TFF Cassettes

Efficient filtration is a critical step in biopharmaceutical processing. Sartorius tangential flow filtration (TFF) cassettes provide high-performance separation in various upstream and downstream bioprocessing unit operations. They are available in a range of molecular weight cut-offs and micron range, from lab scale to process scale, in single-use and re-usable formats. When used together with associated TFF systems and filter holders, these TFF cassettes provide a complete seamless solution for efficient, robust, and reproducible TFF operations, including ultra- and microfiltration.

Find the Right Tangential Flow Filtration Cassette

For the retention of materials in the ultra-scale range (e.g., proteins, mAbs, or viral particles)

Attribute

Hydrosart® Ultrafilter

Polyethersulfone (PES) Ultrafilter

Nominal Molecular Weight Cut-offs

2, 5, 10, 30, 100, 300 kDa

1, 5, 8, 10, 30, 50, 100, 300 kDa

Filtration Areas

10 cm², 50 cm², 200 cm², 0.1 m², 0.4 m², 0.6 m², 0.7 m², 1.4 m², 3.0 m², 3.5 m², 7 m², 14 m²

10 cm², 50 cm², 200 cm², 0.1 m², 0.4 m², 0.6 m², 0.7 m², 1.4 m², 3.0 m², 3.5 m²

Typical Process Fit

Peptide, Oligonucleotide, Proteins (Albumin), Blood Factors, Monoclonal antibodies (mAb), Vaccines

Proteins (Albumin), Blood Factors, Monoclonal antibodies (mAb), Vaccines

Self-contained

Available

Partially Available

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For the retention of material on the micro-scale range (e.g., cells and visible particles)

Attribute

Hydrosart® Microfilter

Polyethersulfone (PES) Microfilter

Pore Size

0.2 & 0.45 µm

0.1 µm

Membrane Areas 

200 cm², 0.1 m², 0.4 m², 0.6 m²,  3.0 m²

200 cm², 0.1 m², 0.6 m²,  3.0 m²

Typical Process Fit

Cells, Particles

Cells, Particles, Mycoplasma reduction

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Advantages of Single-Use TFF Cassettes

  • Pre-flushed, sterile, ready to use.
  • No cleaning or water flush required, which saves time on setup and validation.
  • High product yield and high sustained flux due to low-protein-binding membrane.
  • No glues used, resulting in low extractables

Hydrosart® Ultrafilter

Hydrosart® high-performance membrane is a stabilized cellulose-based membrane that has been optimized for biopharmaceutical process applications.

  • Stable across a broad pH range.
  • Extremely hydrophilic, making it non-protein binding and virtually non-fouling.
  • Membrane cleaning, storage and depyrogenation can be accomplished by using NaOH even at elevated temperatures and concentrations.

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Polyethersulfone Ultrafilter

The polyethersulfone (PES) membrane is well-established in the biotechnological and pharmaceutical industries.

  • Stable polymer that features a broad pH and temperature range.
  • Membrane regeneration, storage and depyrogenation can be accomplished by using NaOH even at elevated temperatures.
  • Ideally suited for biotechnology applications

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Single-Use Sartocube Hydrosart® Self-Contained Unit

Sartocube® Self Contained Units (SCUs) are 1.4 m² to 14 m² pre-sterilized disposable units suitable for use in cGMP environments. The SCU is available in a variety of molecular weight cut-offs and in polyethersulfone (PES) and Hydrosart® membrane types.

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Related Products

Sartocon® TFF Flat Sheet Cassettes

High-performance separation in various upstream and downstream bioprocessing unit operations.

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Clean-In-Place (CIP) Flush Cassettes

CIP flushing cassettes are ideal for sanitizing many filter holders. On-the-spot cleaning saves process and validation time.

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Learn More About TFF Cassettes

Related Assets

Datasheet

Sartocube Self-Contained Unit

PDF | 325.8 KB

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