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Bio-Layer Interferometry is an analytical technique that monitors the interference pattern of white light reflected from two surfaces; a layer of immobilized protein on the biosensor tip and an internal reference layer.

The binding of an analyte in solution to the immobilized protein (ligand) on the biosensor results in an increase in optical thickness which in turn causes a shift in the interference pattern resulting in a wavelength shift. This shift in wavelengths (nm) is reported in real time. Only molecules that associate or dissociate and cause a change in optical thickness elicit a response pushing the boundaries of label-free biomolecular interaction analysis (BIA) in terms of scalable throughput, flexibility, and sample compatibility.

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Sartorius Solutions for BLI Detection

Octet BLI systems

Octet® BLI Systems

Enable real-time, label-free analysis for the determination of kinetics, affinity and antibody/protein quantitation.

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Octet biosensors

Biosensors & Kits

Available in a wide range of surface chemistries for use in a diverse set of biomolecular applications.

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GxP Compliance

GxP Compliance Tools

A wide range of compliance tools for developing validated assay methods on the Octet® BLI platform.

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Lab technicians with Octet RH96

Octet® Systems Software

Facilitate data acquisition and data analysis in laboratories working under GMP, GLP and 21 CFR Part 11 regulations.

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Featured Resources

A compendium for successful BLI and SPR assays
Application Guide

A Compendium for Successful BLI and SPR Assays

Octet® Label-Free Biosensor Analysis

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Application Note

Biomolecular Binding Kinetics Assays on the Octet® Platform

Introducing label-free platforms, the technology, capabilities, and advantages of label-free binding assessment

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Technical Note

Octet® Kinetics Assay Method Development Guideline

Developing kinetics binding assays to establish specificity, accuracy, precision, linearity and range as stipulated by USP 1032

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