Sartoflow® Smart Small-Scale Benchtop TFF System

Smart and Easy — The TFF System for Process Development

The Sartoflow® Smart is a modular and flexible small-scale TFF benchtop system optimized for ultrafiltration and diafiltration applications used in many downstream processes, such as purification of vaccines, monoclonal antibodies and recombinant proteins. The system is well-suited to laboratory environments for process development and clinical trials as well as small batch cGMP production.

icon ergonomic hand
Excellent flexibility

Ideal for membrane surface areas from 50 cm2 to 0.14 m2 with optional customization features

Intuitive and user-friendly

Easy-to-use out of the box with predefined sequences

High product yields

Low shear 4-piston membrane pump and very compact 20 mL recirculation volume for maximum yield

Excellent Flexibility

The Sartoflow® Smart is a modular and flexible small-scale system with many customization options:

  • External diafiltration pump
  • Sartocon® Slice 50 cassette holder
  • Sensors for pH, conductivity and temperature
  • External permeate balance up to 64 kg (vs 7 kg standard)
  • Recirculation and/or permeate holder for Flexboy® bags
  • IQ/OQ execution package 
  • Basic qualification test documentation 
  • cGMP documentation

Intuitive Operation With Predefined Production Sequences

With an intuitive, user-friendly interface, operators can use predefined parameters to automatically run customized sequences for concentration, diafiltration (UF | DF), rinsing, filling, draining and flushing steps.

Pivotal for Process Scalability

The Sartoflow® Smart TFF system is the ideal tool for developers establishing and refining process parameters in scale-up and scale-down studies.

  • Low minimum sample volume
  • Low minimum recirculation volume
  • Easy data access
  • Full transferability of process parameters to large-scale systems

Sartoflow® Smart Overview

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Learn More About Sartoflow® Smart

General Specification 



~35 kg (77 lbs.)


602 × 440 × 610 mm

System Specification 

Membrane Area 

50 cm² , 200, 400 cm², 0.14 m²

Recirculation Vessel VolumePSU vessel with stirrer: 1 L 
Flexboy® single-use bags: 150 - 1,000 L

Flow Rate

1–100 L/h @ 3 bar (43.5 psi)

Minimum Recirculation Volume

< 20 mL

Automation Level 

Semi automated

Process Mode (Multi-Use/ Single-Use) 


cGMP Available  


Max Pressure 

3 bar (43.5 psi)

Temperature Control 

No, monitoring only

Wetware Specification 

Tube ID





Pressure (in line: feed, permeate, retentate) Conductivity, pH, temperature ( in PSU vessel)

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Application Note

Downstream Processing of a Mid-Scale LentiviralVector Batch for the Generation of CAR-T Cells

PDF | 413.6 KB

Sartoflow® Smart - Smart and Easy TFF System For Process Development

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Sartocon® Slice 50 Small Scale Process Development Disposable Ultrafilters for Biopharmaceutical Applications

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