Sartoflow® Advanced - The Modular Benchtop TFF System

Full Flexibility Meets Outstanding Performance

The Sartoflow® Advanced is a modular benchtop tangential flow filtration (TFF) system optimized for ultrafiltration and diafiltration applications used in many downstream processes, such as purification of vaccines, monoclonal antibodies and recombinant proteins. The system is suitable for flexible use in laboratory environments for process development and clinical trials as well as small batch cGMP production.

icon ergonomic hand
Flexible solution for UF | DF
  • Membrane surface areas from 0.1 m² to 2.1 m²
  • Stainless steel recirculation vessel or single-use bags

Intuitive and user-friendly

Easy-to-use out of the box with predefined sequences

High product yields

4-piston membrane pump for low shear

Highly automated

Two pumps for feed and buffer addition, as well as full TMP control

Match the System to Your Needs

The Sartoflow® Advanced is a modular benchtop TFF (crossflow) system with many options:

  • Ideal for both process development and small-scale production
  • Can accept either Sartocon® Slice or full-sized Sartocon® cassettes for a wide range of membrane surface areas
  • Stainless steel recirculation tank or single-use bags
  • Touch screen control interface
  • Full compatibility to BioPAT® MFCS software

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Intuitive, User-Friendly Controls

  • All control and alarm functions accessed via the 12" touch screen
  • Operators have immediate process control
  • Option to use predefined parameters to automatically run customized sequences for concentration, ultrafiltration/diafiltration (UF | DF), rinsing, filling, draining and flushing steps
  • Feed pressure and level controllers are standard
  • BioPAT® MFCS software is standard

Sartoflow® Advanced Overview

Related Products

Sartorius TFF Cassettes provide high-performance separation in various upstream and downstream bioprocessing unit operations and are available in a range of molecular weight cut-offs, from lab scale to process scale, in single-use and re-usable formats.

Hydrosart® Ultrafiltration Cassettes

Hydrosart® high-performance membrane is a stable cellulose-based membrane designed for biopharmaceutical process applications.

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Polyethersulfone Ultrafilter Cassettes

The polyethersulfone (PES) membrane is well-established in the biotechnological and pharmaceutical industries.

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Learn More About Sartoflow® Advanced

General Specification 



~120 kg (~265 lbs.)


1,100 mm x 800mm x 680 mm

System Specification 

Membrane Area 

0.1–0.5 m2 (optional 0.7–2.1 m2)

Vessel Volume 

10 L tank | 5, 10, 20 L bag

Flow Rate

700 L/h @ 4 bar (60 psi)

Volume in Feed and Retentate Lines

~ 200 mL 

Automation Level 

Fully automated

Process Mode (Multi-Use/ Single-Use) 


cGMP Available  


Max Pressure 

4 bar | 60 psi

Temperature Control 

Double walled tank available

Wetware Specification 

Tube ID 





  • Pressure (feed, permeate, retentate)
  • Flow (permeate, optional retentate)
  • Conductivity optional (retentate, permeate)
  • pH
  • Temperature

Related Assets


Sartoflow® Advanced - Full Flexibility and Outstanding Crossflow Filtration Performance Combined

PDF | 852.6 KB

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