Resolute® Flowdrive: Low Pressure Liquid Batch Chromatography Systems
Chromatography Systems for Clinical and Commercial Biomanufacturing
Resolute® batch chromatography systems provide a scalable platform for bioprocesses requiring low-pressure chromatography, including antibody drug conjugates (ADCs), blood plasma products, vaccines, recombinant proteins, and monoclonal antibodies (mAbs). Available in single-use and stainless-steel variants, the cGMP-ready systems support clinical phases 1, 2, and 3 through to commercial production.
Liquid Chromatography Systems Portfolio
These high-resolution systems ensure excellent product recovery during both capture and polishing, and support affinity, bind-elute, rapid cycling, and flow-through modes.
Request a quick quote from your local sales representative or learn more about engineered-to-order systems.
Parameter | 1/4 inch Flow Kits | 3/8 inch Flow Kits | 1/2 inch Flow Kits |
Volumetric flow | 8 to 150 L/h | 18 to 600 L/h | 36 to 900 L/h |
Column diameter | 6 to 25 cm | 10 to 60 cm | |
Tubing internal diameter (ID) | 1/4 in. | 3/8 in. | 1/2in. |
Pressure rating | 0 - 4 bar | ||
Single-use diaphragm pumps | 1-2 (dependent on configuration) | ||
Inlets | 6 (per pump) | ||
Outlets | 4 | ||
Pre-column sensor options | Conductivity, pH, flow meter, temperature | ||
Post-column sensor options | Conductivity, pH, UV, temperature | ||
Pressure sensors | 3 | ||
Resolute® Flowdrive MU systems provide a configurable range of systems across a variety of flow rates and sizes with stainless-steel flow paths. The options available cover the most popular functionalities that users demand from multi-use batch systems.
- Every system is capable of in-line dilution and gradient formation in a two-pump configuration or isocratic operation in a single-pump format
- Designed to process both columns and membrane devices
- Available in both CE and UL options, with other certifications available upon special order
- Configurable options for inlet and outlet numbers, instrumentation, bubble trap, and filter, among others
- Full customization service available, covering all chromatography needs, including in-line conditioning (ILC) with buffer preparation skids, medium-pressure (MPLC), explosion-proof design, and steam-in-place (SIP) capabilities
| S | M | L | XL | XXL | |
|---|---|---|---|---|---|
| Flowrate | 5-150 L/h | 20-500 L/h | 30-1,200 L/h | 60-2,500 L/h | 150-5,000 L/h |
| Pipe ID | 0.325" | 0.5" | 0.75" | 1" | 1.5" |
| Pressure | 4 bar | 6 bar | 6 bar | 5 bar | 4 bar |
Supporting Products & Services
Learn More About Liquid Chromatography Systems
Related Assets
A New Way to Perform mAb Capture: Scaling Rapid Cycling Membrane Chromatography From Bench to Commercial Manufacturing
PDF | 492.4 KB
Operating Instructions Resolute® BioSC Software for Resolute® Flowdrive Atex S, M, L, XL | Resolute® BioSC Pilot
PDF | 7.8 MB
Frequently Asked Questions
Please ask for a virtual demo from your local Sartorius representative.
Yes. Both pump systems are capable of linear gradient and in-line dilution out of the box. The gradients can be controlled by pump speed or closed-loop instrument feedback.
Yes. In-line conditioning (where buffers are formulated at the point of use) is possible on a custom basis. Contact your local representative to discuss your application with one of our subject matter experts.
We can offer solutions for hazardous areas | explosion-proof design, steam-in-place, medium pressure, or larger systems.