Time To Intensify | Sartorius

On-Demand Webinar | Time to Intensify: Taking Process Intensification of mAb Manufacturing to the Next Level

Process intensification (PI) enhances the efficiency, flexibility, and sustainability of complex molecule manufacturing by reducing costs and increasing throughput. That is why the monoclonal antibody (mAb) industry is shifting from traditional manufacturing methods to intensified processes. In this space, PI improvements began with single-use facilities, continuous manufacturing, and upstream processing advancements aimed at boosting mAb titers and productivity. However, this shift has highlighted bottlenecks in downstream processing, necessitating a more comprehensive PI approach that spans both upstream and downstream manufacturing processes.

In this GEN on-demand webinar, Gerben Zijlstra, PhD, and Jean-Marc Cappia, both experts in process intensification, explore the significance of PI in mAb production, emphasizing its impact on productivity, sustainability, and resource consumption. They will outline innovative PI strategies, expert guidance tools, and technologies that are available to simplify PI, including continuous perfusion bioreactors, advanced membrane chromatography, and viral inactivation techniques. They will also highlight the role of data analytical tools, process analytical tools, and automation software in supporting this transition. A series of industry case studies will show how modern manufacturers leverage PI for efficient, cost-effective, and sustainable mAb production.

What You Will Learn:

Learn how to select the best end-to-end intensification strategy to suit your needs.
Discover scalable intensification technologies and automation platforms.
See how we can help streamline your integration of intensification technologies.

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Jean-Marc Cappia

Head of Market Development Intensified Chromatography

J.M. Cappia is Head of Market Development, Intensified Chromatography, at Sartorius, based in Aubagne, France. A Biotechnology Engineer graduate from INSA Toulouse with more than 35 years of experience, Mr. Cappia supports the biopharmaceutical industry globally, particularly in process design, process intensification, validation, training, and implementation of single-use filtration, purification, and fluid management technologies.

Since joining Sartorius in 2006, he has been responsible for marketing, product management, and business development for emerging single-use technologies. In his current position, he supports the biopharmaceutical industry in implementing downstream process intensification, focusing on chromatography, with the objective of producing safer and more cost-effective biologics in more sustainable manufacturing facilities.

Gerben Zijlstra, PhD

Bioprocess Solutions Expert

Gerben Zijlstra is a leading expert in process intensification, integration, and continuous biomanufacturing, with over 25 years in the BioPharma industry. He holds a Ph.D. from the University of Wageningen, focusing on process integration in animal cell culture. At Patheon, he developed commercial biotherapeutics and advanced Process Intensification projects with Single Use bioreactors. Zijlstra invented the XD^® Concentrated Fed-Batch technology, boosting productivity fivefold, and facilitated its scale-up to the Brisbane site, recognized by ISPE for process innovations. At Xendo, he worked on SU Continuous BioManufacturing and Gene Therapy projects. Currently, he is a Bioprocess Solutions Expert at Sartorius.