OnDemand Inside the Development of an AAV8 Production Platform

On-Demand Webinar | Inside the Development of an AAV8 Production Platform Designed for Scale

Adeno-associated virus (AAV) vectors are pivotal in gene therapy, yet their production faces significant challenges, including scalability, low recovery rates, and the need for effective separation of empty and full capsids. This study presents a comprehensive AAV8 production platform developed together with CDMO Matica Biotechnology, and addresses industry pain points through innovative upstream and downstream processes.

By leveraging scalable bioreactor systems up to the 50L Biostat STR^® bioreactor, we meticulously optimized the upstream process. The downstream process incorporated advanced filtration and chromatography techniques to enhance virus recovery and purity.

The combination of data analytics and screening tools enabled us to optimize process parameters in small scale, and we effectively translated the results to the 50L scale. The established platform offers a flexible solution for high-yield AAV production demands.

What You Will Learn:

Explore AAV8 production challenges and solutions
Learn techniques to optimize upstream and downstream AAV8 production
Understand how to apply data analytics for process optimization

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Franziska Bollman

Program Manager Application & Testing, Separation Technologies

Dr. Franziska Bollmann, PMP^®, is a Program Manager in Separation Technologies at Sartorius, where she manages partnerships for multiple modalities including AAV.

She has years of experience focusing on developing viral vector production processes for gene therapy applications. She is also an experienced project manager, leading global project teams in the biotech industry for more than 10 years.

Denis Odokonyero

Downstream Process Development Scientist III, Matica Biotechnology

Denis Odokonyero is a Downstream Process Development Scientist at Matica Biotechnology, bringing expertise honed through years in the biopharmaceutical field. He earned his graduate degree from Texas A&M University, delving into molecular microbiology, biochemistry and biophysics before transitioning to industry.

Specializing in purification and analysis, Denis has worked extensively with diverse biopharmaceuticals, including virus-like particles, monoclonal antibodies and their derivatives, recombinant proteins, enzymes, peptides, hormones, and viral vectors for cell and gene therapies. His skill set bridges cutting-edge science with practical application.