High-throughput Screening Tools to Improve and Accelerate Your Cell Line Development

Innovative Technologies to Select the Right Clone

Sartorius provides innovative, high-throughput and automated solutions for early development of dedicated cell lines. Instruments to identify top-performing cell lines with the optimal critical quality attributes (CQAs) can not only achieve high yields of recombinant proteins, but also smooth the transition to commercial manufacturing. Eliminate process bottlenecks by investing in the most advanced technologies for cell line selection, characterization, and cell bank preparation.

Watch the Video: How Biologic Therapeutics are Developed

Make Better Predictions Earlier

Early prediction of the best-performing clone means you can get it right, right from the start.

Expand Your In-house Capabilities

Advanced tools to enhance your cell line development.

Increase Efficiency

High-throughput systems reduce cost and shorten timelines for stable, scalable, productive cell lines.

Generate Clonal Cell Lines Faster

Streamline Cell Line Development with Automated, High-Throughput Instruments

For high yields of recombinant proteins for therapeutic applications, stable, scalable and high-titer cell lines are needed.  With advanced techniques and technologies from Sartorius, you can accelerate cell line selection and development, so you screen more clones faster and make decisions sooner.

iQue® for Deeper Insights Delivered Faster

The iQue® Advanced Flow Cytometry Platform with iQue® Human IgG Titer and Viability Kit provides greater insight into production clone ranking and selection, with rapid and simultaneous evaluation of IgG titer, specific productivity, and cell health.  

  • Microfluidics acquisition capability analyses samples as small as 10 μL in a 384-well format with zero dead volume. Cell detection at rates of thousands of cells per second 
  • Multiple readouts for every event 
  • Natural conformation of cells and targets

Learn More About iQue®

Octet® Label-Free Biomolecular Interaction Analysis 

Octet® BLI Label-Free Detection System eliminates issues with detailed characterization of expressed proteins, thanks to optical biosensors that measure molecular interactions in real-time without detection agents and advanced, fast, and fluidics-free direct detection of specific biomolecules.   

  • Rapidly determine product titer and binding kinetics 
  • Monitor native states label-free and in real-time 
  • Use both purified and unpurified samples 
  • Recover sample plates after non-destructive measurement

Explore Octet® BLI Label-Free Detection System

Ambr® 15 Cell Culture Generation 2: Automated Bioreactor System 

The leading microbioreactor system for cell line development and process optimization, allowing parallel operation of up to 48 single-use microbioreactors (10-15 mL), controlled by an automated workstation. 

  • Proven industry standard for high-throughput cell line development  
  • Enables rapid evaluation of multiple bioreactor cultures, increasing productivity and saving on materials and labor 
  • Provides predictive performance to larger-scale bioreactors 

Explore Ambr® 15


Fill-It: Automated Cryovial Processing for Cell Banking Applications

The Fill-It system helps create cell banks for drug discovery, screening operations and GMP production. It rapidly dispenses cell suspensions, strains or reference standards from bulk stock into the screw-cap cryovials before recapping them.  

  • Fits in a standard biosafety cabinet  
  • Facilitates easy loading and operation 
  • De-caps racks of cryovials held in either 96-, 48- or 24-vial racks. 
  • Provides automated cell banking compatible with wide microtube range

Learn More About Fill-It


Featured Resources

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Webinar: Effective Cell Line Development

Reducing Risk, Decreasing Timelines, and Optimizing Outcomes

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Cell Line Development: Accelerating Process Optimization by...

Cell line development (CLD) involves the screening of thousands of clones to find those that are stable, produce high yields of the bioproduct...

Download Application Note
Octet® R Series Glycan shadow visual

Mannose Glycans Content Screening for Human-mAb Samples

A novel approach for relative mannose content screening and ranking of human monoclonal antibody (mAb) samples using the Octet® GlyM Kit

Read Application Note

Application Note: iQue® Mouse IgG Type and Titer Assay Kit

A Novel Solution to Expedite Antibody Discovery

Read Application Note
Cell Line Development: Accelerating Antibody Discovery by Monitoring Titer and Glycosylation With the Octet® Platform

Application Guide: Cell Line Development

Accelerating Antibody Discovery by Monitoring Titer and Glycosylation With the Octet® Platform

Read Application Guide
Related Resources
Octet GlyM Kit datasheet

Product Datasheet

Datasheet: Octet® GlyM Kit - For High-throughput Screening of Crude and Purified mAb and Non-mAb Protein Samples

PDF | 768.6 KB

Technical Note

For High-Throughput Mannose Glycans Screening of Crude and Purified mAb and Non-mAb Protein Samples

PDF | 2.2 MB

Brochure

Ambr® 15 Cell Culture Generation 2

PDF | 3.8 MB

Application Note

A Rapid Method to Quantitatively Screen Bispecific Antibody 

PDF | 726.9 KB

Application Note

A single, multiplexed assay that simultaneously quantifies IgG isotype, IgG quantity per isotype, total IgG secretion, cell count and cell health

PDF | 1.5 MB

Brochure

Advanced, high-throughput flow cytometry solution to speed up your entire workflow 

PDF | 3.2 MB

Brochure

Automated cell banking system to create cell banks of higher quality, consistency and viability 

PDF | 1.4 MB

Data Sheet

Facilitated production of a cell bank using an automated cryovial dispenser 

PDF | 3.5 MB

Brochure

Generation 2 automated bioreactor system to accelerate cell line development 

PDF | 5.2 MB

Brochure

Technologies to ensure your confidence in every stage of the biologic’s discovery and development process 

PDF | 3.8 MB

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