Label-Free Protein Analysis and Characterization

Biologics Characterization Tools

Industry Standards for Screening, Characterizing Biomolecular Interactions (Including Antibodies)

The Octet® platform is a comprehensive solution for screening and characterizing molecular interactions such as protein-protein or protein-drug, enabling an enviable variety of applications throughout biologics development from early selection to validation to manufacturing.

Our instruments utilize industry-leading, label-free technologies - Bio-Layer Interferometry (BLI) and Surface Plasmon Resonance (SPR). Both are deemed appropriate for bioanalysis within chapters of the United States Pharmacopeia (USP).

The Octet® family of instruments has been an industry standard for label-free analysis across biologics development and manufacturing for more than 15 years.

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Sartorius Solutions for Biologics Characterization

Scientists with the Octet RH96

Octet® Label-Free BLI Detection Systems

Ideal for titer and concentration analysis as well as screening for CQAs early in cell line development and bioprocess development workflows

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Octet SF3 SPR System

Octet® SPR Detection

Generate the most accurate data possible in the shortest timeframe imaginable. Simplifies kinetic characterizations and fragment screens.

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Why Choose Sartorius for Label-free Biomolecular Interaction Analysis? 

Continuous Innovation

As a trusted scientific partner, we deliver unique solutions to research challenges. Our goal is to provide best-in-class products for real-time analysis of biomolecular interactions in micro-volume sample sizes, providing information on affinity, kinetics and concentration.

Extensive Publication Success

Label-free systems from Sartorius have become indispensable tools in academic and biopharmaceutical research, from characterizing binding interactions and specificity to engineering proteins and antibodies. We have more than 5000 publications on the use of Octet® products within various applications.

World Class Service

Our comprehensive service plans include validation, system qualification and preventative maintenance that reduce operating costs and maximize lab productivity. Our experienced team of technical support, FAS and applications development scientists are always available for research consultation.

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Features of the Octet® Platform

Label-free assays measure molecular binding through real-time protein interactions. It is a precise and efficient means of collecting a wide range of information related to affinity, kinetics, concentration, thermodynamics, bio-similarity, specificity, potency and selectivity of molecular binding.

Octet® is a powerful platform designed to understand structure-function relationships between molecules, and it can be applied at many different stages throughout the drug development process.

Fluidic-free Octet® BLI assays are ideal for measurements in crude and complex matrices for instance titer and concentration analysis as well as screening for Critical Quality Attributes (CQAs) early in cell line development and bioprocess development workflows.

On the other hand, working with challenging analytes such as small fragments in FBDD, low affinity molecules or high affinity binders require a higher sensitivity that only Octet® SPR technology can offer. The patented OneStepTM gradient injection generates unique curvature to accurately detect full binding kinetics (kon, koff and KD) from a single concentration.

Label-free BLI and SPR are used from screening (at the very early stages of drug discovery) to identifying and engineering potential binding candidates, supporting clinical evaluation and finally during quality control(QC) of GMP manufacturing.

Over the last two decades, these systems have been upgraded to show significant improvements in sensitivity and software capabilities, leading to higher workflow efficiencies and more unlocked applications.

Featured Label-Free Octet® Systems

Octet® SF3 SPR

Octet® SF3 SPR 

Generate high-quality kinetics and affinity data in a fraction of the time compared to standard multi-cycle kinetics using the Octet® SF3.

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The Octet® BLI is an easy-to use, real-time analytical tool that rapidly screens critical quality attributes.

2-Channel System: Octet® R2

Grows With Your Biomolecule Characterization Needs

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4-Channel System: Octet® R4

The Perfect Balance Between Cost and Throughput with Given Leeway

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Octet R8 instrument

8-Channel System: Octet® R8

Unmatched Flexibility and Versatility in Protein Analysis

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16-Channel High Throughput Octet System: Octet® RH16

Ideal for high-throughput applications that demand high sensitivity and low sample volume requirements

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Octet® BLI rapidly determines recombinant protein concentration as a control parameter in cell line development.

96-Channel Ultra High Throughput Octet System: Octet® RH96

Monitors up to 96 biosensors simultaneously, enabling label-free detection for protein quantitation and kinetic characterization at unmatched speed

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Streamline CLD Workflows With Integrated Instruments

Discover how Sartorius’ innovative products and expert knowledge can provide an efficient and scalable solution to CLD

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