Octet® BLI Biosensors and Kits

For a Diversity of Biomolecular Applications

Octet® Bio-Layer Interferometry (BLI) Biosensors Are:

  • Ready-to-use with a fluidics-free design
  • Available in a wide range of surface chemistries for use in a diverse set of biomolecular applications
  • Coated with a proprietary biocompatible matrix that is uniform and non-denaturing with minimal non-specific binding

Biosensors can also be customized for unique applications. Multiple layers can be bound and detected, opening a vast array of approaches to detecting and characterizing biological interactions. To date, several million biosensor assays have been run on Octet® BLI systems, attesting to the high reproducibility, accuracy, precision and robustness of the platform. All sensor tips are manufactured in an ISO 9001:2008 certified facility.

Rapid Quantitation of AAV Capsids in Bioprocess Development for Gene Therapy Using Octet®️ BLI

Rapid Quantitation of AAV Capsids in Bioprocess Development for Gene Therapy Using Octet®️ BLI

Adeno-associated virus (AAV), with low immunogenicity and toxicity, has become one of the most promising viral vectors used for delivery of genetic material in gene therapy. AAV vector development and production at industrial scale requires an efficient method for accurate quantitation of viral capsids in both upstream and downstream bioprocessing.

Octet® Bio-Layer Interferometry (BLI) systems in combination with the Octet® AAVX Biosensors offer a rapid, label-free, and high-throughput method for quantification of AAV capsids. This video compares the Octet® AAVX biosensor workflow to that of ELISA at various stages in bioprocess development.

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Biosensors and Kits

BLI Detection Kits

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Anti-CHO HCP Detection Kit

For CHO Host Cell Protein Detection

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Residual Protein A Detection Kit

For Quantitation of Leached Protein A in Bioprocess Samples

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GlyM Kit

High-Throughput Screening of Crude and Purified Monoclonal Antibodies (mAb) and Protein Samples

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Sialic Acid (GlyS) Kit

High throughput Glycan Screening of Crude and Purified Samples

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BLI Biosensors

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Octet® AAVX Biosensors

For Quantitation of Adeno-Associated Virus Capsids

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Octet® AHC2 Biosensors

2nd Generation Anti-human IgG Fc Capture Biosensors for Quantitation and Kinetic Characterization of Human IgGs

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Octet® AHC Biosensors

For Label-Free Immobilization and Subsequent Kinetic Characterization of Human IgG or other Human Fc-containing Proteins

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Octet® AHQ Biosensors

For Determination of Antibody Concentration

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Octet® AMC Biosensors

For Immobilization and Subsequent Kinetic Characterization of Mouse IgGs and other Fc-Containing Proteins

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Octet® AMQ Biosensors

For Determination of Antibody Concentration

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Octet® APS Biosensors

For Hydrophobic Immobilization of Proteins

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Octet® AR2G Biosensors

EDC/Sulfo-NHS Based Immobilization for Kinetic Characterization of Primary Amine Containing Biomolecules

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Octet® FAB2G Biosensors

For Label-Free Detection, Quantitation, and Kinetic Analysis of Human Fab and IgG

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Octet® GST Biosensors

For Quantitation and Kinetic Characterization of GST-tagged Biomolecules

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Octet® HIS1K Biosensors

For Label-Free Quantitation and Kinetic Analysis of His-Tagged Recombinant Proteins

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Octet® HIS2 Biosensors

For Label-Free Quantitation of HIS-tagged Proteins

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Octet® NTA Biosensors

For Quantitation and Kinetic Characterization of HIS-tagged Biomolecules

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Octet® ProA Biosensors

For Determination of Antibody Concentration

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Octet® ProG Biosensors

For Determination of Antibody Concentration

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Octet® ProL Biosensors

For Whole Molecule Antibody and Antibody Fragment Quantitation

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Octet® SA Biosensors

For Kinetic Analysis, Screening, and Quantitation of Most Proteins

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Octet® SSA Biosensors

For Analysis of Small Molecule-Protein Interactions and Fragment Screening

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Octet® SAX Biosensors

For High Precision Quantitation and Kinetic Analysis

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Octet® SAX2 Biosensors

For High Precision and Reproducible Kinetic Characterization and Custom Quantitation

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Educational Resources

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Octet® Publication Database

Literature references covering a large variety of research areas and applications

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Application Note

Octet® AMC2 Biosensors Application Note

This application note discusses the key advantages of the Octet® AMC2 Biosensors and presents data generated at multiple user sites.

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Octet® AAVX Biosensors for Rapid and Direct Quantitation of AAV Capsids
Application Note

Octet® AAVX Biosensors

For Rapid and Direct Quantitation of AAV Capsids

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CHO Host Cell Protein Detection
Technical Note

CHO Host Cell Protein Detection

Designed for a rapid high-throughput quantitation of residual CHO Host Cell Proteins (HCPs) in bioprocessing samples during production and development...

