Solutions for Discovery of Viral Vaccines & Vectors

Groundbreaking Technologies and Associated Services to Enable Researcher to Accelerate and Advance Discovery and Development of Viral Vaccines & Vectors

Although a great deal of progress has been made in vaccine research, recent headlines remind us that we still have much to do to advance and accelerate the discovery process.

The recent global outbreak of coronavirus diseases (COVID-19) caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2) serves as a stark reminder of the imminent threat of unexpected pathogens. We need a deeper understanding of the cellular and molecular mechanisms that drive immune responses against emerging infectious diseases (EIDs). See how Sartorius' innovative,  groundbreaking solutions advance and accelerate your discovery and development of new vaccines against viral infections.


Cell Analysis Platforms

For tracking complex host - pathogen biological processes, you need high-capacity cell analysis solutions to generate deeper, more relevant data on phenotype, activation, and function.

  • Studying host - pathogen interaction
  • Indentification and selection of potential antigens
  • Analysis of Immune responses

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All-in-One Octet® Platforms - From Therapeutic Investigations to Bioproduction

Speed up your time to results with easy-to-use, fluidics free label free detection systems. A range of platforms to choose from depending on your throughput needs. See  how Octet® system can help accelerate covid-19 vaccine and therapeutics research.

Explore Octet® Systems

View our complete list of publications on coronavirus research

Octet® Label-Free Bio-Layer Interferometry (BLI) Detection Systems

The Octet® Bio-Layer Interferometry (BLI) platform offers unprecedented time and cost savings during biomolecular interactions analysis.  Octet systems accelerate COVID-19 research, and will help you to:

  • Select vaccine and therapeutics candidates faster
  • Categorize antibodies into epitope bins efficiently
  • Simplify workflows through our wide variety of available biosensors
  • Facilitate titer, potency and stability measurements in upstream and downstream vaccine and biotherapeutics development and manufacturing 
  • Analyze data with intuitive easy-to-use software tools 

Octet® Featured COVID Research

Analysis of coronavirus binding to host receptors - Affinity and kinetics of virus-host receptor binding interactions are crucial to understanding viral pathogenesis and therapeutic development approaches. Octet platforms enable fast and accurate analysis of binding interactions in real-time.
Read More by Walls et al.  Cell, 2020 

Screen and characterize inhibitors of virus-host receptor interactions -  Targeting the virus-host receptor recognition is one of the main strategies to prevent viral entry. Octet platforms provide a high-throughput and convenient solution to rapidly screen, characterize and validate peptides, antibodies, FAB and scFv molecules that block coronavirus - host receptor interactions. 
Read More by Zhang et al. bioRxiv, 2020
Read More by Wu, Y et al., Cell host and Microbe, 2020 

Epitope Binning - Epitope binning analysis help identify antibody groups that bind to the same epitope on a target antigen. See how Octet assays were used to classify antibodies into epitope bins and identify antibodies with synergistic neutralization activity.
Read More by Pinto et al. Nature, 2020

Accelerate neutralization antibody development workflows - See how Octet assays are being used  in coronavirus neutralization antibody discovery and characterization workflows from antibody clone screening, receptor blocking assessment, affinity and kinetic characterization to epitope binning assays. 
Read More by Zost et al, bioRxiv, 2020
Read More by Wu, Y et al., Science, 2020

iQue®️ Advanced Flow Cytometry Platform

Advanced flow cytometry platform to get from samples to actionable results in record time.

The iQue® Advanced Flow Cytometry Platform can be used for viral research activities such as monitoring host-pathogen interactions, antibody library screening, immune response assessment, epitope mapping, and antibody neutralization studies.

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Antibody Library Screening

Screening of Ab libraries against cell surface proteins that play a key role in virus inhibition.
Read more about how the iQue can help to screen antibodies for their ability to limit infections by Stein et al. Nature Communications, 2019


Epitope Mapping

Screening of mutagenesis library to determine the epitopes recognized by human mAbs.
Read more by Williamson et al. Journal of Virology, 2019
by Collins et al. JCI Insight, 2019

Development of therapeutic antibody cocktails against Ebola virus.
Read more by Gilchuk et al. Immunity, 2020
 


Antibody Neutralization

Neutralizing antibodies have the potential of therapeutic agents.
See how a potently neutralizing human monoclonal antibody with postexposure therapeutic activity against ZIKV infection was developed in a mouse model.
Read more by Long et al. PNAS, 2019

Incucyte® Live-Cell Analysis System 

In the race for a vaccine, accelerating biological insight is critical. The Incucyte® Live-Cell Analysis System improves productivity with powerful, automated image acquisition. Accelerate your next discovery with a flexible assay platform that accommodates multiple applications simultaneously with multi-plate throughput. Protect your cells and your team, by performing analysis with networked, remote access as your cells remain in the physiologically relevant environment of the incubator.  With automated analysis and a portfolio of reagents, consumables and software specifically designed to detect dynamic immune response, solving biologically relevant questions has never been easier!

