Octet® BLI Label-Free Detection Systems for Biomolecular Interactions Analysis

Unprecedented Time and Cost Savings For Kinetics, Affinity, and Concentration Assays

Based on Bio-Layer Interferometry (BLI), Octet® BLI systems enable real-time, label-free analysis for the determination of kinetics, affinity and antibody/protein quantitation. This fluidics-free instrument platform offers several advantages over other label-free techniques like Surface Plasmon Resonance (SPR).

The Octet® BLI platform also provides robust monitoring of biomolecular interactions to overcome limitations in throughput, performance and cost associated with traditional technologies such as enzyme-linked immunosorbent assay (ELISA) or high-performance liquid chromatography (HPLC). These fluidics-free, low-maintenance, sensitive systems increase lab productivity, reduce costs and shorten experimental timelines.  

  • Higher Throughput - Protein quantitation in as little as two minutes, and parallel processing of up to 96 samples 
  • Fast Time to Results – Automated analysis for faster time-to-market and faster publications
  • Real-time Analysis – Binding interactions are continuously monitored as they happen. Don’t miss out on subtle kinetic behavior patterns.
  • Crude Sample Compatibility - Analytes can be measured in crude, unpurified mixtures such as cell lysates or hybridoma supernatants.
  • Ease of Use – Simple, integrated user interface designed for biologists. Spend less time learning instrumentation and more time deriving insights.
  • Low Total Cost of Ownership – Low-maintenance system has no fluidics modules to clog, so no downtime while waiting for replacements.

Why Choose Genuine Octet® BLI?

Find Out How You Can Leverage the Power of Octet®️

Boost your research and commercialization goals by combining BLI and SPR at an attractive promotional price. 

Explore Promotion

Octet® R Series

Accelerate Your Research with an Upgradeable, Label-Free Protein Analysis Platform

The Octet® BLI is an easy-to use, real-time analytical tool that rapidly screens critical quality attributes.

2-Channel System: Octet® R2

Grows With Your Biomolecule Characterization Needs

Explore Octet® R2
Octet R4 label free detection system

4-Channel System: Octet® R4

The Perfect Balance Between Cost and Throughput with Given Leeway

Explore Octet® R4
Octet R8 label free detection system instrument

8-Channel System: Octet® R8

Unmatched Flexibility and Versatility in Protein Analysis

Explore Octet® R8

Octet® RH16 and RH96

Unprecedented Throughput for Industry Applications

Octet® BLI rapidly determines recombinant protein concentration as a control parameter in cell line development.

96-Channel Ultra High Throughput Octet System: Octet® RH96

Monitors up to 96 biosensors simultaneously, enabling label-free detection for protein quantitation and kinetic characterization at unmatched speed

Explore Octet® RH96
Octet RH16 ultra high throughput label free detection system

16-Channel High Throughput Octet System: Octet® RH16

Ideal for high-throughput applications that demand high sensitivity and low sample volume requirements

Explore Octet® RH16

Octet®️ N1 – Label-Free Assays in a Drop

Octet N1 label free detection system

Octet® N1

Label-free assays in a drop

Explore Octet® N1

Octet® BLI Systems in Action

See How the Octet® Bio-Layer Interferometry Systems Are Evolving

The Sartorius Octet® BLI platform has become an invaluable technique analyzing therapeutic biomolecules at various stages of development. 

With unparalleled ease-of-use, the instruments transform workflows beyond the limitations of label-free methods, providing comprehensive characterization capabilities across a broad range of applications critical for efficient biotherapeutics development and production. 

Explore the Fluidic-Free Industry Standard for Label-Free Analysis

Whether your lab is just getting started or requires higher throughput for screenings or analyzing large numbers of samples, the Octet® R series has a range of price points and throughput capabilities to help you simplify progress. 

Discover the Octet® R Series

Discover Octet® Solutions for Your Application

With a wide range of ligand capture surfaces that allow for immobilization of antibodies, recombinant proteins, DNA, RNA and virus-like particles, the Octet® BLI platform has become a must-have laboratory tool for biomolecular interactions studies. 

