mAb Molecule Development — Target Identification/Validation

Target Identification/Validation

Molecule development begins with target identification and validation. A new drug starts as an idea or hypothesis based on

  • Observations made during phenotypic drug discovery evaluations, or
  • Direct identification of targets with affinity during target-based drug discovery processes

Both these approaches require comprehensive understanding of the biological and molecular pathways underlying disease.

See how our Incucyte® Live-Cell Analysis and Intellicyt® iQue3 platforms can accelerate your mAb discovery workflow!

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NEW INFOGRAPHIC

Challenges and Solutions for Developing New Monoclonal Antibodies

Unprecedented advances in medicine are delivering remarkable results for some patients. Recent approvals of CAR T therapies and new approaches in regenerative medicine, for example, exemplify Monoclonal antibodies (mAbs) used for immunotherapy stimulate the immune system to mount a response to target antigens. These powerful therapeutics are being used to...

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WEBINAR

Accelerating Nanobody Discovery Workflows with High-Throughput Flow Cytometry

In this webinar, Dr. Pieter Kennis discusses how nanobodies – small, single-domain antibody fragments that retain full antigen-binding capabilities and the properties of heavy-chain antibodies – and nanobody discovery and screening platforms exploit high-throughput flow cytometry to increase the throughput of nanobody screening campaigns.

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Accelerate Your mAb Discovery Workflow

Incucyte® Live-Cell Analysis System

Don't miss crucial data by analyzing cells at pre-determined time points. Continuously interrogate dynamic changes in the same population of cells using imaged-based, real-time, live-cell analysis for relevant insight to cell- and treatment-specific responses – all from inside your incubator.

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iQue® Advanced Flow Cytometry Platform

Advance therapeutic antibody discovery with multiplexed screening. The iQue® 3 offers high content, multi-factorial, and actionable results for more insight and better decisions.

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NEW: Delve deeper into the biology of T Cell Exhaustion with our new Human T Cell Exhaustion Cell and Cytokine Profiling Kit.

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Resources

Brochure: Intellicyt® iQue3 Faster, Smarter Flow Cytometry

PDF | 6.0 MB

Application Note: Minimizing Syringe Filter Usage in Harvesting Monoclonal Antibodies from CHO Cell Culture Supernatants

PDF | 183.8 KB

Application Note: Vivaflow® 200: A Critical Sample Preparation Tool for Concentrating Hybridoma Supernatants

PDF | 680.9 KB

Application Note: Concentration of Mammalian Cell Culture Supernatants with Vivaspin® Turbo 15 and Amicon® Ultra-15 Devices

PDF | 138.5 KB

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