Transforming Biologics Discovery Through Innovation
Gain More Insights and Make Better Decisions Earlier
Biologic drugs have transformed modern medicine and their continued evolution gives greater promise for many patients with serious or untreatable conditions such as cancer, infectious, neurological, and autoimmune diseases.
The field of immunotherapy has witnessed a remarkable evolution from traditional antibodies to next-generation antibodies. These include antibody–drug conjugates (ADCs), bispecific antibodies, engineered antibodies, antibody fragments, and nanobodies, which have been engineered to enhance characteristics such as target cell killing potency and specificity.
Sartorius provides scientists with innovative, groundbreaking solutions and technologies to enable deeper insights and streamlined workflows that accelerate and improve the outcomes of preclinical trials, helping to enhance your productivity and reduce the time and cost of drug development.
Innovations to Advance Key Biologics Research
Featured Products for Biologics Discovery & Development
CellCelector Fully Automated Cell Imaging and Picking System
- High-throughput single plasma B-Cell and Hybridoma clone screening for antibody discovery
- Automated picking of Hybridoma and CHO clones
- High-throughput single cell cloning or single B-cell secretion assays in antibody discovery
- Compatible with single cell RNA analysis applications
Incucyte® Live-Cell Analysis System
- Remote image acquisition and analysis while cells remain safely within their tissue culture environment
- More biologically and physiologically relevant insights
- Protect against artificially induced artifacts with non-perturbing Incucyte® reagents
iQue® 3 High-Throughput Cytometry Platform
- High content, multi-factorial results for greater biological insight
- 1 µL sample volumes help conserve precious samples
- Acquisition and analysis software designed specifically for drug discovery
- Unparalleled speed allows library screening in days, not months
Octet® Label-Free Bio-Layer Interferometry (BLI) Detection Systems
- Parallel processing of up to 96 samples; non-destructive and in real-time
- Quantitation or binding kinetics measured directly in unpurified samples
- Ease of use with minimal maintenance, perfect for multi-user environments
Clarification, Concentration and Purification of Proteins
Successful screening of candidate molecules is followed by optimization of antibody purification conditions. The mAb purification process involves multiple steps, including cell culture clarification, antibody capture by affinity chromatography, polishing by ion exchange, concentration, and sterile filtration.
Sartorius offers an entire suite of products and solutions to streamline the mAb purification process.
RUO Growth Factors and Cytokines
Cytokines and growth factors are key immune system signaling molecules that regulate immune responses, inflammation, cell growth, and differentiation. Their research has advanced our understanding of immune-related diseases and led to the development of targeted therapies and vaccines.
Sartorius produces high-quality, recombinant cytokines and growth factors for research purposes, free from animal-derived components. These rigorously tested products ensure reliable results, consistent supply, and meet the highest purity and efficacy standards, with ISO9001-certified quality management.
Classical Cell Culture Media & Reagents for Research Labs
Sartorius ready-to-use media are designed to support the growth and maintenance of a variety of cells and cell lines while meeting the highest quality standards. Each lot is manufactured under a strictly controlled process according to a Product Master Record for lot-to-lot consistency.
Transfection Reagents
Our extensive range of ready-to-use transfection reagents are suitable for research involving most mammalian primary cells and cell lines. These best-in-class transfection products allow scientists to study the function of a protein of interest, its role in a signaling pathway, perform genome editing using plasmid-based or RNA-based proven methods, and to conduct cost-effective RNA interference to transfect guide RNA and express Cas9 protein in mammalian cells.
- Ready-to-use transfection reagents suitable for most mammalian primary cells and cell lines
- Specialized reagents for targeted gene expression, genome editing, and RNA interference studies
NexaGel® 3D Cell Culture Matrices
*NexaGel® hydrogel is a ready-to-use, versatile synthetic matrix system that closely replicates the human microenvironment, making it ideal for research involving a wide range of cell types. NexaGel® hydrogels feature optimized multi-functional ligands and concentration formulations, suitable for various applications, including 3D cell models, stem cell spheroids, and organoids.
- Ready-to-use synthetic hydrogels that are animal-component free
- Can be used in a range of applications involving 3D cell models, stem cell spheroids, and organoids
*NexaGel® is a registered trademark of Sartorius Bioanalytical Instruments, Inc. For details on the registrations please refer to our website https://www.sartorius.com/en/patents-and-trademarks
Microtissue Technologies, Primary Cells, Cultureware, and Testing Services
Explore ready-to-use 3D human-derived microtissue models, human primary cells, high-quality glass bottom cell culture dishes and plates for superior imaging, as well as toxicology testing services for industries such as cosmetics, pharmaceutical, chemical, and other regulated industries.
Frequently Asked Questions
A comprehensive list of various studies and publications in mAb research and development can be found on the following pages:
Future directions include the development of multi-specific antibodies, antibody-drug conjugates, the use of artificial intelligence as well as multi and single-cell omics to predict and design novel antibodies. These advancements aim to create more effective and personalized treatments for a wide range of diseases.
Antibodies can be used to target specific proteins involved in neurological conditions, making antibody discovery highly relevant for developing treatments for neurodegenerative diseases like Alzheimer's and Parkinson's. By binding to and neutralizing pathological proteins such as amyloid-beta in Alzheimer's or alpha-synuclein in Parkinson's, these antibodies have the potential to halt or slow the progression of these debilitating neuro disorders, offering new hope for therapeutic interventions. Monoclonal antibody therapies delivered as injectables often face challenges in reaching the central nervous system due to the Blood-Brain Barrier (BBB). To circumvent this issue, various strategies are under development, including engineering antibodies to cross the BBB and developing smaller biomolecules or delivery systems, such as antibody-drug conjugates (ADCs) and nanoparticles.
The Incucyte® Live-Cell Analysis System revolutionizes oncology research by enabling continuous, real-time analysis of live cells. This allows for the observation of dynamic biological processes without disturbing the cells, leading to more accurate and comprehensive data.
Key applications:
- Studying selective proliferative advantage
- Investigating invasion and metastasis
- Exploring immune modulation
- Analyzing metabolic rewiring
CellCelector can advance the development of antibodies and biologics by enabling precise and efficient isolation of high-producing cell lines, facilitating the generation of monoclonal antibodies, and accelerating the screening and selection process for therapeutic candidates.
Key applications:
- Isolation of single antibody-producing cells
- Clonal selection and expansion
- Screening and picking of high-producing cell lines
- Retrieval of rare cell populations
- Generation of monoclonal antibodies
- Cell line development for biologics production
The iQue® HTS platform is essential for evaluating all characteristics of biologics using low-volume, rapid, and high-throughput methods. Its capability to capture multiparametric data enables the assessment of live cell binding affinities across various cell types within a single well, while also facilitating the quantification of biological functions such as ADCC (Antibody-Dependent Cell-Mediated Cytotoxicity) or ADCP (Antibody-Dependent Cellular Phagocytosis).
Octet® Biolayer Interferometry (BLI) advances biologics development by providing rapid and accurate measurements of binding kinetics and affinities, product titer, and contaminants detection throughout your workflow. It enables high-throughput screening of potential drug candidates and facilitates the characterization of complex biomolecular interactions, which are critical for developing effective biologics.
Compared to other biomolecular binding analysis methods such as Enzyme-Linked Immunosorbent Assay (ELISA), using Biolayer Interferometry (BLI) offers several key advantages:
- Label-free detection, which preserves the native state of biomolecules
- Real-time analysis, allowing for the observation of binding events as they occur
- High sensitivity and specificity
- Ability to analyze crude samples without extensive purification