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Application Note

Mannose Glycans Content Screening for Human-mAb Samples

A novel approach for relative mannose content screening and ranking of human monoclonal antibody (mAb) samples using the Octet® GlyM Kit

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Technical Note

Octet® AHC2 Biosensors

For Quantitation and Kinetic Characterization of Human Fc-Region Containing Proteins

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Application Note

Second Generation Anti-Human IgG Fc Capture Biosensors

For Affinity Characterization of Human IgG-Antigen Interactions and Quantitation of Human IgGs or Human Fc Region Containing Proteins 

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A Rapid Method to Quantitatively Screen Bispecific Antibodies Using Protein A and Octet® His1K Biosensors
Application Note

A Rapid Method to Quantitatively Screen Bispecific Antibody

Using Protein A and His1K Biosensors

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Application Note

Customized Quantitation of Recombinant Therapeutic Proteins

Using Octet® SAX Biosensors

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Octet® High Precision Streptavidin 2.0 (SAX2) Biosensors
Technical Note

High Precision Streptavidin 2.0 (SAX2) Biosensors

Streptavidin is often deployed as the molecule of choice for covalent linking to solid surfaces for ligand binding assays applications.

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Application Note

MAb Quantitation Protein A HPLC vs Protein A Bio-Layer Interferometry

Rapid, accurate and cost-effective quantitation of monoclonal antibodies (MAbs) is essential for bioprocessing.

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Product Resources

Technical Note

Analysis of FLAG Proteins on the Octet®️ BLI Platform Using SAX or SAX2 Biosensors

PDF | 901.4 KB
Flyer

Octet® AT: For Octet® BLI Biosensor Transfer

PDF | 736.8 KB
selection guide
Flyer

Octet® BLI Biosensor Selection Guide

PDF | 404.8 KB
Octet®️ AMC2 Biosensors: For Quantitation and Kinetic Characterization of Murine IgG Antibodies
LPS-Bioanalytics

Octet®️ AMC2 Biosensors: For Quantitation and Kinetic Characterization of Murine IgG Antibodies

PDF | 948.9 KB
Octet AAVX Biosensors for Quantitation of AAV Capsids
Technical Note

Octet® AAVX Biosensors for Quantitation of AAV Capsids

PDF | 2.0 MB
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Technical Note

Host Cell Protein Detection

PDF | 952.5 KB
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Technical Note

Anti-Penta HIS (HIS1K) Biosensors for Label-Free Analysis of HIS-Tagged Proteins

PDF | 1.5 MB
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Technical Note

Octet® Anti-Mouse IgG Fc Capture (AMC) Biosensors

PDF | 678.2 KB
Rapid Analysis of Fab Fragments and IgG with Anti-Human Fab2G Biosensors
Technical Note

Rapid Analysis of Fab Fragments and IgG with Anti-Human Fab2G Biosensors

PDF | 1.8 MB
Anti-HIS (HIS2) Biosensor Quantitation Assays technical note
Technical Note

Anti-HIS (HIS2) Biosensor Quantitation Assays

PDF | 630.9 KB
Octet® NTA Biosensor Quantitation Assays technical note
Technical Note

Octet® NTA Biosensor Quantitation Assays

PDF | 551.2 KB
Octet® NTA Biosensor Kinetic Assays technical note
Technical Note

Octet® NTA Biosensor Kinetic Assays

PDF | 589.8 KB
Octet® GST Biosensor Quantitation Assays
Technical Note

Octet® GST Biosensor Quantitation Assays

PDF | 600.2 KB
Octet® GST Biosensor Kinetics Assays technical note
Technical Note

Octet® GST Biosensor Kinetics Assays

PDF | 348.6 KB
Amine Reactive Second-Generation (AR2G) Biosensors
Technical Note

Amine Reactive Second-Generation (AR2G) Biosensors

PDF | 723.9 KB
Octet GlyM Kit Technical Note
Technical Note

Octet® GlyM Kit

PDF | 2.2 MB
Technical Note

Investigating Synthetic Immune Recruitment by Proximity Inducing Molecules: Validation of Covalent Immune Recruiter (CIRs) function using the Octet Platform

PDF | 1.3 MB
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Technical Note

Biotinylation of Proteins for Immobilization onto Streptavidin Biosensors

PDF | 515.3 KB
Residual Protein A Detection Kit
Technical Note

Residual Protein A Detection Kit

PDF | 1.8 MB
Technical Note

High Precision Streptavidin Biosensor (SAX) Quantitation and Kinetic Assays

PDF | 3.6 MB
Octet® Amine Reactive SecondGeneration (AR2G) Reagent Kit technical note
Technical Note

Octet® Amine Reactive Second-Generation (AR2G) Reagent Kit

PDF | 369.1 KB

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