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Revealing host - virus interactions and molecular interactions within RNA replication complexes by monitoring and analysing of transfected cells continuously.
Read more by Kyungeun et al. The International Journal of Biochemistry & Cell Biology, 2014

Employing transposon mutagenesis to investigate foot-and-mouth disease virus replication.
Read more by Morgan et al. Journal of General Virology, 2015


Cell Viability Assays

Studying mechanism of infection through assessing virus modulated cell death.
Read more by Guo et al. Cell Host & Microbe, 2015

Learn more about Cell Health & Viability Assays


Viral Titers and Antiviral Screening

Incucyte® Live-Cell Analysis System enables fast, efficient and accurate measurement of infectious viral titers by providing a highly flexible fixed cell analysis protocol suitable for antiviral screening.


A novel method for the measurement of hepatitis C virus infectious titers using the Incucyte® Live-Cell Analysis System  and its application to antiviral screening.
Read more by Stewart et al. Journal of Virological Methods, 2015

Webinar: Detailed Antibody Characterization Enabled by High Throughput Flow Cytometry -  Intellicyt®

See how Intellicyt®, high-throughput flow cytometry platform can help characterizing antibodies against proteins natively expressed on cells.


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Viral Replication and Infection Assays

Viral replication and infection assays enable the study of pathogenesis in host cultures and the testing of novel antiviral therapeutics. 

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Viral Therapeutics and Vaccine Development

Development of an influenza virus pseudotyped with Ebolavirus glycoprotein to aid therapeutic screening.
Read more by Xiao JH et al.  J Virol. 2018 Jan 30;92(4)


Continuous monitoring of intracellular viral spread

Measuring confluence of virus positive cells over time.
Read more by Andreu-Moreno et al. Current Biology, 2018



Target Identification

Delve Deeper Into the Biology of T Cell Exhaustion With Our New Human T Cell Exhaustion Cell and Cytokine Profiling Kit

Explore Profiling Kits

Virology Assays

Explore the Entire Host-Pathogen Life Cycle with Advanced Cell Analysis Solutions.

Discover Virology Assays
Other Featured Cell Analysis Applications

T Cell Characterization

Gaining deeper insights into therapeutic development with in-depth T Cell Characterization.

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Cytotoxicity

Detect real-time measurements of cell death based on cell membrane integrity.

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Apoptosis

Investigate aberrations in apoptotic pathways in intact, living cells.

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Immune Cell Clustering and Proliferation

Understand the mechanisms of immune cell activation, proliferation and regulation.

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iQue® Advanced Flow Cytometry Platform

Advanced flow cytometry platform to get from samples to actionable results in record time. Evaluate cytotoxicity, apoptosis and other biological...

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Viral Replication and Infection Assays

Viral replication and infection assays enable the study of pathogenesis in host cultures and the testing of novel antiviral therapeutics.

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Reporter Genes

Measure signalling pathway activation and activity of promoter driven reporter gene expression in real time.

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Immune Cell Killing

Real time visualization and fully automated analysis of tumor cell killing.

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Next-generation chemically defined serum free, animal component free medium designed to support the growth of Vero cells

A chemically defined, animal and human component-free, serum-free media, designed to support the growth of Vero cells used in virology, virus production, and biotechnology. NutriVero™️ Flex 10 is a very low protein medium containing no proteins or peptides of human or animal origin, and it is suitable to monolayer culture and for microcarriers suspension culture of Vero cells. NutriVero™️ Flex 10 is suitable for large scale culturing and for growing viruses, as well as other cell culture applications, including production of recombinant proteins.

  • Chemically defined, serum-free, animal component free medium
  • Very low protein concentration; no proteins or peptides of animal or human origin
  • Produced in a cGMP-compliant facility in a xeno-free dedicated production line
  • Reduced risk of viral contamination
  • Lot to lot consistency
  • Ease of downstream product purification
  • Optimal for the production of various viruses

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Tools for Your Downstream Vaccine Research Applications

Clarification and Filtration

Sartoclear Dynamics® Lab V50 kits: Virus harvesting in one step
Kits combining a vacuum filtration unit, Sartolab® RF 50 with a 0.45 µm PES membrane and a filter aid for clarification.

Explore Filtration Kits

Read the Brochure

Concentration and Purification of Viruses

Vivapure® Virus Purification and Concentration Kits
Adenovirus and lentivirus purification kits utilize membrane adsorber technology for fast and safe virus purifcation.

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NEW Application Note: Ultrafiltration Methods for the Concentration and Purification of Viruses
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Concentration, Purification  and Diafiltration of proteins (antigens and antibodies)

Vivaflow®, Vivaspin® and Vivapure® Ultrafilters
Perfect solutions for your ultrafiltration needs serving the complete protein ultrafiltration workflow: From concentration and diafiltration of the original protein source, a cell culture supernatant, to final concentration | desalting of the purified protein.

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See how Vivaspin® ultrafilter was used in recent Coronavirus related research experiments for concentration of Virus Like Particles (VLPs) and proteins.

