High-Throughput and Modular Solutions for Protein Therapeutics Discovery & Development

Therapeutic proteins such as antibodies have recently emerged as not only successful immunotherapies but also as promising treatment options for infectious diseases like COVID-19. Among some already licensed monoclonal antibodies, several others are in clinical trials or in development to investigate whether they can effectively treat COVID-19 patients.

To mount a successful monoclonal antibody (mAb) as well as next-generation antibodies like nanobodies, bispecific antibodies and antibody fragments discovery and development program you need technologies that allow rapid identification and characterization of candidate molecules to identify those with superior target reactivity and to further optimize their functionality. 

Our innovative solutions for discovery and development of mAb therapies streamline the workflow and increase productivity.

Accelerate your biotherapeutic development and still have peace of mind. 
 

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Product Highlights for Protein Therapeutics Discovery & Development 

Cell Analysis Platforms

Incucyte® Live-Cell Analysis System 

Enables real-time, live-cell imaging and analysis directly inside your incubator. Measure kinetic effects of your antibody treatment on target cells without ever having to remove cells from the incubator.

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iQue® Advanced Flow Cytometry Platform

High-throughput, suspension cell and bead analysis platform for rapidly profiling of cell phenotype and function in therapeutic antibody discovery workflows. Ideal for those screens where cells are precious or limited in number, the iQue3 is the fastest way to generate high-content data from small samples.

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Octet® Label-Free Bio-Layer Interferometry (BLI) Detection Systems

Octet® systems are used for affinity ranking, epitope binning of small to large antibody matrices, Fc-receptor binding, cross-reactivity testing of other species, glycosylation screening, characterization of antibody-antigen binding kinetics and affinity, bispecific testing, and titer analysis  for protein expression, all in one high throughput,  easiest-to-use system.

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Downstream Applications

mAb Purification Mini Platform

Sartorius’s mAb purification mini platform is ideal for small-scale purification of your mAb from up to 1 L of cell culture supernatant. 

The mini platform includes up to seven steps to take you through all the workflows necessary for mAb purification: cell clarification and filtration, antibody capture by affinity chromatography, purification step(s), concentration, and sterile filtration.

Each of our application steps maximizes output for the next step in the workflow, to support a seamless mAb purification process with maximum output.

Cell Line Development: A Perfect Fit, From Start to Finish

Cell line development with intelligent tools, services, and solutions for your unique needs.

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Umetrics® Suite for Advanced Data Analytics

Accelerate drug development by using Design of Experiment (DOE) to efficiently plan your experiments and analyze your results with MODDE®.

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View All Biologics Discovery and Development Resources

Webinar: Deeper insights into the mechanisms of immune cell killing of...

Advanced cell analysis tools are critical for unlocking the secret to immune cell interactions and enabling future breakthroughs in immune-based thera...

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eBook: Neutralizing Antibodies Making Mark in Next Wave of Biologics

Neutralizing antibodies will play a critical role in future vaccine and therapeutics development and have become a major focus for researchers.

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white paper cover

White Paper: Advanced Flow Cytometry and Live-Cell Analysis Give Rich...

Discover an advanced antibody screening method that focuses on speed and insight by using a novel reagent for characterizing ABI via both advanced flo...

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Importance of mAb Discovery and Development in Immunotherapy

A successful mAb-based discovery and development program begins with a comprehensive understanding of cancer cell biological and molecular pathways an...

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High-Throughput Antibody Discovery

Targeting Cell Surface Receptors for Signaling Blocking in Cancer

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DNA as Medicine: Encoding Cancer Therapeutic Antibodies

In this webinar, you will hear from two members of the clinical development and discovery research teams at Inovio, a biotechnology company that desig...

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Compendium - Accelerated Antibody Discovery

Monoclonal antibodies (mAbs) still remain a focus of biopharma research. In the discovery process, you need to make crucial decisions, such as selecti...

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Developing Next Generation Therapeutic Antibodies

Download now to learn about innovative solutions for rapid candidate characterization of that streamline and advance antibody therapeutic discovery.

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Challenges and Solutions for Developing New Monoclonal Antibodies

Monoclonal antibodies (mAbs) used for immunotherapy stimulate the immune system to mount a response to target antigens. These powerful therapeutics ar...

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eBook: How Are Label-Free Technologies Used in Early Drug Discovery?

How Are Label-Free Technologies Used in Early Drug Discovery?

Modern analytical techniques designed for real-time analysis and high-throughput capabilities significantly reduce the time to the discovery

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Application Note: Sterisart®

In this study, we evaluated the Sterisart® closed system sterility testing device, with a septum, for the recurrent sterile extraction of samples.

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Solutions for Biologics Drug Discovery with a focus on mAbs

Therapeutic antibodies have recently emerged as one of the most successful strategies for the treatment of both hematologic cancers and solid tumors.

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