Octet® BLI Label-Free Detection Systems for Biomolecular Interactions Analysis

Unprecedented Time and Cost Savings For Kinetics, Affinity, and Concentration Assays

Octet® systems enable real-time, label-free analysis for the determination of kinetics, affinity, and antibody/protein quantitation. Based on Bio-Layer Interferometry (BLI), this fluidics-free instrument platform offers a number of advantages over traditional label-free techniques like Surface Plasmon Resonance (SPR). The Octet® BLI platform also provides robust monitoring of biomolecular interactions to overcome limitations in throughput, performance, and cost associated with traditional technologies such as ELISA or HPLC. These fluidics-free, low maintenance and sensitive systems increase lab productivity, reduce costs, and shorten experimental timelines. 

With our latest additions to the Octet® portfolio, the Octet® R Series, you can choose between a 2-, 4- or 8-channel model (Octet® R2, R4, or R8) to balance budget and throughput needs. The Octet® R2 and R4 offer field upgradeability to futureproof your research and your investment. 

Accelerate your research with systems that offer:

  • Higher Throughput - Protein quantitation in as little as two minutes, and parallel processing of up to 96 samples. 
  • Fast Time to Results – Automated analysis for faster time to market and faster publications.
  • Real-time Analysis – Binding interactions are continuously monitored as they happen. Don’t miss out on subtle kinetic behavior patterns.
  • Crude Sample Compatibility - Analytes can be measured in crude, unpurified mixtures such as cell lysates or hybridoma supernatants.  Octet® systems tolerate glycerol and up to 10% DMSO.
  • Ease of Use – Simple, integrated user interface designed for biologists. Spend less time learning instrumentation and more time deriving insights.
  • Low Total Cost of Ownership – Low maintenance system has no fluidics modules to clog, so no downtime while waiting for replacements

Discover Biolayer Interferometry (BLI) Technology

Octet® R Series

Accelerate Your Research with an Upgradeable, Label-Free Protein Analysis Platform

2-Channel System: Octet® R2

Grows With Your Biomolecule Characterization Needs

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4-Channel System: Octet® R4

The Perfect Balance Between Cost and Throughput with Given Leeway

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8-Channel System: Octet® R8

Unmatched Flexibility and Versatility in Protein Analysis

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Octet® RH16 and RH96

Unprecedented Throughput for Industry Applications

96-Channel Ultra High Throughput Octet System: Octet® RH96

Monitors up to 96 biosensors simultaneously, enabling label-free detection for protein quantitation and kinetic characterization at unmatched speed

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16-Channel High Throughput Octet System: Octet® RH16

Ideal for high-throughput applications that demand high sensitivity and low sample volume requirements

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Octet®️ N1 – Label-Free Assays in a Drop

Octet® N1

Label-free assays in a drop

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Sartorius Solutions for Label-Free Detection Systems

Octet HTX
Analyze samples in crude matrix

Use the fluidics-free Octet systems with 96- and/or 384-well sample plates and the ready-to-use biosensors for flexibility in sample types; from large biologics to small molecules, purified or in crude form.

Transfer methods to QC and manufacturing with confidence

Rapidly develop and validate Octet methods for lot release ligand binding, quantitation, and impurity assays.

Featured Resources

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Octet R Series System brochure cover

Brochure: Octet® R Series Systems

Accelerate your research with an upgradeable, label-free protein analysis platform

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Biomolecular Binding Kinetics Assays on the Octet® Platform thumbnail

Biomolecular Binding Kinetics Assays on the Octet® Platform

Introducing label-free platforms, the technology, capabilities, and advantages of label-free binding assessment in therapeutics development and...

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