Select the Right Products and Services for Your Unique Process

A Tailored Approach to Cell Line Development 

Bringing a biologic to market depends on smart cell line development strategies. You need to balance the control and speed of an in-house solution with the convenience and flexibility of outsourcing. Sartorius offers a suite of innovative products and services that can be tailored to your operation.  Whether you need instruments, consulting, or development and testing services, partnering with Sartorius can accelerate your cell line development and ensure a smooth transition to commercial manufacturing. 

Maximize Your Strengths

Choose just the right products and services to complement your core strengths

Maintain Flexibility 

Leverage the right people and products when and where you need them

Streamline to a Single Vendor 

A single-vendor approach simplifies management and administrative activities

Accelerate Your Cell Line Development at Every Step 

Producing biologics is complex, and cell line development is no exception — tight timelines, constant cost pressure, and time-to-market are top of mind. Starting with customizable solutions from Sartorius gives you the flexibility to select what’s right for your therapeutic development.  

Gene Cloning and Initial Clone Selection

Accurate, Rapid Cloning and Initial Clone Selection

We offer instruments and technologies to assist with transfection and clone selection. Our innovative solutions enable rapid selection of top pools after gene cloning and can help evaluate overall clone performance, from protein concentration to cell health and viability.

Quantitate Cell Count and Viability Efficiently and Accurately

Use cell count and viability information to select the best pools. The iQue® Advanced Flow Cytometry Platform provides accuracy across a large linear range in 96- and 384-well plates and reproducible analysis of absolute cell count and viability data from a variety of non-adherent cell lines with a streamlined workflow, from cell labeling to analysis, with no cell dilution required. 

  • An integrated instrument, software, and reagent system for rapid, multiplexed analysis 
  • A unique patented sample introduction method that minimizes sample size requirements 
  • Deliver content-rich results in just minutes

Learn More About iQue® Platform

Quantitate Cell Count and Viability Efficiently and Accurately

Replace ELISA and HPLC with Octet® Label-Free Detection Systems for quantitation of antibodies and recombinant therapeutic proteins. Accurate and fast assays in real-time are easy to develop and transfer to QC and process development. 

  • Analyze a full plate (96-samples) of IgG titer in as little as two minutes 
  • Assay directly in crude and unpurified samples 
  • Optional automation for walkaway high-throughput analysis

Learn More

Monitor Transfection Efficiency 

Monitor and quantify the efficiency and time course of gene transfection using green fluorescent protein (GFP) and red fluorescent protein (RFP) markers. Incucyte® Live Cell Analysis Systems use integrated image processing to identify wells containing emerging colonies.

Learn More About Transfection Efficiency Monitoring

Produce a High-Quality, Antibody-Secreting Clone Using a Proven Process 

Sartorius’ cell line development services are targeted to large-scale production of biopharmaceuticals in mammalian cells, primarily Chinese hamster ovary (CHO) cells. The unique Cellca Cell Line Development service offers speed and flexibility, with a track record of performance and scalability. 

  • From DNA to fully characterized RCB in 14 weeks 
  • More than 120 projects successfully completed  
  • Save 3 months by omitting scalability studies 
  • Easy and direct scalability from small scale to 2000 L 

Learn More About CLD Services

Picus® Electronic Pipette

Multichannel pipettes consistently and ergonomically deliver precise and accurate volumes.

Discover Electronic Pipettes
Cell Line Selection and Confirmatory Analytics

Expansion and Screening to Identify the Highest-Performing Clones 

Early screening of product quality attributes in addition to quantity can facilitate the selection of clones to avoid late-stage failures. Ensure success by selecting the best clones based on quality and quantity using our instruments and package of ready-to-use assays and platform method.

High-throughput Glycan Screening and Protein Quantitation  

Accelerate antibody discovery by combining titer data with sialic acid or mannose data for more informed decisions. Our glycosylation kits can screen and quantify proteins in crude and purified samples. 

