Harnessing the Power of the Cellular Machinery
Harnessing the Power of the Cellular Machinery
See in our short video, how Biologic Therapeutics are developed!
Monoclonal Antibody (mAb) Therapy Discovery and Development
More Insight, Better Decisions
Therapeutic antibodies have recently emerged as not only successful immunotherapy but also as promising treatment options for infectious diseases like COVID-19. Among some already licenced monoclonal antibodies, several others are in clincal trials or in development to investigate wther they can effectively treat COVID-19 patients.
To mount a successful monoclonal antibody (mAb)-based discovery and development program, whether developing therapeutic antibodies or antibody drug conjugates, you need technologies that allow rapid identification and characterization of candidate molecules to identify those with superior target reactivity and optimized functionality.
Our unique and innovative solutions for discovery and development of mAb therapies streamline the workflow and increase productivity. Accelerate your biotherapeutic development and still have peace of mind.
Sartorius Solutions for mAb Discovery & Development
Cell and Protein Analysis Platforms
Sartorius’s cell analysis platforms offer unique, high-capacity solutions for characterizing immune phenotype and function at unprecedented speed, depth, and scale to provide information-rich data for tracking complex biological processes.
Unlike other approaches that require multiple assays or time points, our technologies reduce variability by delivering more data per time point, or across multiple time points, in the same context, under the same conditions. Using our comprehensive analysis and visualization capabilities for biologics characterization, you will have access to actionable results, faster.
Cell Analysis Platforms
Incucyte® Live-Cell Analysis System
Enables real-time, live-cell imaging and analysis directly inside your incubator. Measure kinetic effects of your antibody treatment on target cells without ever having to remove cells from the incubator.
iQue® Advanced Flow Cytometry Platform
High-throughput, suspension cell and bead analysis platform for rapidly profiling of cell phenotype and function in therapeutic antibody discovery workflows. Ideal for those screens where cells are precious or limited in number, the iQue3 is the fastest way to generate high-content data from small samples.
Protein Analysis Platform
Octet® Label-Free Bio-Layer Interferometry (BLI) Detection Systems
Biomolecular Interaction Analysis Platforms for Antibody Discovery and Cell Line Development
Octet® systems are used for affinity ranking, epitope binning of small to large antibody matrices, Fc-receptor binding, cross-reactivity testing of other species, glycosylation screening, characterization of antibody-antigen binding kinetics and affinity, bispecific testing, and titer analysis for protein expression, all in one high throughput, easiest-to-use system.
mAb Therapy Discovery & Development Workflow
Molecule Development
Candidate mAb therapy discovery and development begins with a comprehensive understanding of the biological and molecular pathways underlying disease states and a full understanding of how your candidates interrupt these processes.
You need powerful tools that can deliver multifactorial results. Sartorius’s cell analysis platforms and laboratory essentials offer unique, high-capacity solutions for molecule development, from characterizing disease pathways to understanding candidate molecule function. Screen cells in suspension and targets in their natural conformation and get better information with simultaneous acquisition of both antigen binding and cross-reactivity.
Applications for mAb Therapeutics
Related Resource
Cell Line Development
The success of your mAb development program hinges on early development of dedicated cell lines and identification of your best performers. Sartorius offers cell line development services if your plans call for outsourcing, and solutions for cell line development that you can use in-house.
Our products, services, and technologies offer innovative solutions to enable multiparametric assessment of clones, from protein concentration to cell health and viability, to rapidly and efficiently identify and rank your best performing clones.
See how clone ranking and selection can change dramatically by multiparametric assessment (IgG titer, IgG titer per cell, cell density and cell viability) of your clones, so you can screen more clones in less time and make decisions sooner.
Applications for Cell Line Development
Related Resource
Closed Membrane Filtration Systems for Sterility Testing
Our Sterisart portfolio is easy to use, minimises the risk of false positives and false negative, meets all regulatory requirements, and provides you with complete confidence in your sterility testing results. We redefine industry standards.
Applications for Microbial Testing
Featured Products
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mAb Purification Mini Platform
Sartorius’s mAb purification mini platform is ideal for small-scale purification of your mAb from up to 1 L of cell culture supernatant.
The mini platform includes up to seven steps to take you through all the workflows necessary for mAb purification: cell clarification and filtration, antibody capture by affinity chromatography, purification step(s), concentration, and sterile filtration.
Each of our application steps maximizes output for the next step in the workflow, to support a seamless mAb purification process with maximum output.
How we ensure confidence for your mAb discovery and development program
- Multifactorial, information-rich results
- Faster results, improved productivity
- More meaningful and biologically relevant insights
- Higher confidence in quality, purity, and integrity of you product
Highlight Resources
Overcoming Challenges in High Density Cell Culture Harvesting during Antibody Development
This eBook includes a collection of articles and features describing innovative solutions to accelerate and streamline the process of harvesting antibodies from high titer upstream workflows.
Key Topics:
- Facilitating mammalian cell culture development
- Overcoming the challenges of high density cell culture harvesting
- Optimizing the cell culture workflow with diatomaceous earth
- Preview of a webinar on body feed filtration for accelerated harvesting
Advancing Cancer Vaccines
New research and developments in the cancer vaccine field, and delves into the intricacies of target discovery and vaccine development.
Topics covered:
- Developing breast cancer vaccines with dendritic cell tumor fusions
- Boosting immunity with cancer vaccines: A focus on breast and ovarian cancer immunology.
Periodic Table of Antibodies
In commemoration of the 150th anniversary of Mendeleev’s Periodic Table of Elements, one of the most significant scientific tools ever published, Absolute Antibody has created their own Periodic Table of Antibodies representing all the (100+) different engineered antibody formats that they have generated utilizing Sartorius innovative products and technologies for antibody discovery and development.
Antibody Internalization: Advanced Flow Cytometry and Live-Cell Analysis Give Rich Insights During Antibody Profiling
The natural characteristics of antibodies, such as high binding affinity, specificity to a wide variety of targets, and good stability, make them ideal therapeutic candidates for many diseases. Monoclonal antibodies (mAbs), in particular, deliver promising therapeutic results in several different disease areas, such as autoimmunity, oncology, and chronic inflammation.
View all mAb Discovery & Development Resources
