Sartoflow® 1000 Pilot-Scale Single-Use Tangential Flow Filtration System

Efficient and Scalable Single-Use TFF System With Automated Processes

The Sartoflow® 1000 single-use tangential flow filtration (SUTFF) system offers all of the controls and instrumentation for running fully automated ultrafiltration and diafiltration (UF|DF) processes for batch volumes of 20 to 200 L (200 g to 2.5 kg). The system is compact, has low hold-up volume and has the capacity to run cassette surface areas from 0.6 to 2.8 m² and  hollow fiber modules from 0.13 to 5 m² filtration area (usable filter area is depending on filter type and process parameters).

icon ergonomic hand
Efficiency for pilot-scale manufacturing

Designed for efficiency in SUTFF applications, the system accommodates batches from 20 L up to 200 L

Intuitive and user-friendly

User-friendly process step editor simplifies automation

Fast turnaround times

Single-use flow kit supports rapid changeout and cleanability, maximizing batch turnaround

Automated SUTFF Processing

The Sartoflow® 1000 system facilitates automated processing of monoclonal antibodies, recombinant proteins and vaccines in batch volumes from 20 to 200 L. 
A user-friendly smart system design simplifies automation of TFF process sequences with complete single-use flow kits incorporating all critical sensor and instrumentation technologies.

Simple, Intuitive Control Over Automation

The Sartoflow® 1000 system incorporates a process step editor with a simple and user-friendly interface for automating operations.

  • Select transition points to advance process steps based on one or more parameters, such as conductivity, retentate volume, permeate volume and bag weight
  • Use loop and jump functions to create selective step repetitions and enhance flexibility
  • Generate batch reports for each step

Reduce Downtime Between Batches

Sartoflow® 1000 Flow kits allow for quick exchange between batches, minimizing cleaning or cleaning validation.

  • Manufactured in a controlled environment (ISO 7 cleanroom, in operation according to ISO 14644) under an ISO 9001-certified quality system
  • Components are tested for biocompatibility and USP<88> certified 
  • Components are EMA410/01 compliant and meet Rev3  TSE | BSE requirements
  • Supplied double-bagged and irradiated with a minimum dose of 25 kGy

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Learn More

Learn More About Sartoflow® 1000

System Overview


350 kg

System Dimensions

EMEA | Asia:
1,920 × 1,000 × 1,718 mm (nominal)

2,050 × 1,200 × 1,750 mm (nominal)


Conform to CFR21 Part 11

System Specification

Membrane Area*

0.6 m2 – 2.8 m2 (flat sheet)

0.13 m2 - 5 m2 (hollow fiber)

Vessel Volume

10 L, 20 L or 100 L

Flow Rate / Pump Capacity - Recirculation 

Flow range of 20-1,000 L/h

Flow Rate / Pump Capacity - Media Addition Pumps

6-600 L/h with 12.7 mm element

Minimum Recirculation Volume

1.2 L (with 20 L retentate bag)

Automation Level

Process Step Editor

Process Mode (Multi-Use / Single-Use)


Max Pressure

4 bar | 58 psi

Wettware Specification

Tube ID

½" (1.27 cm) feed/retentate

Sensor Options

Pressure, flow, conductivity, pH, temperature & UV

*usable filter area is depending on filter type and process parameters

Related Asstes


Sartoflow® 1000: Single-use Tangential Flow Filtration System

PDF | 923.8 KB
Technical Note

Summary of Extractables from Sartoflow® Single-Use Tangential Flow Filtration (SUTFF) Flow Kits

PDF | 306.7 KB

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