  • No sample purification or digestion required 
  • Reduce preparation time up to 3 hours  
  • Screen for samples with desired glycosylation profiles 
  • Prevent late failures by moving higher-quality candidates downstream  

Explore Octet® Glycosylation Kits


Rapidly Screen Antibody-Producing Clones 

Combine IgG quantification, cell counting and viability measurement in a single well without sample dilution. Quickly and efficiently learn critical productivity attributes for each clone: 

  • More insight for better clone selection 
  • More critical productivity attributes  
  • More clones screened in less time 

Discover iQue® Cell and Bead-Based Kits

Confirmation of Monoclonality 

Use whole-well, label-free imaging to automatically scan for clones and verify monoclonality. Integrated image processing identifies wells containing emerging colonies, allowing for the rapid identification of clones of interest. 

Learn More About Dilution Cloning

Cell-Based Assays

Ready-to-use and customizable cell-based assays save time characterizing biological activity and potency.

Discover Cell-Based Assays

Binding Assays

Cost-effective, ready-to-use, and custom binding assays contribute to the comprehensive characterization of your product.

Discover Binding Assays

Picus® Electronic Pipette

Multichannel pipettes consistently and ergonomically deliver precise and accurate volumes.

Discover Electronic Pipettes
Cell Line Cultivation and Media Optimization

Quickly Produce Higher Protein Titers

Improved culture conditions and enhanced culture analysis give rise to optimized cell environments that maximize cell growth and metabolism. Sartorius offers a range of products and expertise to help you improve productivity and quality, enhance stability and reduce cost.

Quickly Produce Higher Protein Titers  

Process parameters, cells and cell culture media interact in a challenging way to define the productivity and quality of the protein output. Sartorius ensures you get it right the first time, providing process-integrated media services to benefit your upstream process and reduce your time-to-market. 

Explore Media Optimization

Rapid Evaluation of Multiple Bioreactor Cultures at Microscale 

The leading bioreactor system for cell line development and process optimization, Ambr® 15 allows parallel operation of up to 48 single-use microbioreactors (10-15 mL) controlled by an automated workstation. It increases productivity in cell line development with significant savings on materials and labor. 

  • Proven industry-standard microbioreactor for cell culture 
  • Better scale-down model than a shake flask 
  • High throughput and cost-effective 

Discover Ambr® 15 Cell Culture 

Rapidly Determine Recombinant Protein Concentration as a Control Parameter  

The Octet® BLI platform is an easy-to use, real-time biologics analytical tool that requires no labeling and enables rapid screening of critical quality attributes earlier in the decision-making process. 

  • Monitor titers before and after new conditions are introduced — e.g., supplements in cell growth media 
  • Measure directly in unpurified samples such as cell culture supernatants  
  • Process the sample plates further, thanks to non-destructive measurement 

Learn More About Protein Analysis


Simultaneous Screening for IgG Titer and Cell Health Attributes 

Combine IgG quantification, cell counting, and viability measurement in a single well without sample dilution. Quickly and efficiently learn critical productivity attributes for each clone: 

  • More insight for better clone selection 
  • More critical productivity attributes  
  • More clones screened in less time 

Learn More About Bioprocessing

Sartoclear® Dynamics Lab V Kits

Clarification and sterile filtration in one step.

Explore Sartoclear® Dynamics Lab V Kits

Vivaflow®, Vivaspin® and Vivapure® Ultrafilters

Concentration, purification, and diafiltration of proteins.

Discover Ultrafiltration Devices

Picus® Electronic Pipette

Multichannel pipettes consistently and ergonomically deliver precise and accurate volumes.

Discover Electronic Pipettes
Cell Line Evaluation and Characterization

Quantify Protein of Interest and Screen Critical Quality Attributes

A suite of instruments and services evaluate selected clone(s) for contaminants, viruses, sterility, and protein production. A key aspect is defining Critical Quality Attributes (CQA) and monitoring these closely to ensure the characteristic attributes of the protein remain intact.

Rapidly Quantify the Protein of Interest and Screen Critical Quality Attributes 

The Octet® BLI platform is an easy-to use, real-time biologics analytical tool that requires no labeling and enables rapid screening of critical quality attributes earlier in the decision-making process.  

