​​Biowelder® S Automated Aseptic Welder for PVC & TPE Tubing​ 

Biowelder® S: Automated Aseptic Welding for PVC & TPE Tubing

Streamline CGT processes with safer and less labor-intensive handling

Biowelder® S was developed to support cell and gene therapy (CGT) product development along with good manufacturing practice requirements. It enables fast, sterile connection of small polyvinyl chloride (PVC) and thermoplastic elastomer (TPE) tubing in a non-classified environment as well as Grade B and C clean rooms — helping you keep running costs low while supporting paperless GMP manufacturing.

Unmatched flexibility: One size fits all  
  • Welds dry, wet, & liquid-filled tubing out-of-the-box
  • Universal parameters, no need for accessories
Fit for welding in cell & gene therapy
  • Supports most sizes & materials 
  • Electronic recording to support 21 CFR part 11 | EU GMP Annex 1   
Complete welding cycle in 30 seconds
  • Turns on in one minute, welds in 30 seconds
  • Completes cycle even if external power supply fails

Biowelder® S for Cell and Gene Therapies 

Out of the box, Biowelder® S supports most tubing sizes and materials used for cell and gene therapy bioprocessing from cell sourcing to cryopreservation. You can use it to streamline your aseptic tube connections at high speed and low cost in your perfusion process — as well as throughout bioprocessing in cell and gene therapy.

GMP-Compliant Aseptic Welding for PVC and TPE Tubing

While traditional welders use a horizontal movement that restricts support to one tubing size per holder, Biowelder® S uses a vertical movement to cover three different tubing sizes without the need for interchanging holders.

The Biowelder® S Cartridge includes up to 50 stainless steel blades with a high level of uniformity designed to optimize heat distribution during cutting and welding.

The device is automated and easy to use with a five-inch touchscreen, which visually guides operators through the process.

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Biowelder® S Automated Aseptic Welding Device 

Automation & intuitive operation 

Fully automated welding process with visual guidance displayed on five-inch touchscreen. 

Flexibility

Validated for common tubing including Saint-Gobain Tygon® ND 100-65 and C-Flex® 374, Tuflux® TPE, and MED 6536 from RAUMEDIC. Validation guide available for quality assurance. 

Short welding time 

Produces fast, reliable, and automated connections in 30 seconds. 


Designed for Fast, Flexible, Automated Welding 

Biowelder® S is designed to meet the need for aseptic thermal welding in CGT and GMP manufacturing. You can use it to aseptically connect two tubes made of PVC or TPE. At the end of the operation, the device will provide one welded tube and discard two leftover ends.

Streamline Your Processes in Cell and Gene Therapy

Enhance Your CGT Workflow With a One-Size-Fits-All Welder

Traditionally, most cell and gene therapy welders were developed for blood transfusion or biopharmaceutical applications. But they come with limitations — they either don’t support all sizes, or they don’t work with both PVC and TPE, forcing users to purchase multiple devices for a single application. This is not only more costly in terms of upfront investment and maintenance, but also in terms of space, as more equipment increases your workflow’s footprint in your lab or manufacturing area. 

By covering PVC and TPE in all relevant sizes for cell and gene therapy, Biowelder® S is designed to streamline your aseptic connections from cell sourcing to cryopreservation. 

Biowelder® S | Comprehensive Welding in One Device 

Biowelder® S is designed to enable aseptic thermal welding for GMP and CGT manufacturing. The device is automated and easy to use with a five-inch touchscreen that visually guides operators through welding. Weld logs and audit trails are simple to export using USB or ethernet, enabling paperless and easy documentation. 

Biowelder® S Components, Accessories, and Services

Maximize performance and ensure uninterrupted operation with single-use components, accessories, and service from Sartorius.

Biowelder® S Cartridge

The welder has only one consumable — the Biowelder® S Cartridge — and discards blades after each weld to ensure sterility.

Tray Inserts

Enhance flexibility with additional tray inserts, allowing you to easily transport multiple bags to the welder.

Optimize Instrument Performance

Maximize longevity and minimize downtime of your research and biomanufacturing equipment with service from Sartorius.

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Frequently Asked Questions

Sterile tube welding connects tubes in classified or non-classified environments. Biowelder® S uses a clean, hot blade for cutting and welding to ensure integrity.

Key factors are sterility validation, weld quality, material compatibility, ease of use, and industry compliance. Biowelder® S ensures aseptic, reliable welds with proven bacterial challenge testing.

Yes. Biowelder® S can weld PVC to PVC tubing and TPE to TPE tubing in three different sizes.

A welder should support PVC for medical applications like cell sourcing and TPE for bioprocessing — as well as reliability, ease of use, and support for regulatory compliance.

An aseptic connector uses a sterile interface to create a connection while minimizing contamination. It leverages self-sealing to maintain sterility in non-sterile environments.

Consult Our Experts

Consult Our Experts

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