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Bio-Layer Interferometry is an analytical technique that monitors the interference pattern of white light reflected from two surfaces; a layer of immobilized protein on the biosensor tip and an internal reference layer.

The binding of an analyte in solution to the immobilized protein (ligand) on the biosensor results in an increase in optical thickness which in turn causes a shift in the interference pattern resulting in a wavelength shift. This shift in wavelengths (nm) is reported in real time. Only molecules that associate or dissociate and cause a change in optical thickness elicit a response pushing the boundaries of label-free biomolecular interaction analysis (BIA) in terms of scalable throughput, flexibility, and sample compatibility.

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Octet® BLI Label-Free Detection System instruments

Octet® BLI Systems

Enable real-time, label-free analysis for the determination of kinetics, affinity and antibody/protein quantitation.

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Biosensors & Kits

Available in a wide range of surface chemistries for use in a diverse set of biomolecular applications.

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GxP Compliance Tools

A wide range of compliance tools for developing validated assay methods on the Octet® BLI platform.

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Octet® Systems Software

Facilitate data acquisition and data analysis in laboratories working under GMP, GLP and 21 CFR Part 11 regulations.

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Educational Resources

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Literature references covering a large variety of research areas and applications

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A compendium for successful BLI and SPR assays
Application Guide

A Compendium for Successful BLI and SPR Assays

Octet® Label-Free Biosensor Analysis

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Application Note

Biomolecular Binding Kinetics Assays on the Octet® Platform

Introducing label-free platforms, the technology, capabilities, and advantages of label-free binding assessment

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Technical Note

Octet® Kinetics Assay Method Development Guideline

Developing kinetics binding assays to establish specificity, accuracy, precision, linearity and range as stipulated by USP 1032

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Application Guide

A Simple Method to Determine Relative Potency (EC50)

Using Octet® BLI Technology

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Analysis of Fc-Gamma Receptor-IgG Interactions on the Octet® Platform
Application Note

Analysis of Fc Gamma Receptor IgG Interactions on Octet® Platform

Whether you're assessing FcRn-Antibody or FcγR-IgG binding interactions, you need a high throughput, versatile, and easy to use solution.

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Case Study

Bispecific Antibodies: From Research to Clinical Application

Learn how Octet BLI transforms our approach to drug discovery and development

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