Crossflow Filtration

Crossflow Filtration

Consistent Product Recovery No Matter What

Get the maximum product yield using our unique Hydrosart® membrane technology. Benefit from a chemically resistant cellulose membrane. It ensures the highest product recovery even under harsh process conditions.

Save up to 3 hours from your UF|DF processing time using our unique cassettes and advanced crossflow system engineering.

Crossflow Cassettes and Systems for Highest Product Yields

Hydrosart® Cassettes for All Applications

The Most Resistant

Spend less time cleaning, sanitizing, steaming, and sterilizing. Our Hydrosart® cassettes use a unique membrane that has the highest chemical resistance, temperature stability and gamma compatibility. The Hydrosart® UF | DF cassette is the perfect fit for mAb, blood & plasma, vaccines and ADC processes.

Hydrosart® Microfilter

Hydrosart® Ultrafilter

Scalable Results with SARTOFLOW® Systems

Rapid Process Development

Operators using our configurable SARTOFLOW® crossflow systems benefit from a modular platform. Use the same automation, user interface, data acquisition and process analysis tools from process development to commercial manufacturing. Mitigate the risk of operator error and significantly reduce your development time in both single-use or multi-use processes.

SARTOFLOW® Crossflow Systems

Find Out Why Hydrosart® Crossflow Membranes are so Productive

Crossflow Filtration (also known as Tangential Flow Filtration, or TFF) is a filtration method used under dynamic flow conditions. Product feed flows tangentially along the surface of the membrane where the product molecule is retained, while buffer and contaminants pass through the membrane. Sartorius Crossflow Ultrafilters contain Hydrosart TFF Membranes of various molecular weight cut-offs to manage volume reduction and buffer exchange in antibody, vaccine, and blood & plasma processes. Hydrosart is the preferred and best performing TFF membrane for biopharmaceutical manufacturing.

Speed Up with Single-Use Crossflow Solutions

Single-use crossflow solutions are the key technology in fast and reliable downstream processing of biopharmaceutical products. Using a pre-sanitized, sterile single-use crossflow device enables the reduction of process steps, labor costs and buffer or WFI usage significantly.

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ambr® crossflow

The High Throughput Solution for Parallel Screening

ambr® crossflow provides at early development stages access to molecule behavior related to viscosity, buffer composition, shear stress and performance in membrane processes. It enables a lot of important additional decision criteria for the final candidate selection and speeds up this process significantly.

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Smart and Easy – The Crossflow System for Process Development

The ideal benchtop crossflow system for your process development and for small batch production in cGMP environments. Receive highest product yields with the low shear membrane pump.

SARTOFLOW® Smart offers excellent flexibility. It is ideal for membrane surface areas from 50 cm² to as much as 0.14 m². Try the new Sartocon® Slice 50 ready to use 50 cm² crossflow device which can easily be interfaced with the SARTOFLOW® Smart system. It is ideally suited for membrane screening, available in a wide variety of MWCO’s and membrane polymers.


Sartocon® Slice 50

Everything for Your Setup

Choose the Right Crossflow Cassettes

Every crossflow step in your biopharmaceutical process requires constant quality, batch-to-batch consistency and high performance filtration. With our crossflow cassettes we ensure maximum product yield in all required steps. Our wide product portfolio offers solutions for single-use or multiple-use and guarantees a linear scale-up.

Hydrosart® Microfilter Cassettes
Hydrosart® Ultrafilter Cassettes
Polyethersulfone (PES) Microfilter Cassettes
Polyethersulfone (PES) Ultrafilter Cassettes
Sartocon® Single-Use Assemblies

Holders and Accessories

The family of Sartorius crossflow filter holders features the latest advances in crossflow design for full flexibility. This unique design within the Sartocon® family provides you with predictable performance from process volumes down to scaling studies or in daily lab work.

Crossflow Filter Holder

CIP Flush Cassettes

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You Can Count on Our Support

Trust our comprehensive range of services for your bioprocess: We gladly assist you with tasks like system installation, process optimization and...

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