Automated, High-Throughput Sample Preparation of mAb-Expressing Cell Cultures
Introducing the Sartorius StreamLink® CC 15: The next generation in cell line and process development. Simplify mAb bioreactor sampling without compromising quality with an automated high-throughput system that offers fast clarification and purification of 5-15 mL samples ready for CQA analysis. Process 24-48 samples directly from Ambr® 15 | Ambr® 250 bioreactors to cut processing time from days to hours and reduce manual input from 6 hours to just 10 minutes.
Fully “walk-away” automated, mAb-expressing cell culture sample preparation reduces operator hands-on time from 6 hours to 10 minutes.
The high-throughput system is designed to clarify and purify 24 mAb samples for CQA analysis in just 2-4 hours, and has the capacity to prepare 48 Ambr® 15 samples in a single experiment.
The compact, all-in-one benchtop system supports a simplified mAb sample preparation process, enhancing ease of use and reducing the potential for errors.
Leverage representative chromatography and data-driven process insights to support process development and enable earlier clone selection parameters.
Full flexibility to clarify, purify, neutralize, and aliquot depending on your needs at any stage in the mAb development process.
Walk-Away Bioreactor Sampling
The fully automated, reproducible, high-throughput process is based on optimized protocols to ensure quality. When combined with integrated error recovery, upstream mAb sample preparation becomes a “walk-away” process requiring minimal operator intervention and reducing hands-on time from 6 hours to 10 minutes.
Watch the video to see how.
Overview of the StreamLink® CC 15
Automated Bioreactor Sampling: Clarify and | or Purify 24 mAb-Expressing Cell Culture Samples in 2-4 Hours
Click the signs to learn more about how the StreamLink® CC 15, an all-in-one benchtop screening system, streamlines mAb sample preparation for CQA analysis.
StreamLink® CC 15 System Benefits
Reduce Labor Requirements With Automated Walk-Away Sample Preparation
- Increase reproducibility by reducing the chance of operator error
- Cut hands-on time from 6 hours to 10 minutes
- Limit unnecessary downtime with built-in error recovery
- Save operator time with always-on sensing and simplified data reporting
Achieve Faster mAb Sample Preparation With a High-Throughput System
- Reduce process timelines by clarifying and purifying 24 mAb-expressing cell cultures in just 2-4 hours
- Boost sample preparation capacity by processing 48 samples in a single experiment
- Removing the sample preparation bottleneck to get CQAs faster
- Reduce the total time for mAb sample preparation from 2 days to 2-4 hours
Gain Detailed Process Insights at Lab Scale
- Unlock new clone selection parameters with a representative clarification process using the Sartoclear® Disc
- Get earlier clone insights using UV peak cutting for automated eluate collection with the Sartobind® Rapid A Nano
- Remove the uncertainty of manual sample preparation with always-on sensing
- Skip unnecessary steps before CQA analysis with integrated titer estimation
Simplify Sample Preparation With a One-Step Clarification and Purification Process
- Remove non-value-added manual steps with integrated neutralization and aliquoting
- Save space in the lab with a compact benchtop system
- Reduce maintenance with integrated cleaning protocols
- Eliminate repeats with automated error recovery and guided system setup
Related Assets
StreamLink® CC 15 Sample Prep Flexibility
The StreamLink® CC 15 process template can be modified to support a range of applications. Clarification and purification can be selected to run separately or combined. Define parameters such as pressure limits and flow rates to meet the requirements of different cell lines and mAbs.
