Data Acquisition & Analysis, Simplified
Centralized, Compliant, and Built for Collaboration
Octet® systems combine high-performance biolayer interferometry (BLI) with intuitive software for rapid kinetic analysis, quantitation, and epitope characterization. With Octet® Software Version 14, labs can now use Octet® Hub to centralize methods, projects, and results in a single governed workspace, helping teams move faster while maintaining data integrity.
Product Manager Octet® | Sartorius
Stop managing work across scattered folders, shared drives, and email copies—Octet® Hub keeps your team aligned on a single project context.
What’s New in Octet® Software Version 14?
Octet® Software Version 14 introduces Octet® Hub – a centralized database for Octet® projects and assets. Octet® Hub brings together methods, experiments, analysis settings, and results in one secure workspace helps scientists spend less time managing data and more time advancing their work.
Key features
- Hub-based data management - Centralize methods, experiments, analyses, and results in one trusted source of truth.
- Project-based organization - Structure work by lab, team, program, or customer project for clearer ownership and collaboration.
- Version history - Track changes to methods and analysis settings and revert when needed to support reproducibility.
- Collaboration with control - Share within projects without creating uncontrolled copies; built-in protections help prevent simultaneous-editing conflicts.
- User groups and role-based access - Ensure the right people have the right level of access across projects and instruments.
- Backup and restore - Admin-friendly workflows to protect valuable data and simplify recovery.
Two Suites. All Requirements Covered.
Octet® Research Suite with Research Hub - Fast, Flexible Discovery Without the Overhead
The Research Suite is designed for high‑velocity discovery labs that need to move quickly from idea to insight. It offers intuitive, streamlined data acquisition and analysis, allowing scientists to build, run, and compare methods and experiments in a central hub—without heavy governance slowing them down. Teams can organize projects clearly, share results easily, and maintain version history for reproducibility, all while benefiting from the speed and flexibility needed in early‑stage research.
What you gain
- A centralized home for methods and results – no more scattered folders
- Searchable projects and assets for faster method and data reuse
- Version history to support reproducibility
- Simple sharing across teams without duplicate copies
- Identity integration options (e.g., Active Directory / SSO, where enabled)
- Backup and restore tools to help protect valuable work
Octet® Compliance Suite with Compliance Hub: Governance, Traceability, and 21 CFR Part 11 Readiness
The Compliance Suite is built for regulated environments that require robust control, auditability, and data integrity. It layers role based access, centralized method and results management, full version tracking, and audit ready reporting on top of Octet® Hub’s core capabilities. With features aligned to 21 CFR Part 11 expectations, the Compliance Suite helps organizations standardize workflows, enforce permissions, and demonstrate control over biomolecular interaction data throughout its lifecycle.
Additional capabilities include
- Role-based access and project-level permissions to control who can do what
- End-to-end workflow traceability from method to experiment to analysis and instrument
- Audit-ready reporting, including user activity, access, and role reports
- Identity integration options (e.g., Active Directory / SSO, where enabled)
- Session management and configurable security policies to help protect sensitive work
- Ability to create custom roles (Compliance Suite) for tailored governance needs
Flexible Deployment for Different Lab Environments
Option 1 – Shared Octet® Hub on an IT managed server (recommended)
- One Hub for a lab or organization
- Users and instruments connect to shared projects
- Supports centralized administration, backup, and security practices
- Ideal for multi-user teams and regulated environments
Option 2 – Local Hub on a workstation
- Hub installed on a designated “host” workstation
- Enables small teams or pilot deployments to benefit from project-based organization and shared access
- Minimal infrastructure overhead – suitable where IT resources are limited
Benefits of Octet® Analysis Studio
Octet® Analysis Studio is fully supported within Octet® Software Version 14 and integrates with Octet® Hub for centralized storage and reuse of analysis methods and results.
A new assay can be set up in just a few minutes. To make assay setup even faster, experimental method templates are available. Analysis settings can be saved and applied to new assays to speed up routine analysis.
Octet® CFR Software and our Octet® GxP Server enable data acquisition and data analysis in laboratories working under GMP, GLP and 21 CFR Part 11 regulations. They also provide necessary technical administrative features for compliance with FDA regulations. Controlled access with multiple user levels and a set of permission structure are available: administrator, developer, supervisor, lab user.
Create customized reports for experiments, combining various data elements such as graphs, text, data tables, company logo, images and experimental details. Reports are ready to be uploaded to an electronic notebook or stored in the database. Report templates can be saved and reloaded to make similar reports for additional datasets.
Applications
Kinetics and Affinity Analysis
Octet® Analysis Studio allows for fast and convenient analysis of assays measuring kinetics and affinity values for drug-target binding and high-throughput kinetic screening for lead identification. Typical applications include kinetic analysis of protein-protein, protein-small molecules, antibody-antigen, antibody-VLP, antibody-Fc gamma receptors, including antibody-neonatal receptor (FcRn) interactions. Additional applications supported include lot release and stability analysis of drug molecules based on binding kinetics and affinity.
