Research the Industry Standards for Label-Free Analysis of Biomolecular Interactions

The Octet® and Pioneer® platforms are enabling label-free instrument platforms based on Bio-Layer Interferometry (BLI) and Surface Plasmon Resonance (SPR) technology.  Download the latest Application Notes, Infographics, Guides & more to further your label-free research.

Featured Octet® Resources

Biomolecular Binding Kinetics Assays on the Octet® Platform thumbnail

Biomolecular Binding Kinetics Assays on the Octet® Platform

Introducing label-free platforms, the technology, capabilities, and advantages of label-free binding assessment in therapeutics development and...

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Brochure: Octet® R Series Systems

Accelerate your research with an upgradeable, label-free protein analysis platform

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Octet® AAV ROI Flyer

AAV Capsid Titer Data 80% Faster Compared to ELISA

Bioprocess Five Additional Batches of AAV Samples Annually

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Determining Nanoparticle Vaccine Antigenic Efficiency

Nanoparticle (NP) vaccine and antigen delivery platforms have emerged as a promising approach due to their ability to interact with immune...

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Stability, Formulations and Aggregation Studies

Expanding Octet Applications in Downstream Biologics Characterization

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Accurate Measurements on the Octet Platform

Without Added Sample Purification Steps

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Advancing Development of Coronavirus Vaccine and Therapeutics

BLI Technology Plays a Vital Role in the Race for a SARS-CoV-2 Treatment

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Octet Kinetics Assay Method Development Guideline

Aimed at developing kinetics binding assays to establish specificity, accuracy, precision, linearity and range as stipulated by the USP 1032...

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Recent Insights into Covid-19 Binding Epitorpes

Bio-Layer Interferometry (BLI) technology is helping scientists around the world learn more about the recent Coronavirus (COVID-19) outbreak. In...

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Octet® R Series Glycan shadow visual

Mannose Glycans Content Screening for Human-mAb Samples

The Octet® GlyM Kit is designed to provide cell line development and upstream bioprocessing groups with a ready to use kit for the rapid relative...

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Biomolecular Binding Kinetics Assays on the Octet® Platform thumbnail

Biomolecular Binding Kinetics Assays on the Octet® Platform

Introducing label-free platforms, the technology, capabilities, and advantages of label-free binding assessment in therapeutics development and...

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Validated Quantitation and Activity Assay of Antibody Fragment Molecule (Fab) for Process Development and Quality Control

Validated Quantitation and Activity Assay of Fab Molecule for...

The group was able to develop a working Fab activity assay on the Octet RED system in less than a week. Relative to the overnight incubation and...

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Cross Competition or Epitope Binning Assays on Octet® RH96 System cover image

Cross Competition or Epitope Binning Assays on the Octet® RH96 System

Epitope binning through cross competition assays is a powerful tool in evaluating functional diversity in antibody clones.

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Cover: Characterizing Membrane Protein Interactions by Bio-Layer Interferometry

Characterizing Membrane Protein Interactions by Bio-Layer...

Example studies on how the Octet® system can be used to analyze membrane protein interactions, even allowing the use of unpurified crude matrices...

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Octet® Systems: Modernize Biopharmaceutical QC Testing to Increase Efficiency

Modernize Biopharmaceutical Quality Control Testing

Quality control of biological products to support clinical trials and post market assay activities require the evaluation of multiple critical...

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Analysis of Fc-Gamma Receptor-IgG Interactions on Octet Platform

Whether you're assessing FcRn-Antibody or FcγR-IgG binding interactions, you need a high throughput, versatile, and easy to use solution.

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Cross Competition or Epitope Binning Assays on the Octet® RH96 System

Read our newest Application Note to learn how the powerful Octet® HTX system is ideally suited to perform high throughput epitope binning/cross...

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Analysis of FcRn-Antibody Interactions on Octet Platform

Assay design recommendations and best practices for producing the highest quality of kinetic data.

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Customized Quantitation of Recombinant Therapeutic Proteins

Using High Precision Streptavidin Biosensors (SAX)

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Label-Free Technologies for Accurate Determination of Affinity and...

From target molecule identification to lead selection and optimization, equilibrium affinity and kinetics rate constants are critical parameters...

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MAb Quantitation Protein A HPLC vs Protein A Bio-Layer Interferometry

Rapid, accurate and cost-effective quantitation of monoclonal antibodies (MAbs) is essential for bioprocessing.

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Octet Potency Assay Development Qualification and Validation...

Real-time data on affinity and the kinetics of binding can provide useful information at every stage of biopharmaceutical reagent development.

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Quantitation of Fc-Fusion Protein in Cell Culture Supernatants

The cell line development group at Biogen IDEC needed a robust assay for the measurement of Fc-fusion protein (Protein 1) in crude cell culture...

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A Rapid Method to Quantitatively Screen Bispecific Antibody Using Protein A and His1K Biosensors cover

Screen Bispecific Antibody Using Protein A and His1K Biosensors

Rapid quantitative screening of bispecific antibodies using Protein A and HIS1K biosensors

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eBook: How Are Label-Free Technologies Used in Early Drug Discovery?

How Are Label-Free Technologies Used in Early Drug Discovery?

Modern analytical techniques designed for real-time analysis and high-throughput capabilities significantly reduce the time to the discovery

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Label-Free Detection Technologies: Key Considerations and Applications cover

Label-Free Detection Technologies: Key Considerations and Applications

Binding interactions in biological samples are dynamic and driven by changes to the environment. The techniques used to characterize these...

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Infographic

Infographic: Understanding Covid-19 Vaccine and Therapeutic...

Learn more about how Octet systems are used to advance Coronavirus research and vaccine development

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Influenza Vaccine Titre Determination Bio-Layer Interferometry (BLI)

Fast, accurate determination of vaccine titre during influenza vaccine manufacture is important in understanding process performance and...

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Octet® Bio-Layer Interferometry (BLI) Technology

Label-free alternative for characterizing protein-protein and drug-protein interactions in standard microtiter plate format

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High productivity and process economy in GxP applications with Octet

Quantitation assays must show precision, accuracy, linearity, and reproducibility. To be used for GMP applications, they must be developed with...

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Investigating Synthetic Immune Recruitment by Proximity Inducing Molecules - White Paper

Investigating Synthetic Immune Recruitment by Proximity Inducing...

In this white paper, we describe the development of Octet® Bio-Layer Interferometry (BLI) assays that validate and characterize bi-functional...

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Streamlining Affinity Analysis for Accelerated Lead Screening

Antibody and other protein therapeutics are a major focus in drug discovery pipelines today. The overall process for developing protein...

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Writing Grant Proposals for Biomolecular Interactions Research

Grant writing can be a grind. You know how and why the funding is needed, but communicating that successfully sometimes seems like an art.

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Automating Octet Assays for Ligand Screening

Drug development and production is challenging. Avitide, based in Lebanon, New Hampshire, provides on-demand development and supply of...

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Enhanced Efficiency in Lot Release and In-Process Testing of Biologics cover

Enhanced Efficiency in Lot Release and In-Process Testing of Biologics

Bio-Layer Interferometry (BLI) is an optical technique that analyzes the interference pattern of white light reflected from two surfaces: a layer...

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Biologics Characterization Tools

Industry Standards for Label-Free Analysis of Biomolecular Interactions

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