Biologics Characterization Tools

Industry Standards for Screening, Characterizing Biomolecular Interactions (Including Antibodies)

The Octet® platform is a comprehensive solution for screening and characterizing molecular interactions such as protein-protein or protein-drug, enabling an enviable variety of applications throughout biologics development from early selection to validation to manufacturing.

Our instruments utilize industry-leading, label-free technologies - Bio-Layer Interferometry (BLI) and Surface Plasmon Resonance (SPR). Both are deemed appropriate for bioanalysis within chapters of the United States Pharmacopeia (USP).

The Octet® family of instruments has been an industry standard for label-free analysis across biologics development and manufacturing for more than 15 years.

Request an Octet® Quote or Demo

Find Out How You Can Leverage the Power of Octet®️

Boost your research and commercialization goals by combining BLI and SPR at an attractive promotional price. 

Explore Promotion

Discover the Octet® SF3 SPR platform

Sartorius Solutions for Biologics Characterization

Scientists with the Octet RH96

Octet® Label-Free BLI Detection Systems

Ideal for titer and concentration analysis as well as screening for CQAs early in cell line development and bioprocess development workflows

Explore BLI Detection
Octet SF3 SPR System

Octet® SPR Detection

Generate the most accurate data possible in the shortest timeframe imaginable. Simplifies kinetic characterizations and fragment screens.

Explore SPR Detection

Why Choose Sartorius for Label-free Biomolecular Interaction Analysis? 

Continuous Innovation

As a trusted scientific partner, we deliver unique solutions to research challenges. Our goal is to provide best-in-class products for real-time analysis of biomolecular interactions in micro-volume sample sizes, providing information on affinity, kinetics and concentration.

Extensive Publication Success

Label-free systems from Sartorius have become indispensable tools in academic and biopharmaceutical research, from characterizing binding interactions and specificity to engineering proteins and antibodies. We have more than 5000 publications on the use of Octet® products within various applications.

World Class Service

Our comprehensive service plans include validation, system qualification and preventative maintenance that reduce operating costs and maximize lab productivity. Our experienced team of technical support, FAS and applications development scientists are always available for research consultation.

Request a Quote, Demo or More Info

Features of the Octet® Platform

Octet® R8 touchscreen

Label-free assays measure molecular binding through real-time protein interactions. It is a precise and efficient means of collecting a wide range of information related to affinity, kinetics, concentration, thermodynamics, bio-similarity, specificity, potency and selectivity of molecular binding.

Octet® is a powerful platform designed to understand structure-function relationships between molecules, and it can be applied at many different stages throughout the drug development process.

Fluidic-free Octet® BLI assays are ideal for measurements in crude and complex matrices for instance titer and concentration analysis as well as screening for Critical Quality Attributes (CQAs) early in cell line development and bioprocess development workflows.

On the other hand, working with challenging analytes such as small fragments in FBDD, low affinity molecules or high affinity binders require a higher sensitivity that only Octet® SPR technology can offer. The patented OneStepTM gradient injection generates unique curvature to accurately detect full binding kinetics (kon, koff and KD) from a single concentration.

Label-free BLI and SPR are used from screening (at the very early stages of drug discovery) to identifying and engineering potential binding candidates, supporting clinical evaluation and finally during quality control(QC) of GMP manufacturing.

Over the last two decades, these systems have been upgraded to show significant improvements in sensitivity and software capabilities, leading to higher workflow efficiencies and more unlocked applications.

Featured Protein Analysis Instruments

Octet® SF3 SPR

Octet® SF3 SPR 

Generate high-quality kinetics and affinity data in a fraction of the time compared to standard multi-cycle kinetics using the Octet® SF3.

Explore Octet® SF3

Octet® R Series

Accelerate your research with a field-upgradeable, label-free biomolecule analysis platform.

Discover the R Series

Educational Resources

7000+ Octet publications New

Octet® Publication Database

Literature references covering a large variety of research areas and applications

Search Featured Publications
A compendium for successful BLI and SPR assays
Application Guide

A Compendium for Successful BLI and SPR Assays

Octet® Label-Free Biosensor Analysis

Access the Guide
app note cover
Application Note

Biomolecular Binding Kinetics Assays on the Octet® Platform

Introducing label-free platforms, the technology, capabilities, and advantages of label-free binding assessment

Access Application Note
Octet Kinetics Assay Method Development Guideline thumbnail
Technical Note

Octet® Kinetics Assay Method Development Guideline

Developing kinetics binding assays to establish specificity, accuracy, precision, linearity and range as stipulated by USP 1032

Access Technical Note
app note thumbnail
Application Guide

A Simple Method to Determine Relative Potency (EC50)

Using Octet® BLI Technology

Access Guide
Analysis of Fc-Gamma Receptor-IgG Interactions on the Octet® Platform
Application Note

Analysis of Fc Gamma Receptor IgG Interactions on Octet® Platform

Whether you're assessing FcRn-Antibody or FcγR-IgG binding interactions, you need a high throughput, versatile, and easy to use solution.

Access Application Note
Case Study

Bispecific Antibodies: From Research to Clinical Application

Learn how Octet BLI transforms our approach to drug discovery and development

Read Case Studies

Streamline CLD Workflows With Integrated Instruments

Discover how Sartorius’ innovative products and expert knowledge can provide an efficient and scalable solution to CLD

Watch Now

Request a Quote, Demo, or More Information

What other areas are you interested in? (select all that apply)

Request a Quote, Demo, or More Information

Related Content


Applications for Label-Free Detection

Explore More

Octet® System Service and Support

Explore More

Octet® BLI Resources

Explore More
Ready to Buy?