Achieve Robust Purification Performance With Sartobind Convec® Membranes
Ensure high recovery, linear scalability, and superior purity in your purification workflows. Our state-of-the-art membrane chromatography solutions are engineered to meet the demands of modern bioprocessing, helping you enhance productivity through improved yield and selectivity in downstream processing.
Find the Right Solution
| Attributes | Sartobind® Q Gamma | Sartobind Convec® D | Sartobind Convec® SC |
|---|---|---|---|
| Ligand | Quaternary amine | Diethylamine (DEAE) | Sulfated cellulose |
| Functionality | Strong anion exchange | Weak anion exchange | Strong cation exchange, pseudo-affinity |
| Bed Height | Mode of Operation | 4 mm and 8mm in flow through and bind | elute | 8 mm for bind | elute | 8 mm for bind | elute |
| Common Use | Capture of adenovirus and pDNA and removal of endotoxins and impurities (i.e., DNA and host cell proteins) | Purification of lentivirus and extracellular vesicles (i.e., exosomes) | Capture of vaccines and VLPs, e.g., influenza, rabies, and encephalitis |
| Product Format | Membrane Volume | Nano (1 mL) to 30" capsule (1.2 L) | Nano (3 mL) to 30" capsule (1.2 L) | Nano (3 mL) to 30" capsule (1.2 L) |
| View Products | View Products | View Products |
Sartobind® Q Gamma: Aseptic Bioprocessing Made Easier
- Short residence times: High-speed purification of 5-30 bed volumes per minute
- High dynamic binding capacity: More than 10-fold higher binding capacities compared to conventional resins
- No size exclusion effects: Suitable for large proteins, viruses, and virus-like particles
- Aseptic processing: Available in gamma-irradiated formats to support closed processing
- Plug and play: Multiple device formats available, along with your choice of tubing and connectors
Sartobind Convec® D: Ensure High Recovery, Scalability, and Purity
- High recovery rates: Achieves more than 60%-80% recovery of infectious lentivirus particles
- High selectivity and purity: Reduces non-specific binding to maximize yield
- Short residence times: Increases throughput and productivity with rapid processing
- Linear scalability: Maintains consistent performance across scales
- Aseptic processing: Available in gamma-irradiated formats to support closed processing
- Plug and play: Multiple device formats available, along with tubing and connectors
Sartobind Convec® SC: Drive Efficiency for Vaccines and Virus-Like Particles
- High dynamic binding capacity: Enhances process efficiency for large biomolecules
- High selectivity and purity: Reduces non-specific binding to maximize yield
- Short residence times: Increases throughput and productivity with rapid processing
- Linear scalability: Maintains consistent performance across scales
- Versatility: Compatible with many molecule sizes and types
- Aseptic processing: Available in gamma-irradiated formats to support closed processing
- Plug and play: Multiple device formats, tubing, and connectors available
Supporting Products & Services
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Frequently Asked Questions
Yes. Our Sartobind® and Sartobind Convec® membrane chromatography portfolio is linearly scalable from small-scale R&D (e.g., Nano, 3 mL) to GMP-grade capsules up to 1,200 mL or more. Since convective flow dominates over diffusive transport, performance remains consistent across scales, reducing the need for re-optimization at larger volumes.
Sartobind® Q is also commonly used for flow-through polishing steps, such as removing host cell proteins (HCPs), DNA, endotoxins, and virus particles from monoclonal antibodies and recombinant proteins. Sartobind® Q gamma is also used for the Adenovirus and pDNA capture step. Its high flow rate, low pressure drop, and scalability make it suitable for both upstream clarification and downstream polishing in GMP manufacturing environments.
Sartobind Convec® D is designed for the chromatography capture step in the downstream process of lentivirus production.
Membranes use convective flow, resulting in short residence times and lower shear stress compared to resin columns. Also, elution under mild salt conditions (<500–750 mM NaCl) and reduced exposure to process-induced stressors help maintain infective particle integrity.
Our Sartobind Convec® D membranes allow DNA, proteins, and other host cell impurities to flow through, while selectively binding lentivirus particles. This enables a dual function: capture and partial purification in a single step. Sartobind Convec® D showed > 90% host cell protein removal.
Unlike traditional heparin-based resin columns, which have heparin from animal-based origin, Sartobind Convec® SC has a synthetic (chemical) based ligand. It features convection-driven flow, which minimizes diffusion limitations and enables faster processing of large biomolecules and viral particles, making it ideal for virus capture steps in vaccine manufacturing.
