Aseptic Disconnections
Adaptable, Reliable Solutions for Disconnection
As biomanufacturing increasingly adopts single-use solutions, reliable disconnections are critical for maintaining closed systems. Process integrity and operator safety depends on the technology. Plans to aseptically disconnect these systems must be part of the overall process plan to ensure proper containment.
User-friendly design based on years of customer feedback and experience.
Varied disconnection options to meet customers’ containment, cost and critical process needs.
Scalable thermal and mechanical disconnection technologies ease adoption of single-use technologies from R&D to commercial processes.
Disconnect With Confidence
Sartorius offers a complete portfolio of disconnection technologies for single-use systems and unit operations. By matching process needs with disconnection technology capabilities, biomanufacturers can streamline and protect valuable process fluids. Review the solutions below to understand the range of options available.
Biosealer® TC | Clipster® | Quickseal® | Triclamp | Quick Couplers | |
|---|---|---|---|---|---|
Type of connection | Sterile | Sterile | Sterile | Non-sterile | Non-sterile |
Maintains Sterility in Non-classified Environments | Yes | Yes | Yes | No | No |
Time | 1-4 mins | 45 secs | 5-10 secs | 1 min | < 30 sec |
Cost per Connection | $ * | $$ ** | $$ ** | $$$$ | $ |
Fluid contact materials (aside from tubing) | None | None | None | Polyethylene, gasket & cap | Polycarbonate/ Polysulfone |
Typical tubing material | TPE Only | TPE / Silicone | TPE / Silicone | TPE / Silicone | TPE / SIL / EVA |
Size range | 1/4" – 1" OD | 1/4" – 3/4" OD | 1/8" — 1.125" OD | 1/8" — 1" ID | 1/8" — 3/4" ID |
Process flexibility | As needed, with no pre-defined location | As needed, with no pre-defined location | Pre-designed in SU assembly | Pre-designed in SU assembly | Pre-designed in SU assembly |
| Learn More | Learn More |
* Requires initial capital expenditure
** Requires a small hand tool
Biosealer® TC For Robust and Consistent Sealing
The Biosealer® TC is an automated sealer for aseptic disconnection of thermoplastic tubing. This innovative technology allows sterile disconnection of dry or liquid-filled TPE tubing from 1/4" to 1" outer diameter. The Biosealer® TC seals TPE tubes by thermally bonding the tubing, ensuring a high level of stability for sterile disconnection.
Clipster® Aseptic Disconnectors
The Clipster® range of disconnectors allows fast and reliable aseptic disconnection in biopharmaceutical manufacturing operations. Its unique design allows unplanned disconnections at the point of use.
Quickseal® Aseptic Disconnectors
Quickseal® disconnection is a simple one-step cut technology to form an aseptic seal. Quickseal® collars are pre-installed on silicone or thermoplastic elastomer tubes, giving clear instructions where to cut.
Learn about the importance of building disconnection technology redundancies into the biopharmaceutical manufacturing process to mitigate risks and disruptions.
