Real-Time Process Intelligence to Raise Your Manufacturing IQ

When your manufacturing process drifts from its optimal operating conditions, you need to know about it—before it has a chance to affect product quality or yield. SIMCA®-online monitors your production processes in real-time for a continuous snapshot of operations. Our proprietary multivariate prediction technology gives you early warning of process anomalies that will affect the end product. With this real-time process intelligence, your production team can proactively drive the best possible outcomes. And that means you can ensure consistent product quality, maximize productivity, and prevent costly re-work or scrapping.

Are you confident your process is on track to meet quality targets? Do you wish you could cut down on complexity and decipher process control data more quickly and easily?  What if you could easily visualize and interpret the behavior of all your processes at a glance, with just a few clicks? Find out how SIMCA®-online uses multivariate data analysis (MVDA) modeling to eliminate the complexity of traditional process monitoring so you get clear actionable insights—exactly when you need them, no matter where you are. 

SIMCA®-online is the First Choice for Real-Time Batch Process Monitoring.

  • Increased process visibility from end-to-end with Control Advisor dashboard
  • Highly accurate end point prediction and forecasting
  • Real-time analysis of vital parameters and their correlation patterns
  • Early fault detection and warning of process deviations
  • Interactive visuals for instant insights and guidance on corrective and preventative actions
  • Batch to batch comparison at a glance
  • Process intelligence to maximize productivity and improve product quality
Remote predictive monitoring

SIMCA®-online provides real-time analysis of vital parameters and their correlation patterns. Processes can be monitored remotely, in real-time, from connected servers by using windows or web clients.

Fault detection and deviation alerts

Alarms can be set to enable early detection of possible process upsets. Alerts with email notifications makes sure the information quickly reaches all stakeholders.


Multivariate charts summarize your process. For deviating observations use drill-down functionality to identify root causes for analysis.

Predicting final quality attributes

Accurate prediction, forecasting, and validation of the final quality attributes allow for quality control to take place ahead of production completion.

Real-time supervisory control

SIMCA®-online uses an “ideal process” model to anticipate the effect of changes and recommend immediate adjustments to change your process parameters for optimal results.

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Benefit From the Unique Power of SIMCA®-online 

Save Time and Money in Production

SIMCA®-online takes advantage of the latest advanced analytics to detect when your process is deviating from the ideal and provide insight into the underlying causes.  This means less time and resources spent on root cause analysis, and added profit from batches that would otherwise be scrapped or require costly re-work. 

Proactively Improve Product Quality

With accurate prediction, forecasting and validation of the final quality attributes, quality control can take place ahead of production finish.  In addition, SIMCA®-online Control Advisor provides guidance on how to change the process to reach a better end state, so operators can take proactive steps to improve product quality.

Minimize Risk and Ensure Compliance

SIMCA®-online makes it easy to implement best practice for continued process verification, helping you safeguard vital processes and ensure compliance with quality standards, regulations and industry guidance for good manufacturing practice such as 21 CFR part 11.

News in Latest Release of SIMCA®-Online

New batch context node type, batch aggregation node, adds flexibility and enables monitoring of entire process lines. Freedom to use any analytics within Python realm by managing Python packages on the server, for use of preprocessing scripts added in SIMCA®. Data source connections, SimApis, can be updated at any time without interrupting users or live monitoring of the process. Performance optimizations allow for more configurations to run at the same time and faster plot updates. Improvements to Active Directory integration for a reduced need for manual user management, while keeping full control of user permissions.

Learn More About Batch Process Modeling Using MVDA

Discover the secrets of overviewing batch data tables and learn how to build robust predictive models that turn data into decisions. Using the latest multivariate techniques, participants will learn how to interpret complex data quickly and confidently.

The course is composed of lectures, demonstrations and computer exercises in SIMCA® software, based on real-life datasets. 

Upcoming Courses


Webinar: Real-Time Process Monitoring Through SIMCA®-online 17

Learn about the basics of real-time process monitoring and understand the power of SIMCA®-online for monitoring cell culture processes.

Watch Now


Applications Notes

Application Note

Applications of Multivariate Data Analysis in Biotech Processing

PDF | 1.6 MB
Application Note

PAT IN-DEPTH FOCUS - Process Analytics Experiences in Biopharmaceutical Manufacturing

PDF | 879.3 KB
Application Note

SIMCA®-online - Control Advisor

PDF | 426.5 KB
Application Note

PAT IN-DEPTH FOCUS - Correlation Between Powder Rheology Data and Processability in Solid Dosage Form Manufacturing

PDF | 487.9 KB
Application Note


PDF | 718.9 KB
Application Note

A Practical Approach for Exploration and Modeling of the Design Space of a Bacterial Vaccine Cultivation Process

PDF | 646.9 KB
Application Note

SIMCA®-online Use in Novartis

PDF | 4.5 MB

User Guides

User Guide

Web Client Installation Guide

PDF | 228.9 KB
User Guide

Read Me and Installation Guide

PDF | 205.3 KB
User Guide

SIMCA®-online 17 Help

ZIP | 10.2 MB
User Guide

Implementation Guide - SIMCA®-online

PDF | 313.7 KB
User Guide

Technical Guide - SIMCA®-online

PDF | 773.2 KB
User Guide

Quick Guide to Using Python Preprocessing Scripts in SIMCA®-online

PDF | 345.2 KB



SIMCA®-online - Ensuring manufacturing success

PDF | 943.3 KB
User Guide

News SIMCA®-online 17

PDF | 2.0 MB

News - SIMCA®-online 16.1

PDF | 1.7 MB

SIMCA®-online - What is control?

PDF | 372.6 KB


Tutorial - Control Advisor in SIMCA®-online

PDF | 959.0 KB

Control Advisor Models for SIMCA®-online - ZIP Folder

ZIP | 901.0 KB

Validation Report 

Validation Report SIMCA®-online 17.0.3

PDF | 109.3 KB

Validation Package SIMCA-online 17.0.3

ZIP | 111.0 MB

Validation Report SIMCA®-online Web Client 17.1

PDF | 90.8 KB

SIMCA®-online Web Client 17.1 Validation Package

ZIP | 24.9 MB

Validation Report SIMCA®-online 17.0.2

PDF | 89.1 KB

SIMCA®-online 17.0.2 Validation Package

ZIP | 66.5 MB

Validation Report SIMCA®-online 17.0.1

PDF | 150.5 KB

SIMCA®-online 17.0.1 Validation Package

ZIP | 42.0 MB

SIMCA®-online 17 Validation Report

PDF | 92.3 KB

SIMCA®-online 17 Validation Package

ZIP | 65.5 MB

Validation Report SIMCA-online 16.1.2 

PDF | 79.1 KB

SIMCA-online 16.1.2 Validation Package ZIP Folder

ZIP | 42.8 MB

SIMCA-online 16.1.1 Validation Plan and Report Numerical

PDF | 84.8 KB

SIMCA-online 16.1.1 Validation Package Numerical

ZIP | 21.9 MB

Validation Report SIMCA®-online 16

PDF | 70.6 KB

Validation Package SIMCA®-online 16 - ZIP Folder

ZIP | 134.0 MB

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