                                               
Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response. Glowacka et al. Journal of Virology - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126222/


Expression, purification and crystallization of the SARS-CoV macro domain. Malet et al. Crystallography Journals Online - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2222557/


Structure of the SARS-Unique Domain C From the Bat Coronavirus HKU4. Staup et al. SAGE Journals - https://journals.sagepub.com/doi/full/10.1177/1934578X19849202


Structure, Function, and Antigenicity of the SARSCoV-2 Spike Glycoprotein. Walls et al. Cell
- https://doi.org/10.1016/j.cell.2020.02.058  

Claristep® Filtration System

The power of symplicity.
The manually operated Claristep® Filtration System consisting of a station and filter units provides a modern, simple fix for HPLCs demanding needs.

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Blotting Papers

Soak it up right! Pure blotting paper and consistent CN membrane for reproducible results.

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Titer, Potency and Stability Measurements

Octet® quantitation assays are perfect solutions to measure antibody and vaccine titers in your process development samples that provides fast at-line testing capabilities. With a variety of ready-to-use quantitation specific biosensors, a  full 96-plate of antibody or vaccine titers can be measured within minutes using the octet.

Discover Titer Impurity Testing

Antibody Purification Miniplatform

mAb Purification Mini Platform

Sartorius’s mAb purification mini platform is ideal for small-scale purification of your mAb from up to 1 L of cell culture supernatant.
The mini platform includes up to seven steps to take you through all the workflows necessary for mAb purification: cell clarification and filtration, antibody capture by affinity chromatography, purification step(s), concentration, and sterile filtration.
Each of our application steps maximizes output for the next step in the workflow, to support a seamless mAb purification process with maximum output.

Sartorius Solutions for Pipetting & Dispensing

Picus Electronic and Tacta Mechanical Pipettes

Ergonomics – Pipetting for Your Safety

A basic but repetitive application, therefore ergonomics is key.

Discover Pipetting Solutions

Pipette Controllers and Bottle-top Dispensers

Do you need to dispense large volumes straight from a bottle or tube?

To make it easy for you, we offer handy pipette controllers and bottle-top dispensers.

Discover Dispensing Solutions

Discover the Centrisart® Centrifuge Family

Centrisart® Centrifuges

The Centrisart® Centrifuge Family portfolio ranges from very compact and space-saving micro-centrifuges to universally applicable benchtop centrifuges with a total capacity of up to 1,600 mL. Perfect for nucleic acid isolation for PCR testing.

Explore Centrifuges

Microsart® AMP Mycoplasma Kit

Ensure your results are from your cells, not contamination. Screen your cultures with our real-time PCR kit for mycoplasma contamination.

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Microsart® RESEARCH Bacteria Kit

Provides rapid detection of total bacteria within 2½ h. Use Microsart® RESEARCH Bacteria for fast and reliable real-time PCR-based detection of bacterial contamination in cell cultures or cell culture supernatants. 

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MYCAP® CCX Cell Expansion System

Reliable aseptic technique for cell culture expansion, MYCAP® CCX has a revolutionary closed design that ensures media feed, inoculation, sampling, and transfers are done aseptically—without the need for a biosafety cabinet. 

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Sample Preparation

Sartorius’s lab products for sample preparation are scalable and enable reproducible procedures. Our products cover a spectrum from weighing to sedimentation solutions to ultrafiltration units.

Optimize your sample preparation for accurate and reliable results.

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Arium®️ Pro VF or UF with Integrated Ultrafilter and Arium®️ Mini Ultrapure Water Systems with Arium®️ CellPlus Ultrafilter

Designed for efficient removal of endotoxins, RNase, DNase, microorganisms and particles. Provides the highest safety for your critical cell culture applications.

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Vaccine Manufacturing, Process Development and Production

'Single-use technologies and associated services addressing process development and productions needs of vaccine manufacturers'

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Cell Line and Media Testing Solutions

NBE Product Characterization

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Application Center

Experience Sartorius solutions for your specific application or process, as well as laboratory tasks, with industry-specific training and...

Meet our Experts

Expand Your Knowledge with a Process-Specific Consultation on Your Production Process

Sartorius Application Centers are located in Germany, China and the United States. It is your opportunity to experience Sartorius solutions for your specific bioprocess as well as laboratory tasks and applications. By meeting our industry experts you will receive a highly process- and application-specific consultation alongside hands-on tests of our cutting-edge technology.

  • Learn about market trends and how they will affect your industry
  • Experience flexible, reliable and smart equipment for your applications See which combination of equipment fit best for your current process and beyond Find out how safe and easy it is to work with single-use systems and consumables
  • Discover our customized solutions and services for your specific needs
  • Communicate and exchange know-how with our industry experts!


Sartorius Solutions for Viral Vaccine Research | Biologics Brochure

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Application Highlight: Safe-Lock Tube Holders for Cubis® Balances

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Application Highlight: Vial and Flask Holders for Cubis® Balances

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Brochure: Cubis®️ ll Sample Holders

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