easy-to-use tools that can optimize your manufacturing processes and bring quality products to market faster.

Umetrics^® Digital Twin MODDE^® Design of Experiments: Increase productivity and tackle your toughest challenges in development and manufacturing by applying design of experiments quickly and cost-effectively. 

Umetrics^® Digital Twin Cell Insights: Take your experiments further by expanding on information from in vitro experiments with in silico simulations.

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