Process Development with Biostat STR® Generation 3 and Biobrain® Automation Platform

The Biostat STR® Generation 3 Single-Use Bioreactor System powered by the Biobrain® automation platform is designed for accelerated process development and seamless scaling to commercial manufacturing. 

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Biostat STR® Generation 3 is engineered for seamless scalability which allows you to scale up rapidly and reach IND stage quickly

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Realize Rapid Deployment and Seamless Scalability

Based on the architecture of the Biobrain® automation platform, the Biostat STR® system allows you the flexibility and power to quickly and easily make configuration upgrades and scale your process. 

  • Choose your ideal configuration of pumps, balances, sensors, and other equipment, then update as needed, often with a simple software change 
  • Enrich your process understanding and control with BioPAT® MFCS, a specialized SCADA software that captures, stores, and visualizes process data 
  • Predict conditions required to accurately scale your process using our BioPAT® scaling tool 
  • Gain an in-depth understanding and precise control of your process utilizing the extensive range of software and analytics in the BioPAT® toolbox 
  • Customize your process by leveraging our experienced engineering design and technical support teams to select from our broad range of robust technologies and analytical tools 

Maximize Quality, Consistency, and Productivity

Biostat STR® is engineered for highly efficient mixing and high oxygen transfer. In addition to the standard features, you can incorporate advanced features such as an integrated spectroscopy port, Repligen’s XCell™ ATF cell retention device, BioPAT® process control tools and software, and sophisticated analytics. Biostat STR® delivers: 

  • Superior cell viability and density
  • Higher product purity
  • Lower risk of batch loss or inconsistencies
  • Improved process understanding, control, and productivity
  • Systematic cost savings at all phases of production

BioPAT® Toolbox

Gain an in-depth understanding and precise control of your process. The sensors, software, and advanced analytics in the BioPAT® toolbox help ensure the purity, quality, safety, and batch-to-batch consistency of your product.

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Click on the + icons to view all the sensors available in the new Biostat STR®

Biostat STR® Generation 3 Configurations

Our process development solutions have been predesigned into three configurations with flexible options and easy upgrades. Select the configuration that best fits your current needs and you can conveniently adapt for any future requirements



Performance Plus

  Perfusion ready

Process Analytical Technologies (PAT) Toolbox

  BioPAT® Foam



  BioPAT® Trace



  BioPAT® Viamass



  BioPAT® Xgas



  BioPAT® Spectro



  Electrochemical pH sensor


  No. of external pumps




  Load cells

  Mass flow controller




  Flexsafe STR® bags

  Sartocheck® bag tester



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On-Demand Webinars:


Introducing the New Biostat STR® Generation 3 Powered by Biobrain®

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The Concept of Upstream Scaling: From Theory to Practice

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Virtual Presentation on Intensified Upstream Processing

Scalability and implementation of integrated PAT from process development to manufacturing

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Brochure: Biostat STR® Generation 3 and Biobrain® Automation Platform for Process Development

PDF | 392.3 KB

Poster: A Rapid, Low-risk Approach for Process Transfer of Biologics from Development to Manufacturing Scale

PDF | 1.2 MB

Article: A Rapid, Low-Risk Approach for Process Transfer of Biologics From Development to Manufacturing Scale

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