Rapid Cycling Using Chromatography Membranes and Monoliths
Intensification of a chromatography step can be taken as an opportunity to disrupt the status quo and redesign the way you do chromatography. Rapid Cycling Chromatography (RCC), with our membranes and monoliths, offers a simplified alternative to traditional batch chromatography. RCC with these convective media provides extremely high productivity compared to resins, while eliminating column handling and associated non-value-added activities such as column cleaning, packing and validation.
RCC with Sartobind® Rapid A allows >10x higher productivity than traditional capture using resins
RCC eliminates column handling, provides optimal media utilization per batch, thereby reducing costs & waste
No columns and one-batch-one-membrane approach eliminates operator error, contamination and bioburden risks
Learn More About RCC
Find the Right Intensified Batch Chromatography System
We offer the following two systems for implementing RCC along with a global team of Field Application Specialists that can help with installation, training and application support.
Resolute® Flowdrive SU | Resolute® RCC MU | |
|---|---|---|
Scale | Clinical | Commercial Scale | Process Development | Clinical Scale |
Process Type | RCC, batch | RCC |
Single-use or multi-use | Single-use | Multi-use |
Flow Rate Range | 18-900 L/hr | 5-150 L/hr |
3 Requirements for Rapid Cycling Chromatography
1. Convective Media
- High mass transfer
- High permeability
- Low fouling
2. Scalable Device Portfolio
- Steep breakthrough curve
- Sharp elution peak
- Scalable from 3 mL to 100 L
3. Chromatography System
- Fast flow rate
- Rapid buffer changes
- User friendly data handling
Our Portfolio
Resolute® RCC MU
Resolute® RCC MU is a multi-use liquid chromatography system intended for purification of mAbs, ADC, vaccines and recombinant proteins. This system provides a tailored design and configuration for the implementation of Rapid Cycling Chromatography (RCC) to overcome the limitations of processes based on resins.
Resolute® Flowdrive SU
Resolute® Flowdrive SU is a single-use liquid chromatography system that provides unparalleled flexibility for implementing Rapid Cycling Chromatography, traditional batch chromatography, as well as multi-product manufacturing.
