High-Throughput and Modular Solutions for Protein Therapeutics Discovery & Development
Therapeutic proteins such as antibodies have recently emerged as not only successful immunotherapies but also as promising treatment options for infectious diseases like COVID-19. Among some already licensed monoclonal antibodies, several others are in clinical trials or in development to investigate whether they can effectively treat COVID-19 patients.
To mount a successful monoclonal antibody (mAb) as well as next-generation antibodies like nanobodies, bispecific antibodies and antibody fragments discovery and development program you need technologies that allow rapid identification and characterization of candidate molecules to identify those with superior target reactivity and to further optimize their functionality.
Our innovative solutions for discovery and development of mAb therapies streamline the workflow and increase productivity.
Accelerate your biotherapeutic development and still have peace of mind.
How we ensure confidence for your mAb discovery and development program:
Product Highlights for Protein Therapeutics Discovery & Development
Cell Analysis Platforms
Incucyte® Live-Cell Analysis System
Enables real-time, live-cell imaging and analysis directly inside your incubator. Measure kinetic effects of your antibody treatment on target cells without ever having to remove cells from the incubator.
iQue® Advanced Flow Cytometry Platform
High-throughput, suspension cell and bead analysis platform for rapidly profiling of cell phenotype and function in therapeutic antibody discovery workflows. Ideal for those screens where cells are precious or limited in number, the iQue3 is the fastest way to generate high-content data from small samples.
Octet® Label-Free Bio-Layer Interferometry (BLI) Detection Systems
Octet® systems are used for affinity ranking, epitope binning of small to large antibody matrices, Fc-receptor binding, cross-reactivity testing of other species, glycosylation screening, characterization of antibody-antigen binding kinetics and affinity, bispecific testing, and titer analysis for protein expression, all in one high throughput, easiest-to-use system.
mAb Purification Mini Platform
Sartorius’s mAb purification mini platform is ideal for small-scale purification of your mAb from up to 1 L of cell culture supernatant.
The mini platform includes up to seven steps to take you through all the workflows necessary for mAb purification: cell clarification and filtration, antibody capture by affinity chromatography, purification step(s), concentration, and sterile filtration.
Each of our application steps maximizes output for the next step in the workflow, to support a seamless mAb purification process with maximum output.