  • Monitor titers before and after new conditions are introduced — e.g., supplements in cell growth media 
  • Measure directly in unpurified samples, such as cell culture supernatants  
  • Process the sample plates further, thanks to non-destructive measurement 

Discover  Octet® BLI Platform


Simultaneous Screening for IgG Titer and Cell Health Attributes 

Combine IgG quantification, cell counting and viability measurement in a single well without sample dilution. Quickly and efficiently learn critical productivity attributes for each clone: 

  • More insight for better clone selection 
  • More critical productivity attributes  
  • More clones screened in less time 

Discover iQue® Cell and Bead-Based Kits

Sartoclear® Dynamics Lab V Kits

Clarification and sterile filtration in one step.

Explore Sartoclear® Dynamics Lab V Kits

Microsart® AMP Mycoplasma Kit

Testing for Mycoplasma contamination.

Discover Microsart®

Vivaflow®, Vivaspin® and Vivapure® Ultrafilters

Concentration, purification, and diafiltration of proteins.

Discover Ultrafiltration Devices

Picus® Electronic Pipette

Multichannel pipettes consistently and ergonomically deliver precise and accurate volumes.

Discover Electronic Pipettes
Cell Banking

Cell Banking Platform and Services to Create a Single Source for Manufacturing

Fully characterized, documented, homogenous master cell banks and working cell banks are critical to mitigate risk and ensure product safety and quality. Sartorius CHO cell banking platforms allows technology transfer of your own cell culture parameters without the need for engineering or pilot runs for an easy pivot to cGMP manufacturing.

Closed-System Cell Bank Manufacturing Platform 

Our experienced team offers you the flexibility to do your cell bank manufacturing with us. Sartorius CHO cell banking platform allows technology transfer of your cell culture parameters into the platform without engineering or pilot runs.  

  • Dedicated cGMP facility 
  • Standard >500 vials, 12 x 106 viable cells/cryovial 
  • Closed and automated single-use 
  • Flexibility of transfer to any CMO 
  • Qualified Person (QP) batch release 
  • FILL-IT® automated filling: 500 vials in 20 minutes 


Explore Cell Banking

Cell Bank Biosafety Testing and Characterization Packages 

Add ready-to-use testing schemes to existing drug development risk strategies or customize them. Sartorius QC testing plans meet mammalian cell bank release requirements and ICH Q5A regulations with GMP-validated assays. Sartorius has performed testing on over 200 CHO cell banks, so you can count on our experienced scientists to recommend the most suitable — and cost-effective — testing strategy to meet regulatory requirements.   

  • Expand QC workbench capacity and scientific expertise 
  • Accelerate time to market with rapid PCR or ELISA assays  
  • Gain access to testing experts 

Discover Cell Line Characterization


Related Resources

Explore Our Related Resources for Cell Line Development  

Sartorius is a leading provider of cell line development solutions and services targeted to large-scale production of biopharmaceuticals in mammalian cells. Keep reading below to learn how we can help you on your journey to a master cell bank.

Ultrafiltration

Critical sample preparation to concentrate hybridoma supernatants

PDF | 213.9 KB

Biologics Drug Discovery

Ensure your confidence in every stage of discovery and development 

PDF | 1.2 MB

Octet® Glycosylation Kit

Improved CLD monitoring of titer and glycosylation in the same sample

PDF | 362.2 KB

Mycoplasma Detection

Mycoplasma Detection with Microsart® Mycoplasma qPCR Kits ensure validated test results in compliance with international standards 

PDF | 617.3 KB

Cell Culture Harvesting

Overcome high density cell culture harvesting issues

PDF | 2.2 MB

Octet® Label-free BLI Systems

Rapid method to quantitatively screen bispecific antibody 

PDF | 726.9 KB

iQue® IgG Kits

Quantify IgG isotype, IgG quantity per isotype,  secretion, cell count/health 

PDF | 1.5 MB

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