TFF Systems
Process Solutions for Ultrafiltration and Diafiltration
Sartorius offers flexible tangential flow filtration systems for process development and clinical trials in laboratory environments as well as for commercial production batches. Whether you are looking for a cost-efficient multi-use solution or a functionally closed solution with single-use flow paths for aseptic processing, our TFF portfolio offers the right option to meet your individual requirements.
Find the Right TFF System
Screening (5 mL – 500 mL) 10 mg – 5 g
With the Ambr® Crossflow, Sartorius offers a high throughput solution for parallel screening. It provides access to molecule behavior at the early development stages.
No of parallel trials | 4, 8, 12 or 16 |
Min recirculation volume | 5 ml |
Membrane area | 10 cm2 |
Development (20 mL – 5 L) 0.5 g – 50g
The Sartoflow® Smart is the ideal crossflow system for process development. Receive the highest product yields with the low shear membrane pump.
Membrane area | 50 cm2 – 0.14 m2 |
Minimum working volume | <20 mL |
Options available | Yes (e.g., pH, conductivity, temperature sensors) |
Process Development / Pre-Clinical 2 – 50 L (20 g 500 g)
Sartorius offers flexible TFF solutions to meet your individual requirements. Find the right technology to speed up your process development and for your small-scale production.
| Membrane area | 0.1 - 0.4 m2 | 0.1 - 2.1 m2 |
Minimum working volume | <200 mL | ~170 mL |
Process mode | Single-use | Multi-use |
Pilot & clinical 20 – 500 L (200 g – 5 Kg)
Qualified and compliant pilot or clinical process scale systems to enable rapid and flexible cGMP scale-up of bioprocesses.
Multi-functional | No | Yes |
Recirculation holdup volume | Very low | Low |
Automation & sensor level | Fully process automated | Fully process automated |
Colorimetric installation guidance | HMI & consumables | No |
| Fully self-contained SU fluid contact | No (switch to SC Sartocon) | Yes (self-contained Sartocon) |
Commercial Production 100-2000L (500 g – 20 Kg)
Robust commercial manufacturing scale systems to cover larger throughputs of cGMP single-use biological purification.
Multi-functional | No | Yes |
Recirculation holdup volume | Very low | Low |
Automation & sensor level | Fully process automated | Fully process automated |
Colorimetric installation guidance | HMI & consumables | No |
| Fully self-contained SU fluid contact | No (switch to SC Sartocon) | Yes (self-contained Sartocon) |