Rapid Cycling Chromatography in mAb Capture

Requirements for High Productivity

Rapid Cycling Chromatography (RCC) in bioprocessing offers extremely high productivity compared to traditional and multi-column chromatography. Implementing RCC requires the tuned interaction of:

  • A purpose-designed membrane
  • Suitable devices
  • A supporting skid technology

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The base matrix needs to provide high mass transfer combined with high permeability. The novel 'convecdiff' membrane enables high binding capacity with residence time of seconds. In order to ensure suitability for bioprocessing, providing adequate bed height in a scalable and proven device portfolio is required. An optimized skid must address the challenges of running many cycles in a short time – fast flow rates, rapid buffer changes, and data handling and analysis.

In addition to 15 to 20 times higher productivity, RCC allows process simplification, miniaturization and flexibility, as well as bioburden risk mitigation and bound capital reduction.

3 Requirements for Rapid Cycling Chromatography

1. 'Convecdiff' Membrane

  • High mass transfer
  • High permeability
  • Low fouling

2. Scalable Device Portfolio

  • Steep breakthrough curve
  • Sharp elution peak
  • Scalable from 3 mL to 100 L

3. Chromatography System

  • Optimized for membranes
  • Rapid Cycling technology
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New Membrane Chromatography System – MU RCC

MU RCC is a liquid chromatography system intended for small scale production and process development in the purification of mAbs, ADC, vaccines, viral vectors, and recombinant proteins. This system provides a tailored design and configuration for the implementation of Rapid Cycling Chromatography (RCC) to overcome the limitations of processes based on resins.

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