End-To-End Cell and Gene Therapy Solutions

Cell therapy uses cells grown ex vivo as treatment. There are two main types — regenerative medicine, where cells or organs are produced for replacement, and gene-modified cell therapy (ex vivo gene therapy), where cells are modified to target disease. Gene therapy is designed to correct, suppress, or insert genes within cells to treat or prevent diseases like cancer and genetic disorders. In vivo gene therapy directly delivers the gene to the patient's body.

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Gene therapy can be used for in vivo treatment, where the treatment is injected directly into the patient. In ex vivo treatment, also known as gene-modified cell therapy, the cells are extracted, modified, and then reinjected into the patient. Cell therapy terminology is often used as gene-modified therapies, using cells for treatment. Cells like stem cells and induced pluripotent stem cells can be used for this purpose, as well as for regenerative medicine.
 

Scientists prefer single-use equipment to mitigate the risk of cross-contamination as well as contamination from viruses and bacteria. In cell therapy, scientists don't perform filtration or chromatography because the cells are the final product. However, a bioreactor and centrifuge are needed to separate, clean, and wash the cells. If you're using a viral vector for gene therapy, you'll also need a bioreactor, along with a complete downstream process including standard filtration, tangential flow filtration, and chromatography.