Cellca Cell Line Technology License

High-performing platform for successful development

Sartorius offers a complete, plug-and-play solution for customers who develop cell lines and express proteins in their own facilities. The Cellca CLD Technology License is based on industry-leading Cellca Cell Line Development Technology using CHO DG44 host cells. It is ready to use and does not require further development or optimization, which means it delivers proven low risk and high timeline and performance success. We offer two packages: Research and Commercial, both of which are accompanied by substantial technical support throughout the technology transfer.

Simplicity

Package includes expression vector, host cell line, cell culture media, protocols, and bioprocess design for a complete out-of-the-box solution.

Reliability

Works with all types of protein products and Cellca’s track record ensures high probability of success.

Dependable Support

Fast troubleshooting and support from Cellca CHO experts

Ready-to-Use

Plug & Play into your facility with no further optimization or development needed

Ready for Researchers

Technology License for Research & Development

The Cellca CLD Technology License is for researchers interested in the stable expression of proteins in CHO DG44 cells, allowing generation of stable pools for in-house evaluation and R&D purposes. This ready-to-use solution increases the probability of success by delivering a mature, high-performing cell line to reduce timelines and financial investment. Plus, the license can easily be upgraded to a full commercial license.

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Attribute

Basic

Advanced

Host Cell*

6 Vials

6 Vials

4Cell® XtraCHO Media System*

Media for 3 CLD Projects

Media for 3 CLD Projects

Plasmid

3 vials for one- and 3 vials for two-chain molecules3 vials for one- and 3 vials for two-chain molecules

Gene Synthesis Protocol

 

 

Vector Cloning Protocol

 

 

Transfection, Pool Generation and Evaluation Protocol

 

 

Material Production in 1L Shake Flask Protocol

 

Fed-Batch Process in RM50 Protocol

 

Remote Client Support

 

 

On-side Client Support

 

Proof of Concept Study

 

* Additional material can be ordered as catalogue products.

The fully documented and tested according to ICH and WHO, CHO DG44 host cell line.

Cellca Expression vector systems are designed to optimize expression of the protein of interest and simplify selection of the right clone.

4Cell® XtraCHO Media System includes:

  • Stock and Adaptation Medium
  • Product Medium
  • Feed Medium A
  • Feed Medium B

Basic Offering

  • Provided by scientists in collaboration with Client Project Manager (CPM)
  • Remote customer support
  • 5 hours of remote standard support and 1 hour of "emergency" support

Advanced Offering

  • Additional 3 hours of standard support and 1 hour of "emergency" support
  • On-site support: 2 consecutive days

*Additional support can be purchased if needed.

  • Proof of Concept study focuses on one molecule of customer’s choice
  • Performed at our Cell Culture Technology Center in Ulm, Germany, in parallel to license run at customer’s site with the same molecule
  • The customer will receive relevant data packages + supernatants from selected cell culture runs
  • Trial term is available for clients who plan to purchase the technology license and would like to test the platform at their site
  • The duration of the license trial is one year.

*Other terms and conditions may apply

  • Personalized host cell line history report
  • TSE/BSE statement for plasmid
From Cell Line to Clinic

Easy-to-Use Commercial Technology License for Commercializing Your Protein

Create stable production cell lines expressing your protein of interest and take them to clinical trials and commercialization. This ready-to-use solution allows you to perform the CLD projects up to clone level and increases the probability of success by delivering a mature, high-performing cell line to reduce timelines and financial investment.

Get Started Today

Attribute

Basic

Advanced

Host Cell*

6 Vials

6 Vials

4Cell® XtraCHO Media System*

Media for 3 CLD Projects

Media for 3 CLD Projects

Plasmid

3 vials for one- and 3 vials for two-chain molecules3 vials for one- and 3 vials for two-chain molecules

Gene Synthesis Protocol

 

 

Vector Cloning Protocol

 

 

Transfection, Pool Generation and Evaluation Protocol

 

 

Clone Generation Protocol

 

 

Clone Evaluation with the Ambr15 Protocol

 

 

RCB Preparation Protocol

 

 

Material Production in 1L Shake Flask Protocol

 

Fed-Batch process in RM50 Protocol

 

Fed-Batch Process in Ambr® 250 Protocol

 

Stability Study Design Protocol

 

Remote Client Support

 

 

On-side Client Support

 

Proof of Concept Study

 

* Additional material can be ordered as catalogue products.

The fully documented and tested according to ICH and WHO, CHO DG44 host cell line.

Cellca Expression vector systems are designed to optimize expression of the protein of interest and simplify selection of the right clone.

4Cell® XtraCHO Media System includes:

  • Stock and Adaptation Medium
  • Product Medium
  • Feed Medium A
  • Feed Medium B

Basic Offering

  • Provided by scientists in collaboration with Client Project Manager (CPM)
  • Remote customer support
  • 8 hours of remote standard support and 2 hour of "emergency" support

Advanced Offering

  • Additional 4 hours of standard support and 1 hour of "emergency" support
  • On-site support: 4 consecutive days

*Additional support can be purchased if needed.

  • Proof of Concept study focuses on one molecule of customer’s choice
  • Performed at our Cell Culture Technology Center in Ulm, Germany, in parallel to license run at customer’s site with the same molecule
  • The customer will receive relevant data packages + supernatants from selected cell culture runs
  • Trial term is available for clients who plan to purchase the technology license and would like to test the platform at their site
  • The duration of the license trial is two years.

*Other terms and conditions may apply

  • Personalized host cell line history report
  • TSE/BSE statement for plasmid

Driven by Over 14 Years of Cell Line Development Expertise

The Cellca Cell Line Technology License is derived from Sartorius’ in-house service that delivers well-characterized and stable research clones. From DNA to research cell bank (RCB), the Cellca Cell Line Development Service delivers a fully characterized RCB in just 14 weeks with high protein titers of 3-8 g/L.

  • Well-characterized CHO DG44 host cell line with documented history
  • Process easily transferred and scaled up to a range of bioreactors up to 2000 L
  • Proven track record: more than 120 projects completed using the Cellca Cell Line Development service

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