Biosealer® TC Aseptic Tube Sealing Device
Automated Aseptic Thermoplastic Tubing Disconnection
Progressive biomanufacturing processes require advanced tools to reliably disconnect components. The Biosealer® Total Containment (TC) is an automated heat sealer for disconnecting thermoplastic tubing in an aseptic operation maintaining sterile fluid paths. The Biosealer® TC handles disconnections between disposable assemblies used in biopharmaceutical manufacturing processes and individual components of assemblies, even in non-sterile environments, while maintaining the product’s sterility.
- Use tube sizes from 1/4" to 1" OD — no accessory needed
- Dry, wetted or liquid-filled tubes
Preset for sealing up to 6 sizes of the industry’s 5 most-used TPE tubing types*
- Lightweight
- Goes with operator to disconnection site
- Use in tabletop or hanging mode
- 20 mm wide seal for robust disconnection
- Operator uses embedded cutting guide for scissor snip
Discover the Simplicity of the Biosealer® TC
The Biosealer® TC simplifies heat-sealing with a user-friendly portable design, highly stable thermal seals and a new level of flexibility. See the video to learn how the Biosealer® TC enhances thermoplastic tube-sealing.
Market-Leading Sealing Performance
Versatile Automated Sealing Device
The Biosealer® TC automated sealing device provides a simple, flexible, and fast solution for making sterile disconnections across all biopharmaceutical manufacturing processes. It can be used on disposable bags, unit operations and single-use tubing assemblies and can seal wet, dry or liquid-filled tubing.
Biosealer® TC Aseptic Sealing Device | |
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Intuitive user interface | Selecting the tubing material and size to be sealed is very easy using Biosealer® TC touch screen. Operators are then guided in a step-by-step process displayed on the screen. |
Variety of qualified materials | Compatible with Tuflux® TPE, C-Flex® 374, AdvantaFlex®, Sanipure™ BDF™ and PharMed® BPT. |
Variety of tube sizes and conditions | Has 1/8" × 1/4" up to 3/4" × 1" (ID × OD) capability, including liquid-filled conditions, no accessory needed. |
Portability | The Biosealer® TC is lightweight and can be operated on a table or while hanging. Plus, the Biosealer® TC is portable and can be moved to where the sterile disconnection is desired. |
Stable sealing | The Biosealer® TC offers a wide 20 mm seal for more robust disconnection. In addition, a cutting guideline embedded into the seal ensures operators can make a clean cut with scissors. |
Four Easy Steps to a Strong Seal
Biosealer® TC Applications
Disconnect With Flexibility
Biosealer® TC can seal wet, dry or liquid-filled tubing in non-classified and classified environments while maintaining product sterility.
Disconnect at Every Step
From small-scale upstream processes to final filling applications in large commercial productions, the Biosealer® TC adapts to changing disconnection needs.
Disconnect Across Applications
Create sterile seals for cell line development, cell and gene therapeutics and the production of mAbs, vaccines, and biosimilars.

Biosealer® TC Components and Accessories
Maximize sealing ability and smooth operations with useful accessories. Regular Sartorius service maintains peak performance.
Biosealer® TC System
The Biosealer® TC is a robust, flexible and easy-to-use device that generates sterile TPE tubing disconnections.
Accessories
Ensure top Biosealer® performance with a temperature calibration kit. Enhance the device’s portability with a 3 m extension cable.
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*Including Tuflux® TPE, C-Flex® 374, AdvantaFlex®, SaniPure™ BDF ™ and PharMed® BPT . C-Flex®, SaniPure™ and PharMed® are registered trademarks of Saint-Gobain Performance Plastics Corporation. AdvantaFlex® is registered trademark of AdvantaPure.