TFF Systems

Process Solutions for Ultrafiltration and Diafiltration

Sartorius offers flexible tangential flow filtration systems for process development and clinical trials in laboratory environments as well as for commercial production batches. Whether you are looking for a cost-efficient multi-use solution or a functionally closed solution with single-use flow paths for aseptic processing, our TFF portfolio offers the right option to meet your individual requirements.


Find the Right TFF System

Screening (5 mL – 500 mL) 10 mg – 5 g

With the Ambr® crossflow, Sartorius offers a high throughput solution for parallel screening. It provides access to molecule behavior at the early development stages.

Attributes

Ambr® crossflow 

No of parallel trials 

4, 8, 12 or 16

Min recirculation volume

5 ml

Membrane area

10 cm2 

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Development (20 mL – 5 L) 0.5 g – 50g

The SARTOFLOW® Smart is the ideal crossflow system for process development. Receive the highest product yields with the low shear membrane pump.

Attributes

SARTOFLOW® Smart

Membrane area 50 cm2 – 0.14 m2 
Minimum working volume <20 mL 
Options available Yes (e.g., pH, conductivity, temperature sensors) 

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Process Development / Pre-Clinical 2 – 50 L (20 g 500 g) ​

Sartorius offers flexible TFF solutions to meet your individual requirements. Find the right technology to speed up your process development and for your small-scale production. 

Attributes 

CM 150 System

SARTOFLOW® Advanced

Membrane area 

0.1 - 0.4 m2

0.1 - 2.1 m2

Minimum working volume

<200 mL

~170 mL

Process mode

single use

Multi use

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See Product Details


Pilot & clinical 20 – 500 L (200 g – 5 Kg​)

Qualified and compliant pilot or clinical process scale systems to enable rapid and flexible cGMP scale-up of bioprocesses. 

Attributes

CS 1000 System

Flexact Modular® C4F

Multi-functional

No 

Ýes

Recirculation holdup volume

Very low 

low 

Automation & sensor level

Fully process automated

Fully process automated

Colorimetric installation guidance

HMI & consumables

No

Fully self-contained SU fluid contact 

No (switch to SC Sartocon)

Yes (self-contained Sartocon)

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Commercial Production 100-2000L (500 g – 20 Kg)

Robust commercial manufacturing scale systems to cover larger throughputs of cGMP single-use biological purification.

Attributes

CS 4500 System

Flexact Modular® C4F

Multi-functional

No 

Yes

Recirculation holdup volume

Very low 

low 

Automation & sensor level

Fully process automated

Fully process automated

Colorimetric installation guidance

HMI & consumables

No

Fully self-contained SU fluid contact 

No (switch to SC Sartocon)

Yes (self-contained Sartocon)

See Product Details

See Product Details