- Combine and analyze multiple experiments spanning different days, runs, and replicates
- Allows for flexible sample referencing and biosensor subtraction schemes
- Advanced data processing options for eliminating bulk shifts or assay artifacts from kinetic datasets
- Improved 1:1, 1:2, 2:1 and mass transport curve fitting algorithms along with Local and Global data fitting options
- Create customized data reports and export to Microsoft® Excel® and PDF
Concentration Analysis
Octet® BLI assays are widely used for concentration or titer analysis of various biomolecules including IgG, Fab, custom proteins, and viruses. Additional quantification applications supported include host cell protein (HCP), residual protein A, pharmacokinetic (PK) assays, and antibody isotyping analysis.
- Combine multiple experiments and analyze data using a single analysis template
- Allows for flexible reference subtraction schemes to incorporate and utilize data from control samples easily
- 4PL, 5PL with unweighted and weighted fitting algorithms for concentration analysis
- Ability to view and analyze any step(s) in a multi-step quantitation assay.
- Automated sample alert tools to evaluate data quality for precision, accuracy, and dilution linearity, enabling you to confidently interpret results.
- Import previously prepared standard curves for routine assays
- Customize and export final reports in Microsoft® Excel® and PDF formats.
Potency Analysis
Drug activity or potency can be measured via an Octet® BLI binding assay. Unlike in ELISA or other endpoint detection technologies, when performing potency assays on an Octet® system, every step of the assay can be monitored in real-time, leading to faster assay development. Automated assay workflows also reduce hands-on times while improving assay precision and reproducibility. Octet® Software versions 13.x and above provide potency analysis tools.
- Conveniently setup EC50 and IC50 experiments with built‑in experimental method templates in Octet® Discovery Software
- 3PL, 4PL, 5PL, linear, and semi-log fitting algorithms
- Monitor biosensor loading responses and flag data traces based on user-defined biosensor loading criteria
- Independent and global dose-response fitting options and similarity assessments to effectively compare against standard and test sample groups
- Create customized data reports for presenting and reporting dose-response data and conclusions
- Eliminate errors in data transfer with a built-in potency analysis module, available in both CFR 21 part 11 and non-CFR software versions
Epitope Binning Assays - Advanced Analysis with Octet® Analysis Studio
Octet® BLI systems are ideally suited to run cross-competition assays, due to the combination of assay speed, the versatility of assay design with the ability to perform in-tandem, sandwich as pre-mix assays, and the use of parallel, independent biosensor formats. Octet® Analysis Studio software provides a dedicated module for convenient epitope binning analysis.
- Append and overlay data from multiple experiments, plates, or biosensor trays to create a combined dataset for advanced analyses
- Software automatically finds and annotates the binning cycle pattern and creates a 2D traffic-light matrix and BinChart for displaying antibody clusters
- Cluster antibodies in similar bins or groups based on Euclidean, Pearson, and Maximum algorithms
- Additional matrix analyses such as normalizing to controls or self-binding and highlighting unidirectional binning pairs can be performed
- Simple data quality assessment can be accomplished by monitoring loading levels and flagging antibodies with high off-rates
Quick Start Guides
Server Computer Requirements – Octet® Hub
| Item | Minimum | Recommended |
|---|---|---|
| Operating system | Windows Server 2019, 2022 or 2025 | Windows Server 2025 |
| Processor | Dedicated 4 cores | Dedicated 4 cores |
| Memory | 8 GB | 16 GB |
| Storage | 250 GB | 512 GB |
| Network | Customer network with 100 Mbps required dependent on the deployment scenario | |
| Backup | Customer-managed | Standard IT backup policy |
| Time synchronization | Required for Compliance | NTP/domain time source recommended |
| Identity integration | Domin joined server for Active Directory/SSO login |
Client Workstation Requirements
| Item | Minimum | Recommended |
|---|---|---|
| Operating system | Windows 10 64-bit Professional/ Enterprise or Windows 11 | Windows 11 |
| Processor | Dedicated 2 cores | Dedicated 4 cores |
| Memory | 4 GB | 16 GB |
| Display | 1920 X 1080 | 1920 X 1080 |
| Network connection | Required for Octet® Hub access | Stable LAN/VPN connection with 100 Mbps or higher |
| Addional Software | Microsoft® Excel |
Octet® Instrument Controller Requirements
| Item | Requirement |
|---|---|
| Operating system | Windows 10 Professional/ Enterprise or Windows 11 |
| Processor | Dedicated 4 cores |
| Memory | 16 GB |
| Storage | 512 GB |
| Instrument connection | USB 3.0/RS-232 |
| Display | 1920 X 1080 or better |
| Network | Required for Octet® Hub access |
| Laptop use | Not recommended |
Featured Resources
A Simple Method to Determine Relative Potency (EC50) Using Octet® BLI Technology
PDF | 1.1 MB
