SARTOFLOW® Smart - The Crossflow System for Process Development
Smart and Easy - Small Scale Benchtop System
The SARTOFLOW® Smart is a modular and flexible small scale benchtop crossflow system optimized for ultrafiltration and diafiltration applications used in many downstream processes, such as purification of vaccines, monoclonal antibodies and recombinant proteins. The system is suitable for use in laboratory environments for process development and clinical trials as well as for cGMP environments.
Excellent Flexibility
Ideal for membrane surface areas
from 50 cm2 to as much as 0.14 m2
Intuitive and User-Friendly
One operating design and predefined sequences for all SARTOFLOW® systems
The Highest Product Yields
Low shear 4-piston membrane pump
One System – Highest Flexibility
The SARTOFLOW® Smart can be configured to accept either Sartocon® Slice 200 or Sartocon® Slice ECO UF cassettes. An optional holding device for 50 cm2 filtration modules e.g. Sartocon® Slice 50 is available.
The recirculation tank utilizes a load cell for level control and can be replaced by a recirculation bag stand with Flexboy® bags. All control functions are fully operable whether you run the system with a polysulfone (PSU) tank or a single-use bag.
SARTOFLOW® Smart Overview
Intuitive Operation – Predefined Production Sequences
You can use predefined parameters to automatically run customized sequences for concentration, diafiltration (UF | DF), rinsing, filling, draining, flushing steps and tare functions. This allows intuitive and user-friendly operation.
DCU-4 touch screen
Process Sequences
The following production sequences are provided by the system
Con-Di-Con | Used to concentrate the product to a predefined level and to diafilter the product subsequently - followed by concentration to a final level. |
Concentration | Used to concentrate the product to a predefined final level. |
Diafi-Conc | Diafiltration of the product. At the end of this phase, the product is concentrated to a predefined volume. |
Flushing | Used to rinse the system by flushing the system with WFI, acidic or alkaline solutions. |
| Drain | harv | Used to drain or harvest the product from the system. |
| Filling | Used to fill the tank or bag with product. |
| Weight | Automatically zeros the load cell. |
Pressure | Automatically zeros all pressure sensors. |
Just select and start the phases on the control panel, and the DCU-4 will then execute the steps automatically. Interactions or process end will be indicated by text messages.
Optional software
- MFCS/Win Standard software package
- Recipe Control (S88) software module
- 21 CFR part 11 software module
- BioPAT® MFCS | win OPC
Sartocon® Slice 50
The ready-to-use 50 cm² crossflow device is the optimal choice for process development of biopharmaceutical solutions with small volumes. Its encapsulated design allows linear scale-up combined with identical material of construction. This eases the data transfer of process development results into the next level.
Sartocon® Slice 50 can easily be interfaced with the SARTOFLOW® Smart system.