Biosealer® TC Aseptic Tube Sealing Device

Automated Aseptic Thermoplastic Tubing Disconnection 

Progressive biomanufacturing processes require advanced tools to reliably disconnect components. The Biosealer® Total Containment (TC) is an automated heat sealer for disconnecting thermoplastic tubing in an aseptic operation maintaining sterile fluid paths. The Biosealer® TC handles disconnections between disposable assemblies used in biopharmaceutical manufacturing processes and individual components of assemblies, even in non-sterile environments, while maintaining the product’s sterility. 

Flexible
  • Use tube sizes from 1/4" to 1" OD — no accessory needed
  • Dry, wetted or liquid-filled tubes
Ready-to-Use

Preset for sealing up to 6 sizes of the industry’s 5 most-used TPE tubing types*

Portable
  • Lightweight
  • Goes with operator to disconnection site
  • Use in tabletop or hanging mode
Highly Stable
  • 20 mm wide seal for robust disconnection
  • Operator uses embedded cutting guide for scissor snip

Discover the Simplicity of the Biosealer® TC

The Biosealer® TC simplifies heat-sealing with a user-friendly portable design, highly stable thermal seals and a new level of flexibility. See the video to learn how the Biosealer® TC enhances thermoplastic tube-sealing.

Consult our Experts



Market-Leading Sealing Performance

Versatile Automated Sealing Device

The Biosealer® TC automated sealing device provides a simple, flexible, and fast solution for making sterile disconnections across all biopharmaceutical manufacturing processes. It can be used on disposable bags, unit operations and single-use tubing assemblies and can seal wet, dry or liquid-filled tubing.

Request a Quote


Biosealer® TC Aseptic Sealing Device

Intuitive user interface

Selecting the tubing material and size to be sealed is very easy using Biosealer® TC touch screen. Operators are then guided in a step-by-step process displayed on the screen.

Variety of qualified materials

Compatible with Tuflux® TPE, C-Flex® 374, AdvantaFlex®, Sanipure™ BDF™ and PharMed® BPT.

Variety of tube sizes and conditions

Has 1/8" × 1/4" up to 3/4" × 1" (ID × OD) capability, including liquid-filled conditions, no accessory needed.

Portability 

The Biosealer® TC is lightweight and can be operated on a table or while hanging. Plus, the Biosealer® TC is portable and can be moved to where the sterile disconnection is desired. 

Stable sealing

The Biosealer® TC offers a wide 20 mm seal for more robust disconnection. In addition, a cutting guideline embedded into the seal ensures operators can make a clean cut with scissors.

Four Easy Steps to a Strong Seal

Step 1

Insert TPE Tubing

Insert the TPE tubing in the device where the sterile disconnection is desired.

Step 2

Press Start

One click on the touch screen is sufficient to start the sealing process. Just follow the instructions displayed.

Step 3

Remove TPE Tubing

When the sealing process is complete, the lid automatically reopens.

Step 4

Cut the Sealed TPE Tubing

After visual inspection of the sealing, use scissors to cut through the guideline on the sealed tubing. Done!

Biosealer® TC Applications

Disconnect With Flexibility

Biosealer® TC can seal wet, dry or liquid-filled tubing in non-classified and classified environments while maintaining product sterility.

Disconnect at Every Step

From small-scale upstream processes to final filling applications in large commercial productions, the Biosealer® TC adapts to changing disconnection needs.

Disconnect Across Applications

Create sterile seals for cell line development, cell and gene therapeutics and the production of mAbs, vaccines, and biosimilars.

Take a Closer Look

Biosealer® TC Components, Accessories and Services

Maximize sealing ability and smooth operations with useful accessories. Regular Sartorius service maintains peak performance.

Biosealer® TC System

The Biosealer® TC is a robust, flexible and easy-to-use device that generates sterile TPE tubing disconnections.

Request a Quote

Accessories

Ensure top Biosealer® performance with a temperature calibration kit.
Enhance the device’s portability with a 3 m extension cable.

Instrument Services

Regular maintenance by Sartorius service engineers ensures top performance. Qualified services are available for GMP environments.

Consult our Experts

Related Products

Sartorius Provides Complete Tube Sealing and Welding Solutions.

Tuflux® Silicone and TPE Tubing

Tuflux® Tubing is available in both silicone and TPE formulations. Both types have excellent extractable/leachable profiles.

Explore Tuflux®

Biowelder® TC Sterile Tube Welding Device

The Biowelder® TC is an automated device for connecting thermoplastic tubing in a sterile welding operation.

Explore Biowelder® TC

Consult Our Experts

Consult Our Experts

Related Topics

Opta® SFT Aseptic Tube Connectors

Opta® SFT aseptic tube connectors allow fast and reliable sterile connection and fluid transfer between two pre-sterilized process components.

Explore Opta® SFT

Clipster® Aseptic Point-of-Use Disconnectors

Clipster® is a single-use solution for disconnecting tubing at any stage in the process while maintaining sterility.

Explore Clipster®

Quickseal® — Reliable Aseptic Disconnection

Installed on an array of tube materials, Quickseal® provides reliable and rapid aseptic tube disconnection. 

Explore Quickseal®

*Including Tuflux® TPE, C-Flex® 374, AdvantaFlex®, SaniPure™ BDF ™ and PharMed® BPT   . C-Flex®, SaniPure™ and PharMed® are registered trademarks of Saint-Gobain Performance Plastics Corporation. AdvantaFlex® is registered trademark of AdvantaPure.