In-Silico Simulations. Actionable Insights.
Cell Insights by Umetrics® Studio, an advanced data analytics application, expands on in-vitro experiments with in-silico simulations in a virtual bioreactor, accelerating time-lines and decreasing costs.
Virtual bioreactors reduce the number of experiments in upstream cell culture process development by generating accurate in-silico predictions.
Ensure optimal cell culture performance, regardless of the cell-based modality and independent of the bioreactor brand and model.
Enhance decision-making by coupling in-vitro cell culture experiments with machine learning and mechanistic knowledge of cell behavior and metabolic pathways.
Predeveloped simulation workflows with easy-to-use interfaces enable access to advanced modeling and artificial intelligence (AI) beyond data scientist levels of expertise.
Running digital operations in a cloud-native environment minimizes IT support by enabling fast and easy maintenance, scale-out and upgrades.
Cell Insight by Umetrics® Studio Use Cases
Cell Insights by Umetrics® Studio is an advanced data analytics application that uses hybrid models to generate bioreactor simulations. It supports a variety of cell-culture development use cases:
Choose the best perfusion cell line
Quickly forecast performance in fed-batch, perfusion and N-1 cell culture methods to choose the best perfusion cell line without having to perform multiple in-vitro experiments.
Select cell culture process parameters
Save time by using hybrid modeling to understand how process parameter adjustments impact cell growth, metabolism, and productivity.
Optimize perfusion media
Rely on in-silico simulations to know how perfusion media composition and exchange rates impact cell growth to quickly design optimal perfusion protocols.
Set up your seed train configuration
Minimize experiments to learn how seed duration, number of passages, and culture methods impact cell growth to design optimal seed train configurations.
FAQs
A bioreactor simulation is an offline, model-based representation of a bioreactor operation. Simulations can represent multiple or single events that occur during a bioreactor process and are typically used for design and optimization projects.
A bioreactor digital twin is a virtual environment that serves as the real-time digital counterpart of a physical bioreactor process. Within a bioreactor digital twin all types of simulations can be run and are typically represented in 2D or 3D.
Hybrid modeling is a method which uses multiple modeling techniques in the same workflow. The hybrid models in Cell Insights by Umetrics® Studio combine first-principal knowledge about cell kinetics and metabolism with data-driven information to generate new information about how cells perform under different conditions and events.
The term in-silico stems from the computer component silicium. In-silico methods, therefore, refer to methods or predictions using computational approaches.
Yes, Cell Insights by Umetrics® Studio can be used to model any cell-based processes (incl. HEK, CHO, CAR-T cells, microbial and bacterial cultures, and cells on microcarriers) so long as it follows Monod growth kinetics.
To perform basic simulations the following is data is needed:
- Perfusion Cell Line Selection | viable cell density (VCD) and viability measurements.
- Virtual Bioreactor | viable cell density (VCD) and viability measurements.
- For more advanced simulations, additional process measurements, such as temperature, pH, DO, etc. as well as metabolite (glucose, lactate, etc.) and feed data should be included.
An advanced data analytics ecosystem is a single touchpoint for data analytics and management. The ecosystems contain all the necessary tools to ingest, prepare, and discover from data.
Cloud-native technologies empower organizations to build and run scalable tools in private, public, or hybrid cloud environments.
The Umetrics® Studio Data Analytics Ecosystem
Umetrics® Studio is a cloud-native data analytics and management ecosystem that enables both model building and investigation as well as data storage, visualization, and transformation for advanced insight generation. Through the seamless Umetrics® Studio digital experience, process development and commercial manufacturing teams can put standard analytics processes in place, eliminate silos of data analytics, and promote information sharing and collaboration across departments. Umetrics® Studio offers organizations the opportunity to maximize knowledge, optimize performance, and cut timelines and costs via a single touchpoint.
The Umetrics® Studio data analytics ecosystem contains three main components:
Umetrics® Insights Applications
A growing library of solution-focused applications with predefined workflows and dedicated interfaces. Cell Insights is the first available Insights application. Future Insights applications will be uploaded, distributed, and purchased through the Umetrics® store.
Umetrics® Scibox
Offers a range of predeveloped tools for generic data analysis as well as the power to create your own automated analytics workflows using easy-to-use visual programming. Umetrics® Scibox enables users to process, visualize, model, analyze, and share data for improved planning and decision making.
Umetrics® Codebox
Application programming interface (API) that enables organizations, partners, and internal Sartorius divisions to build custom Umetrics® Studio integrations and applications.
Highlight Assets
Umetrics® Scibox Create
The Create functionality within the Umetrics® Scibox enables the development of customized workflows that can be deployed through Umetrics® Studio as applications to other users within the organization.
Watch this video to get a preview of the Umetrics® Scibox Create functionality.
Umetrics® Scibox Explore
The Umetrics® Scibox provides a powerful toolset to data scientist to process, visualize, model, and analyze data.
The Explore functionality within the Umetrics® Scibox allows to perform model-assisted system exploration and understanding to quickly justify acceptable ranges and quality differences and link process parameters to quality attributes.
Watch this video to get a preview of the Umetrics® Scibox Explore functionality.
