mAb Molecule Development Candidate Characterization

Monoclonal Antibody Candidate Characterization

Learn as much as possible about the structure and function of your lead candidates, and investigate changes that could impact patient safety.

Characterize your lead candidates with high-content, highly biologically relevant cell- and suspension-based assays from Sartorius.

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Challenges and Solutions for Developing New Monoclonal Antibodies

Unprecedented advances in medicine are delivering remarkable results for some patients. Recent approvals of CAR T therapies and new approaches in regenerative medicine, for example, exemplify Monoclonal antibodies (mAbs) used for immunotherapy stimulate the immune system to mount a response to target antigens. These powerful therapeutics are being used to...

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Intellicyt® iQue3

Rapidly identify and characterize candidates using our high-throughput, multiplexed system with fast and easy data visualization.

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IncuCyte® Live-Cell Analysis System

Fully characterize your lead antibody candidates on target cells via kinetic phenotypic and cell health assays. Visualize and analyze migration and invasion, proliferation and apoptosis over time using our fully integrated solution that includes cells, reagents and purpose-built software tools.

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Sartoclear® Dynamics Lab P15 and Lab V

Quickly and easily prepare your clarified supernatant with your target molecule with Sartoclear® Dynamics Lab, a simplified, small-scale, mammalian cell-harvest workflow for further analytics of your antibody lead candidates. 

Rapid and convenient clarification of high density mammalian cell cultures is often challenging. Our solution provides a single-step clarification and sterile filtration protocol--without clogging--that is 70% faster than traditional centrifugation.

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Lab Weighing Solutions for your Physico-chemical Analytical Tests

HPLC Sample Preparation/Preparation of Standards.

Semi-automatic preparation and documentation of highly reproducible HPLC calibration standards with the Cubis® MSA dosing system.

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Cubis II — Your Balance, Your Way

For analytical test method development and physico-chemical characterization of lead candidates, researchers need reliable weighing solutions that provide reproducibility and connectivity with other lab systems

Seamless Connectivity — Easy integration with lab software (directly connected to PC) and LIMS avoids the need for separate software islands. USB-C and optional Bluetooth connectivity is also available.

Boundless Configurations — Vast selection of capacity and readability options, draft shield types, weighing pans and displays – 60,000 possible configurations.

Full End-to-End Data Integrity — User management and LIMS connectivity ensure that the data acquired is reliable and will not be manipulated.

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BioOutsource Testing Services

Physiochemical and Structural Analyses

An essential requirement of therapeutic monoclonal antibody development is characterizing the inherent structural heterogeneity of the antibody. High- and low-molecular-weight species, charge variants, and post-translational modifications can all affect in vivo stability, loss of biological activity, and produce unwanted immune effects.

Our team of experienced chemists can provide the support and advice you need to ensure that protein structure analysis and physiochemical analysis is performed at appropriate stages during development of a therapeutic antibody so these risks are managed.
 
Biological Analysis

Characterize the binding and functional activity of your biologic molecule with a range of cell-based binding and potency assays. Advance the development of your monoclonal antibody with our comprehensive range of assay development and validation services, including pre-qualified assays for over 12 commercial monoclonal antibodies.

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Resources

Application Note:

From Mammalian Cell Cultures to Pure Proteins: Sartoclear Dynamics® Lab Significantly Reduces Cell Harvest Time

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Application Note:

Rapid Mammalian Cell Harvest without Centrifugation for Antibody Purification Using the Sartoclear Dynamics Lab Filtration System

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GEN Tutorial:

Simplified Small-Scale Harvest of CHO Cells for mAb Analytics

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Webinar:

Accelerating Nanobody Discovery Workflows with High-Throughput Flow Cytometry

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Brochure: Sartoclear Dynamics® Lab Convenient Mammalian Cell Culture Harvesting

PDF | 1.8 MB

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Application Note: Minimizing Syringe Filter Usage in harvesting Monoclonal Antibodies from CHO Cell Culture Supernatants

PDF | 204.5 KB

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Application Note: Vivaflow® 200: A Critical Sample Preparation Tool for Concentrating Hybridoma Supernatants

PDF | 680.9 KB

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Application Note: Concentration of Mammalian Cell Culture Supernatants with Vivaspin® Turbo 15 and Amicon® Ultra-15 Devices

PDF | 138.5 KB

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