Benefit for Label-Free Detection Requirements

Lab technician with Octet RH96 ultra high throughput label free detection system
Experimental Simplicity to De-Risk Your Journey and Simplify Progress

A microfluidic-free design allows for unprecedented time and cost savings for binding kinetics, affinity and analyte concentration measurement with high precision, accuracy and a broad dynamic range.

Analyze Tough Samples Faster 

Parallel processing of up to 96 samples - coupled with minimal sample preparation - provides unprecedented throughput. Use fluidics-free assays with 96- and/or 384-well sample plates and ready-to-use biosensors for flexibility in sample types from large biologics to small molecules, purified or in crude form.

Perfect for Multi-User Environments 

Octet® BLI systems are known for reliable, user-friendly, trouble-free operation and have quickly become the go-to systems in academic and industrial labs for their ease-of-use, robustness and application flexibility.

Transfer Methods to QC and Manufacturing with Confidence

Rapidly develop and validate Octet® BLI assays for lot release, ligand binding, quantitation and impurity assays.

Why Do Researchers Choose Genuine Octet® BLI?

Thousands of researchers trust Octet® BLI systems for superior
performance, confident compliance, and exceptional customer
service & support.

  • 7000+ Octet® BLI publications
  • 3,500+ instrument installs worldwide
  • Much, much more

See Why Researchers Choose Octet® BLI

Request a Quote, Demo or More Info

Educational Resources

7000+ Octet publications New

Octet® Publication Database

Literature references covering a large variety of research areas and applications

Search Featured Publications
Octet R Series System brochure cover

Octet® R Series Systems

Accelerate your research with an upgradeable, label-free protein analysis platform

Access Brochure
app note cover
Application Note

Biomolecular Binding Kinetics Assays on the Octet® Platform

Introducing label-free platforms, the technology, capabilities, and advantages of label-free binding assessment

Access Application Note
Case Study

Bispecific Antibodies: From Research to Clinical Application

Learn how Octet BLI transforms our approach to drug discovery and development

Read Case Studies

Comparability Studies: Minimize Time, Maintain Quality

Developing Methods for Comparability Studies of Therapeutic Monoclonal Antibodies

Access Webinar
A compendium for successful BLI and SPR assays
Application Guide

A Compendium for Successful BLI and SPR Assays

Octet® Label-Free Biosensor Analysis

Access the Guide
Octet Kinetics Assay Method Development Guideline thumbnail
Technical Note

Octet® Kinetics Assay Method Development Guideline

Developing kinetics binding assays to establish specificity, accuracy, precision, linearity and range as stipulated by USP 1032

Access Technical Note
app note thumbnail
Application Guide

A Simple Method to Determine Relative Potency (EC50)

Using Octet® BLI Technology

Access Guide
Analysis of Fc-Gamma Receptor-IgG Interactions on the Octet® Platform
Application Note

Analysis of Fc Gamma Receptor IgG Interactions on Octet® Platform

Whether you're assessing FcRn-Antibody or FcγR-IgG binding interactions, you need a high throughput, versatile, and easy to use solution.

Access Application Note

Product Resources

Octet top 10 reasons to choose BLI

Top Ten Reasons to Choose Sartorius Octet®️ BLI Technology to Accelerate Your Research, Development, and Manufacturing

PDF | 167.1 KB
Octet® Systems in Bioprocessing: Easy-to-Use and Cost-Effective Tools for Multiple Applications
Application Guide

Octet® Systems in Bioprocessing: Easy-to-Use and Cost-Effective Tools for Multiple Applications

PDF | 282.5 KB

Request a Quote, Demo, or More Information

What other areas are you interested in? (select all that apply)

Request a Quote, Demo, or More Information

Related Content


Applications for Label-Free Detection

Explore More

Octet® System Service and Support

Explore More

Octet® BLI Resources

Explore More

Follow Octet® on LinkedIn

Get the Latest Updates, Trends and Developments on Label-free, Stress-Free Solutions for Drug Discovery, Biologics Development and Biomanufacturing.

Follow Us Now